Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry

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Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry. / Bonifazi, Martina; Sverzellati, Nicola; Negri, Eva; Pomponio, Giovanni; Seletti, Valeria; Bonini, Matteo; Fraticelli, Paolo; Paolini, Luca; Mattioli, Massimo; Franchi, Matteo; Tramacere, Irene; Poletti, Venerino; La Vecchia, Carlo; Gasparini, Stefano; Gabrielli, Armando.

In: Rheumatology (Oxford, England), Vol. 59, No. 3, 2020, p. 641-649.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Bonifazi, M, Sverzellati, N, Negri, E, Pomponio, G, Seletti, V, Bonini, M, Fraticelli, P, Paolini, L, Mattioli, M, Franchi, M, Tramacere, I, Poletti, V, La Vecchia, C, Gasparini, S & Gabrielli, A 2020, 'Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry', Rheumatology (Oxford, England), vol. 59, no. 3, pp. 641-649. https://doi.org/10.1093/rheumatology/kez340

APA

Bonifazi, M., Sverzellati, N., Negri, E., Pomponio, G., Seletti, V., Bonini, M., Fraticelli, P., Paolini, L., Mattioli, M., Franchi, M., Tramacere, I., Poletti, V., La Vecchia, C., Gasparini, S., & Gabrielli, A. (2020). Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry. Rheumatology (Oxford, England), 59(3), 641-649. https://doi.org/10.1093/rheumatology/kez340

CBE

Bonifazi M, Sverzellati N, Negri E, Pomponio G, Seletti V, Bonini M, Fraticelli P, Paolini L, Mattioli M, Franchi M, Tramacere I, Poletti V, La Vecchia C, Gasparini S, Gabrielli A. 2020. Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry. Rheumatology (Oxford, England). 59(3):641-649. https://doi.org/10.1093/rheumatology/kez340

MLA

Vancouver

Bonifazi M, Sverzellati N, Negri E, Pomponio G, Seletti V, Bonini M et al. Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry. Rheumatology (Oxford, England). 2020;59(3):641-649. https://doi.org/10.1093/rheumatology/kez340

Author

Bonifazi, Martina ; Sverzellati, Nicola ; Negri, Eva ; Pomponio, Giovanni ; Seletti, Valeria ; Bonini, Matteo ; Fraticelli, Paolo ; Paolini, Luca ; Mattioli, Massimo ; Franchi, Matteo ; Tramacere, Irene ; Poletti, Venerino ; La Vecchia, Carlo ; Gasparini, Stefano ; Gabrielli, Armando. / Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry. In: Rheumatology (Oxford, England). 2020 ; Vol. 59, No. 3. pp. 641-649.

Bibtex

@article{c4c064e7d07d4d68a0a13ae13528e814,
title = "Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry",
abstract = "OBJECTIVES: The prevalence and clinical implications of small airways involvement in SSc are still to be fully elucidated. The goal of the present work is to assess the prevalence of small airways dysfunction by impulse oscillometry and to determine whether it correlates with selected disease-related features and respiratory-related quality of life. METHODS: Ninety-four SSc patients and 93 healthy controls were studied by impulse oscillometry measurements. Small airways dysfunction was defined as the difference between resistance at low frequency, i.e. 5 Hz, and resistance at high frequency, i.e. 20 Hz, termed 'R5-R20', ⩾0.07 kPa/l/s. The St George's Respiratory Questionnaire was used to measure health impairment in SSc patients. Radiological features of small airways disease and parenchymal abnormalities on high resolution CT chest scans were jointly assessed by two thoracic radiologists. RESULTS: Small airways dysfunction was present in 21.5% of the SSc patient cohort, with a prevalence almost 5-fold higher compared with controls, and it was significantly associated with worse respiratory-related quality of life. Radiological features consistent with small airways abnormalities were detected in 25% of SSc patients, mostly in the absence of interstitial lung changes. Combining functional and radiological evaluations, one-third of the SSc cohort showed at least one feature of small airways involvement, which was associated with the lcSSc phenotype and with longer disease duration. CONCLUSION: The current study strengthens the hypothesis that small airway dysfunction might be a feature of SSc-related lung involvement, providing the first data on its significant impact on respiratory-related quality of life. A full assessment of lung function in SSc patients should include impulse oscillometry as a complementary technique, due to potential clinical and therapeutic implications.",
keywords = "impulse oscillometry, interstitial lung diseases, respiratory-related quality of life, scleroderma, small airway dysfunction",
author = "Martina Bonifazi and Nicola Sverzellati and Eva Negri and Giovanni Pomponio and Valeria Seletti and Matteo Bonini and Paolo Fraticelli and Luca Paolini and Massimo Mattioli and Matteo Franchi and Irene Tramacere and Venerino Poletti and {La Vecchia}, Carlo and Stefano Gasparini and Armando Gabrielli",
year = "2020",
doi = "10.1093/rheumatology/kez340",
language = "English",
volume = "59",
pages = "641--649",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry

AU - Bonifazi, Martina

AU - Sverzellati, Nicola

AU - Negri, Eva

AU - Pomponio, Giovanni

AU - Seletti, Valeria

AU - Bonini, Matteo

AU - Fraticelli, Paolo

AU - Paolini, Luca

AU - Mattioli, Massimo

AU - Franchi, Matteo

AU - Tramacere, Irene

AU - Poletti, Venerino

AU - La Vecchia, Carlo

AU - Gasparini, Stefano

AU - Gabrielli, Armando

PY - 2020

Y1 - 2020

N2 - OBJECTIVES: The prevalence and clinical implications of small airways involvement in SSc are still to be fully elucidated. The goal of the present work is to assess the prevalence of small airways dysfunction by impulse oscillometry and to determine whether it correlates with selected disease-related features and respiratory-related quality of life. METHODS: Ninety-four SSc patients and 93 healthy controls were studied by impulse oscillometry measurements. Small airways dysfunction was defined as the difference between resistance at low frequency, i.e. 5 Hz, and resistance at high frequency, i.e. 20 Hz, termed 'R5-R20', ⩾0.07 kPa/l/s. The St George's Respiratory Questionnaire was used to measure health impairment in SSc patients. Radiological features of small airways disease and parenchymal abnormalities on high resolution CT chest scans were jointly assessed by two thoracic radiologists. RESULTS: Small airways dysfunction was present in 21.5% of the SSc patient cohort, with a prevalence almost 5-fold higher compared with controls, and it was significantly associated with worse respiratory-related quality of life. Radiological features consistent with small airways abnormalities were detected in 25% of SSc patients, mostly in the absence of interstitial lung changes. Combining functional and radiological evaluations, one-third of the SSc cohort showed at least one feature of small airways involvement, which was associated with the lcSSc phenotype and with longer disease duration. CONCLUSION: The current study strengthens the hypothesis that small airway dysfunction might be a feature of SSc-related lung involvement, providing the first data on its significant impact on respiratory-related quality of life. A full assessment of lung function in SSc patients should include impulse oscillometry as a complementary technique, due to potential clinical and therapeutic implications.

AB - OBJECTIVES: The prevalence and clinical implications of small airways involvement in SSc are still to be fully elucidated. The goal of the present work is to assess the prevalence of small airways dysfunction by impulse oscillometry and to determine whether it correlates with selected disease-related features and respiratory-related quality of life. METHODS: Ninety-four SSc patients and 93 healthy controls were studied by impulse oscillometry measurements. Small airways dysfunction was defined as the difference between resistance at low frequency, i.e. 5 Hz, and resistance at high frequency, i.e. 20 Hz, termed 'R5-R20', ⩾0.07 kPa/l/s. The St George's Respiratory Questionnaire was used to measure health impairment in SSc patients. Radiological features of small airways disease and parenchymal abnormalities on high resolution CT chest scans were jointly assessed by two thoracic radiologists. RESULTS: Small airways dysfunction was present in 21.5% of the SSc patient cohort, with a prevalence almost 5-fold higher compared with controls, and it was significantly associated with worse respiratory-related quality of life. Radiological features consistent with small airways abnormalities were detected in 25% of SSc patients, mostly in the absence of interstitial lung changes. Combining functional and radiological evaluations, one-third of the SSc cohort showed at least one feature of small airways involvement, which was associated with the lcSSc phenotype and with longer disease duration. CONCLUSION: The current study strengthens the hypothesis that small airway dysfunction might be a feature of SSc-related lung involvement, providing the first data on its significant impact on respiratory-related quality of life. A full assessment of lung function in SSc patients should include impulse oscillometry as a complementary technique, due to potential clinical and therapeutic implications.

KW - impulse oscillometry

KW - interstitial lung diseases

KW - respiratory-related quality of life

KW - scleroderma

KW - small airway dysfunction

UR - http://www.scopus.com/inward/record.url?scp=85080846442&partnerID=8YFLogxK

U2 - 10.1093/rheumatology/kez340

DO - 10.1093/rheumatology/kez340

M3 - Journal article

C2 - 31436799

AN - SCOPUS:85080846442

VL - 59

SP - 641

EP - 649

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 3

ER -