Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau

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Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau. / Thomsen, Ditte; Hviid, Cecilie Juul; Hønge, Bo Langhoff; Medina, Candida; Té, David Da Silva; Correira, Faustino Gomes; Østergaard, Lars; Erikstrup, Christian; Wejse, Christian; Laursen, Alex Lund; Jespersen, Sanne.

In: Pan African Medical Journal, Vol. 29, 18, 2018, p. 18.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Author

Thomsen, Ditte ; Hviid, Cecilie Juul ; Hønge, Bo Langhoff ; Medina, Candida ; Té, David Da Silva ; Correira, Faustino Gomes ; Østergaard, Lars ; Erikstrup, Christian ; Wejse, Christian ; Laursen, Alex Lund ; Jespersen, Sanne. / Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau. In: Pan African Medical Journal. 2018 ; Vol. 29. pp. 18.

Bibtex

@article{41c341ca95904c78ae447e05f5c7bf36,
title = "Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau",
abstract = "Cryptococcal antigenemia may precede development of cryptococcal meningitis and death among patients with advanced HIV infection. Among 200 retrospectively and randomly selected ART-na{\"i}ve patients with CD4 counts < 100 cells/µl from Guinea-Bissau, 20 (10%) had a positive cryptococcal antigen test. Self-reported headache and fever were predictors of a positive test, while cryptococcal antigenemia was a strong predictor of death within the first year of follow-up, MRR 2.22 (95% CI: 1.15-4.30). Screening for cryptococcal antigenemia should be implemented for patients with advanced HIV in Guinea-Bissau. Pre-emptive anti-fungal therapy should be initiated prior to ART-initiation if the screening is positive.",
keywords = "AIDS-Related Opportunistic Infections/diagnosis, Adult, Antigens, Fungal/blood, CD4 Lymphocyte Count, Cryptococcus/isolation & purification, Female, Follow-Up Studies, Guinea-Bissau, HIV Infections/complications, Humans, Male, Meningitis, Cryptococcal/diagnosis, Retrospective Studies, Lateral flow assay, Antigen screening, Cryptococcal meningitis, HIV, Cryptococcal antigenemia",
author = "Ditte Thomsen and Hviid, {Cecilie Juul} and H{\o}nge, {Bo Langhoff} and Candida Medina and T{\'e}, {David Da Silva} and Correira, {Faustino Gomes} and Lars {\O}stergaard and Christian Erikstrup and Christian Wejse and Laursen, {Alex Lund} and Sanne Jespersen",
year = "2018",
doi = "10.11604/pamj.2018.29.18.14099",
language = "English",
volume = "29",
pages = "18",
journal = "Pan African Medical Journal",
issn = "1937-8688",
publisher = "African Field Epidemiology Network (A F E N E T)",

}

RIS

TY - JOUR

T1 - Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau

AU - Thomsen, Ditte

AU - Hviid, Cecilie Juul

AU - Hønge, Bo Langhoff

AU - Medina, Candida

AU - Té, David Da Silva

AU - Correira, Faustino Gomes

AU - Østergaard, Lars

AU - Erikstrup, Christian

AU - Wejse, Christian

AU - Laursen, Alex Lund

AU - Jespersen, Sanne

PY - 2018

Y1 - 2018

N2 - Cryptococcal antigenemia may precede development of cryptococcal meningitis and death among patients with advanced HIV infection. Among 200 retrospectively and randomly selected ART-naïve patients with CD4 counts < 100 cells/µl from Guinea-Bissau, 20 (10%) had a positive cryptococcal antigen test. Self-reported headache and fever were predictors of a positive test, while cryptococcal antigenemia was a strong predictor of death within the first year of follow-up, MRR 2.22 (95% CI: 1.15-4.30). Screening for cryptococcal antigenemia should be implemented for patients with advanced HIV in Guinea-Bissau. Pre-emptive anti-fungal therapy should be initiated prior to ART-initiation if the screening is positive.

AB - Cryptococcal antigenemia may precede development of cryptococcal meningitis and death among patients with advanced HIV infection. Among 200 retrospectively and randomly selected ART-naïve patients with CD4 counts < 100 cells/µl from Guinea-Bissau, 20 (10%) had a positive cryptococcal antigen test. Self-reported headache and fever were predictors of a positive test, while cryptococcal antigenemia was a strong predictor of death within the first year of follow-up, MRR 2.22 (95% CI: 1.15-4.30). Screening for cryptococcal antigenemia should be implemented for patients with advanced HIV in Guinea-Bissau. Pre-emptive anti-fungal therapy should be initiated prior to ART-initiation if the screening is positive.

KW - AIDS-Related Opportunistic Infections/diagnosis

KW - Adult

KW - Antigens, Fungal/blood

KW - CD4 Lymphocyte Count

KW - Cryptococcus/isolation & purification

KW - Female

KW - Follow-Up Studies

KW - Guinea-Bissau

KW - HIV Infections/complications

KW - Humans

KW - Male

KW - Meningitis, Cryptococcal/diagnosis

KW - Retrospective Studies

KW - Lateral flow assay

KW - Antigen screening

KW - Cryptococcal meningitis

KW - HIV

KW - Cryptococcal antigenemia

UR - http://www.scopus.com/inward/record.url?scp=85041735724&partnerID=8YFLogxK

U2 - 10.11604/pamj.2018.29.18.14099

DO - 10.11604/pamj.2018.29.18.14099

M3 - Journal article

C2 - 29662603

VL - 29

SP - 18

JO - Pan African Medical Journal

JF - Pan African Medical Journal

SN - 1937-8688

M1 - 18

ER -