Infancy predictors of functional somatic symptoms in pre- and late adolescence: a longitudinal cohort study

Lina Münker; Martin Køster Rimvall; Lisbeth Frostholm; Eva Ørnbøl; Kaare Bro Wellnitz; Pia Jeppesen; Judith Gerarda Maria Rosmalen; Charlotte Ulrikka Rask

doi:10.1007/s00431-024-05850-7

Infancy predictors of functional somatic symptoms in pre- and late adolescence: a longitudinal cohort study

Lina Münker^*, Martin Køster Rimvall, Lisbeth Frostholm, Eva Ørnbøl, Kaare Bro Wellnitz, Pia Jeppesen, Judith Gerarda Maria Rosmalen, Charlotte Ulrikka Rask

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Physiological regulatory problems in infancy (i.e., problems with sleeping, feeding, and tactile reactivity) have been associated with impairing functional somatic symptoms (FSS) at ages 5–7. We aimed to extend this finding by examining not only the association of physiological regulatory problems but also other infancy factors (i.e., emotion dysregulation and contact problems) with FSS in pre- and late adolescence. Standardized behavioral assessments and self-report questionnaire data from assessment waves at 0–1, 11–12, and 16–17 years of the population-based Copenhagen Child Cohort (CCC2000) were linked with Danish register data on maternal postpartum psychiatric illness and family adversity as covariates. Multiple linear regression analyses were performed to examine the association between infancy factors and FSS in pre- and late adolescence. Only infancy physiological regulatory problems significantly predicted preadolescent FSS (b = 0.38, 95% CI [0.14, 0.62]), also when accounting for maternal postpartum psychiatric illness and family adversity. The association was attenuated for late adolescent FSS. Conclusion: Infancy physiological regulatory problems may represent early signs of a dysregulated stress system and were found to significantly predict FSS in pre- but not late adolescence. Implications for early FSS prevention could include testing interventions promoting infants’ regulation of sleep, feeding, and tactile reactivity. (Table presented.)

Original language	English
Article number	57
Book series	European Journal of Pediatrics
Volume	184
Issue	1
ISSN	0340-6199
DOIs	https://doi.org/10.1007/s00431-024-05850-7
Publication status	Published - Dec 2024

Keywords

Adolescent
Family adversity
Functional somatic symptoms
Infancy contact problems
Infancy emotion dysregulation
Infancy physiological regulatory problems
Maternal postpartum psychiatric illness
Predictors

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10.1007/s00431-024-05850-7Licence: CC BY

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title = "Infancy predictors of functional somatic symptoms in pre- and late adolescence: a longitudinal cohort study",

abstract = "Physiological regulatory problems in infancy (i.e., problems with sleeping, feeding, and tactile reactivity) have been associated with impairing functional somatic symptoms (FSS) at ages 5–7. We aimed to extend this finding by examining not only the association of physiological regulatory problems but also other infancy factors (i.e., emotion dysregulation and contact problems) with FSS in pre- and late adolescence. Standardized behavioral assessments and self-report questionnaire data from assessment waves at 0–1, 11–12, and 16–17 years of the population-based Copenhagen Child Cohort (CCC2000) were linked with Danish register data on maternal postpartum psychiatric illness and family adversity as covariates. Multiple linear regression analyses were performed to examine the association between infancy factors and FSS in pre- and late adolescence. Only infancy physiological regulatory problems significantly predicted preadolescent FSS (b = 0.38, 95% CI [0.14, 0.62]), also when accounting for maternal postpartum psychiatric illness and family adversity. The association was attenuated for late adolescent FSS. Conclusion: Infancy physiological regulatory problems may represent early signs of a dysregulated stress system and were found to significantly predict FSS in pre- but not late adolescence. Implications for early FSS prevention could include testing interventions promoting infants{\textquoteright} regulation of sleep, feeding, and tactile reactivity. (Table presented.)",

keywords = "Adolescent, Family adversity, Functional somatic symptoms, Infancy contact problems, Infancy emotion dysregulation, Infancy physiological regulatory problems, Maternal postpartum psychiatric illness, Predictors",

author = "Lina M{\"u}nker and Rimvall, {Martin K{\o}ster} and Lisbeth Frostholm and Eva {\O}rnb{\o}l and Wellnitz, {Kaare Bro} and Pia Jeppesen and Rosmalen, {Judith Gerarda Maria} and Rask, {Charlotte Ulrikka}",

year = "2024",

month = dec,

doi = "10.1007/s00431-024-05850-7",

language = "English",

volume = "184",

journal = "European Journal of Pediatrics",

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Infancy predictors of functional somatic symptoms in pre- and late adolescence: a longitudinal cohort study. / Münker, Lina; Rimvall, Martin Køster; Frostholm, Lisbeth et al.
In: European Journal of Pediatrics, Vol. 184, No. 1, 57, 12.2024.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Infancy predictors of functional somatic symptoms in pre- and late adolescence

T2 - a longitudinal cohort study

AU - Münker, Lina

AU - Rimvall, Martin Køster

AU - Frostholm, Lisbeth

AU - Ørnbøl, Eva

AU - Wellnitz, Kaare Bro

AU - Jeppesen, Pia

AU - Rosmalen, Judith Gerarda Maria

AU - Rask, Charlotte Ulrikka

PY - 2024/12

Y1 - 2024/12

N2 - Physiological regulatory problems in infancy (i.e., problems with sleeping, feeding, and tactile reactivity) have been associated with impairing functional somatic symptoms (FSS) at ages 5–7. We aimed to extend this finding by examining not only the association of physiological regulatory problems but also other infancy factors (i.e., emotion dysregulation and contact problems) with FSS in pre- and late adolescence. Standardized behavioral assessments and self-report questionnaire data from assessment waves at 0–1, 11–12, and 16–17 years of the population-based Copenhagen Child Cohort (CCC2000) were linked with Danish register data on maternal postpartum psychiatric illness and family adversity as covariates. Multiple linear regression analyses were performed to examine the association between infancy factors and FSS in pre- and late adolescence. Only infancy physiological regulatory problems significantly predicted preadolescent FSS (b = 0.38, 95% CI [0.14, 0.62]), also when accounting for maternal postpartum psychiatric illness and family adversity. The association was attenuated for late adolescent FSS. Conclusion: Infancy physiological regulatory problems may represent early signs of a dysregulated stress system and were found to significantly predict FSS in pre- but not late adolescence. Implications for early FSS prevention could include testing interventions promoting infants’ regulation of sleep, feeding, and tactile reactivity. (Table presented.)

AB - Physiological regulatory problems in infancy (i.e., problems with sleeping, feeding, and tactile reactivity) have been associated with impairing functional somatic symptoms (FSS) at ages 5–7. We aimed to extend this finding by examining not only the association of physiological regulatory problems but also other infancy factors (i.e., emotion dysregulation and contact problems) with FSS in pre- and late adolescence. Standardized behavioral assessments and self-report questionnaire data from assessment waves at 0–1, 11–12, and 16–17 years of the population-based Copenhagen Child Cohort (CCC2000) were linked with Danish register data on maternal postpartum psychiatric illness and family adversity as covariates. Multiple linear regression analyses were performed to examine the association between infancy factors and FSS in pre- and late adolescence. Only infancy physiological regulatory problems significantly predicted preadolescent FSS (b = 0.38, 95% CI [0.14, 0.62]), also when accounting for maternal postpartum psychiatric illness and family adversity. The association was attenuated for late adolescent FSS. Conclusion: Infancy physiological regulatory problems may represent early signs of a dysregulated stress system and were found to significantly predict FSS in pre- but not late adolescence. Implications for early FSS prevention could include testing interventions promoting infants’ regulation of sleep, feeding, and tactile reactivity. (Table presented.)

KW - Adolescent

KW - Family adversity

KW - Functional somatic symptoms

KW - Infancy contact problems

KW - Infancy emotion dysregulation

KW - Infancy physiological regulatory problems

KW - Maternal postpartum psychiatric illness

KW - Predictors

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U2 - 10.1007/s00431-024-05850-7

DO - 10.1007/s00431-024-05850-7

M3 - Journal article

C2 - 39621111

AN - SCOPUS:85211123476

SN - 0340-6199

VL - 184

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

IS - 1

M1 - 57

ER -

Infancy predictors of functional somatic symptoms in pre- and late adolescence: a longitudinal cohort study

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Keywords

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