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Increased In Vivo Thrombin Generation in Patients with Localized Non-Small Cell Lung Cancer Unfit for Surgery

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  • Johanne Andersen Hojbjerg
  • Kristian Kirkelund Bentsen, University of Southern Denmark
  • ,
  • Pernille Just Vinholt, University of Southern Denmark
  • ,
  • Olfred Hansen, University of Southern Denmark
  • ,
  • Stefan Starup Jeppesen, University of Southern Denmark
  • ,
  • Anne Mette Hvas

Patients with lung cancer face a substantially increased risk of thromboembolic disease. Patients with localized non-small cell lung cancer (NSCLC) who are unfit for surgery due to age or comorbidity have additional thrombotic risk factors. Thus, we aimed to investigate markers of primary and secondary hemostasis, since this could assist in treatment decisions. We included 105 patients with localized NSCLC. Ex vivo thrombin generation was determined by calibrated automated thrombogram and in vivo thrombin generation was determined by measurement of thrombin–antithrombin complex (TAT) levels and prothrombin fragment F1 + 2 concentrations (F1 + 2). Platelet aggregation was investigated by impedance aggregometry. Healthy controls were used for comparison. TAT and F1 + 2 concentrations were significantly higher in NSCLC patients than in healthy controls (P <.001). The levels of ex vivo thrombin generation and platelet aggregation were not increased in the NSCLC patients. Patients with localized NSCLC considered unfit for surgery had significantly increased in vivo thrombin generation. This finding should be further investigated as it could be relevant for the choice of thromboprophylaxis in these patients.

Original languageEnglish
JournalClinical and Applied Thrombosis/Hemostasis
Number of pages6
Publication statusPublished - Jan 2023

Bibliographical note

Publisher Copyright:
© The Author(s) 2023.

    Research areas

  • hemostasis, lung neoplasms, platelet aggregation, thrombin generation

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