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Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau

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Standard

Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau. / Thomsen, Ditte; Hviid, Cecilie Juul; Hønge, Bo Langhoff; Medina, Candida; Té, David Da Silva; Correira, Faustino Gomes; Østergaard, Lars; Erikstrup, Christian; Wejse, Christian; Laursen, Alex Lund; Jespersen, Sanne.

In: Pan African Medical Journal, Vol. 29, 18, 2018, p. 18.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Thomsen, D, Hviid, CJ, Hønge, BL, Medina, C, Té, DDS, Correira, FG, Østergaard, L, Erikstrup, C, Wejse, C, Laursen, AL & Jespersen, S 2018, 'Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau', Pan African Medical Journal, vol. 29, 18, pp. 18. https://doi.org/10.11604/pamj.2018.29.18.14099

APA

Thomsen, D., Hviid, C. J., Hønge, B. L., Medina, C., Té, D. D. S., Correira, F. G., Østergaard, L., Erikstrup, C., Wejse, C., Laursen, A. L., & Jespersen, S. (2018). Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau. Pan African Medical Journal, 29, 18. [18]. https://doi.org/10.11604/pamj.2018.29.18.14099

CBE

Thomsen D, Hviid CJ, Hønge BL, Medina C, Té DDS, Correira FG, Østergaard L, Erikstrup C, Wejse C, Laursen AL, Jespersen S. 2018. Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau. Pan African Medical Journal. 29:18. https://doi.org/10.11604/pamj.2018.29.18.14099

MLA

Thomsen, Ditte et al. "Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau". Pan African Medical Journal. 2018, 29. 18. https://doi.org/10.11604/pamj.2018.29.18.14099

Vancouver

Thomsen D, Hviid CJ, Hønge BL, Medina C, Té DDS, Correira FG et al. Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau. Pan African Medical Journal. 2018;29:18. 18. https://doi.org/10.11604/pamj.2018.29.18.14099

Author

Thomsen, Ditte ; Hviid, Cecilie Juul ; Hønge, Bo Langhoff ; Medina, Candida ; Té, David Da Silva ; Correira, Faustino Gomes ; Østergaard, Lars ; Erikstrup, Christian ; Wejse, Christian ; Laursen, Alex Lund ; Jespersen, Sanne. / Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau. In: Pan African Medical Journal. 2018 ; Vol. 29. pp. 18.

Bibtex

@article{41c341ca95904c78ae447e05f5c7bf36,
title = "Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau",
abstract = "Cryptococcal antigenemia may precede development of cryptococcal meningitis and death among patients with advanced HIV infection. Among 200 retrospectively and randomly selected ART-na{\"i}ve patients with CD4 counts < 100 cells/µl from Guinea-Bissau, 20 (10%) had a positive cryptococcal antigen test. Self-reported headache and fever were predictors of a positive test, while cryptococcal antigenemia was a strong predictor of death within the first year of follow-up, MRR 2.22 (95% CI: 1.15-4.30). Screening for cryptococcal antigenemia should be implemented for patients with advanced HIV in Guinea-Bissau. Pre-emptive anti-fungal therapy should be initiated prior to ART-initiation if the screening is positive.",
keywords = "AIDS-Related Opportunistic Infections/diagnosis, Adult, Antigens, Fungal/blood, CD4 Lymphocyte Count, Cryptococcus/isolation & purification, Female, Follow-Up Studies, Guinea-Bissau, HIV Infections/complications, Humans, Male, Meningitis, Cryptococcal/diagnosis, Retrospective Studies, Lateral flow assay, Antigen screening, Cryptococcal meningitis, HIV, Cryptococcal antigenemia",
author = "Ditte Thomsen and Hviid, {Cecilie Juul} and H{\o}nge, {Bo Langhoff} and Candida Medina and T{\'e}, {David Da Silva} and Correira, {Faustino Gomes} and Lars {\O}stergaard and Christian Erikstrup and Christian Wejse and Laursen, {Alex Lund} and Sanne Jespersen",
year = "2018",
doi = "10.11604/pamj.2018.29.18.14099",
language = "English",
volume = "29",
pages = "18",
journal = "Pan African Medical Journal",
issn = "1937-8688",
publisher = "African Field Epidemiology Network (A F E N E T)",

}

RIS

TY - JOUR

T1 - Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau

AU - Thomsen, Ditte

AU - Hviid, Cecilie Juul

AU - Hønge, Bo Langhoff

AU - Medina, Candida

AU - Té, David Da Silva

AU - Correira, Faustino Gomes

AU - Østergaard, Lars

AU - Erikstrup, Christian

AU - Wejse, Christian

AU - Laursen, Alex Lund

AU - Jespersen, Sanne

PY - 2018

Y1 - 2018

N2 - Cryptococcal antigenemia may precede development of cryptococcal meningitis and death among patients with advanced HIV infection. Among 200 retrospectively and randomly selected ART-naïve patients with CD4 counts < 100 cells/µl from Guinea-Bissau, 20 (10%) had a positive cryptococcal antigen test. Self-reported headache and fever were predictors of a positive test, while cryptococcal antigenemia was a strong predictor of death within the first year of follow-up, MRR 2.22 (95% CI: 1.15-4.30). Screening for cryptococcal antigenemia should be implemented for patients with advanced HIV in Guinea-Bissau. Pre-emptive anti-fungal therapy should be initiated prior to ART-initiation if the screening is positive.

AB - Cryptococcal antigenemia may precede development of cryptococcal meningitis and death among patients with advanced HIV infection. Among 200 retrospectively and randomly selected ART-naïve patients with CD4 counts < 100 cells/µl from Guinea-Bissau, 20 (10%) had a positive cryptococcal antigen test. Self-reported headache and fever were predictors of a positive test, while cryptococcal antigenemia was a strong predictor of death within the first year of follow-up, MRR 2.22 (95% CI: 1.15-4.30). Screening for cryptococcal antigenemia should be implemented for patients with advanced HIV in Guinea-Bissau. Pre-emptive anti-fungal therapy should be initiated prior to ART-initiation if the screening is positive.

KW - AIDS-Related Opportunistic Infections/diagnosis

KW - Adult

KW - Antigens, Fungal/blood

KW - CD4 Lymphocyte Count

KW - Cryptococcus/isolation & purification

KW - Female

KW - Follow-Up Studies

KW - Guinea-Bissau

KW - HIV Infections/complications

KW - Humans

KW - Male

KW - Meningitis, Cryptococcal/diagnosis

KW - Retrospective Studies

KW - Lateral flow assay

KW - Antigen screening

KW - Cryptococcal meningitis

KW - HIV

KW - Cryptococcal antigenemia

UR - http://www.scopus.com/inward/record.url?scp=85041735724&partnerID=8YFLogxK

U2 - 10.11604/pamj.2018.29.18.14099

DO - 10.11604/pamj.2018.29.18.14099

M3 - Journal article

C2 - 29662603

VL - 29

SP - 18

JO - Pan African Medical Journal

JF - Pan African Medical Journal

SN - 1937-8688

M1 - 18

ER -