Individual radiation response of parotid glands investigated by dynamic 11C-methionine PET

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BACKGROUND AND PURPOSE: Previously, we showed that the net metabolic clearance of 11C-methionine of the parotid gland, K, calculated from dynamic 11C-methionine PET, can be used as a measure of parotid gland function. The aim of this study was to investigate by dynamic 11C-methionine PET the individual radiation dose response relationship of parotid glands in head and neck cancer patients.

PATIENTS AND METHODS: Twelve head and neck cancer patients were examined by dynamic 11C-methionine PET after radiotherapy. Parametric images of K were generated, co-registered and compared voxel-by-voxel with the 3D radiation dose plan within the parotid gland to assess the individual radiation dose-function relationship.

RESULTS: In each patient, voxel-values of K decreased with increasing radiation dose. Population based analysis showed a sigmoid dose response relationship of parotid gland, from which we estimated a threshold radiation dose of 16 Gy and a mean TD50 of 30 Gy. TD50 ranged from 7 to 50 Gy in the group of patients.

CONCLUSIONS: Individual radiation dose response of parotid glands can be measured by dynamic 11C-methionine PET. The dose response analysis revealed a sigmoid relationship, a threshold radiation dose of 16 Gy, and a mean TD50 of 30 Gy.

Original languageEnglish
JournalRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Volume78
Issue3
Pages (from-to)262-9
Number of pages8
ISSN0167-8140
DOIs
Publication statusPublished - Mar 2006

    Research areas

  • Aged, Female, Head and Neck Neoplasms, Humans, Image Interpretation, Computer-Assisted, Male, Methionine, Middle Aged, Parotid Gland, Positron-Emission Tomography, Radiation Dosage, Radiometry, Radiopharmaceuticals, Relative Biological Effectiveness, Reproducibility of Results, Sensitivity and Specificity

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