Aarhus University Seal / Aarhus Universitets segl

Increased IL-25 levels in the peritoneal fluid of patients with endometriosis

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

Increased IL-25 levels in the peritoneal fluid of patients with endometriosis. / Bungum, Helle Folge; Nygaard, Uffe; Vestergaard, Christian; Martensen, Pia M; Knudsen, Ulla Breth.

In: Journal of Reproductive Immunology, Vol. 114, 22.01.2016, p. 6-9.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

APA

CBE

MLA

Bungum, Helle Folge et al. "Increased IL-25 levels in the peritoneal fluid of patients with endometriosis". Journal of Reproductive Immunology. 2016, 114. 6-9. https://doi.org/10.1016/j.jri.2016.01.003

Vancouver

Author

Bibtex

@article{544be17fa1f440148d81a42fb13fc95c,
title = "Increased IL-25 levels in the peritoneal fluid of patients with endometriosis",
abstract = "Previous studies have indicated a higher prevalence of allergic disease among women with endometriosis. It is already well established that type 1 allergies develop in a Th2 cytokine environment. Recent studies have shown, however, that IL-25 induces a Th2 development of naive T lymphocytes and is central in the Th2 response. The aim of this case-control study was to investigate the presence of IL-25 in the peritoneal fluid of women suffering from endometriosis. PF was obtained both from women undergoing laparoscopic surgery due to endometriosis (25 cases) and from women wanting sterilisation (19 controls). IL-25 levels were then investigated by ELISA. Women with endometriosis showed significantly higher levels of IL-25 in their PF (p=0.019) compared to controls. IL-25 levels did not correlate with the stage of endometriosis. Both Th2-cells and mast cells express IL-25, which could favor the development of allergies by perpetuating a hypersensitivity reaction. Further, IL-25 may also hold a role as a diagnostic tool.",
author = "Bungum, {Helle Folge} and Uffe Nygaard and Christian Vestergaard and Martensen, {Pia M} and Knudsen, {Ulla Breth}",
note = "Copyright {\circledC} 2016. Published by Elsevier Ireland Ltd.",
year = "2016",
month = "1",
day = "22",
doi = "10.1016/j.jri.2016.01.003",
language = "English",
volume = "114",
pages = "6--9",
journal = "Journal of Reproductive Immunology",
issn = "0165-0378",
publisher = "Elsevier Ireland Ltd.",

}

RIS

TY - JOUR

T1 - Increased IL-25 levels in the peritoneal fluid of patients with endometriosis

AU - Bungum, Helle Folge

AU - Nygaard, Uffe

AU - Vestergaard, Christian

AU - Martensen, Pia M

AU - Knudsen, Ulla Breth

N1 - Copyright © 2016. Published by Elsevier Ireland Ltd.

PY - 2016/1/22

Y1 - 2016/1/22

N2 - Previous studies have indicated a higher prevalence of allergic disease among women with endometriosis. It is already well established that type 1 allergies develop in a Th2 cytokine environment. Recent studies have shown, however, that IL-25 induces a Th2 development of naive T lymphocytes and is central in the Th2 response. The aim of this case-control study was to investigate the presence of IL-25 in the peritoneal fluid of women suffering from endometriosis. PF was obtained both from women undergoing laparoscopic surgery due to endometriosis (25 cases) and from women wanting sterilisation (19 controls). IL-25 levels were then investigated by ELISA. Women with endometriosis showed significantly higher levels of IL-25 in their PF (p=0.019) compared to controls. IL-25 levels did not correlate with the stage of endometriosis. Both Th2-cells and mast cells express IL-25, which could favor the development of allergies by perpetuating a hypersensitivity reaction. Further, IL-25 may also hold a role as a diagnostic tool.

AB - Previous studies have indicated a higher prevalence of allergic disease among women with endometriosis. It is already well established that type 1 allergies develop in a Th2 cytokine environment. Recent studies have shown, however, that IL-25 induces a Th2 development of naive T lymphocytes and is central in the Th2 response. The aim of this case-control study was to investigate the presence of IL-25 in the peritoneal fluid of women suffering from endometriosis. PF was obtained both from women undergoing laparoscopic surgery due to endometriosis (25 cases) and from women wanting sterilisation (19 controls). IL-25 levels were then investigated by ELISA. Women with endometriosis showed significantly higher levels of IL-25 in their PF (p=0.019) compared to controls. IL-25 levels did not correlate with the stage of endometriosis. Both Th2-cells and mast cells express IL-25, which could favor the development of allergies by perpetuating a hypersensitivity reaction. Further, IL-25 may also hold a role as a diagnostic tool.

U2 - 10.1016/j.jri.2016.01.003

DO - 10.1016/j.jri.2016.01.003

M3 - Journal article

C2 - 26852387

VL - 114

SP - 6

EP - 9

JO - Journal of Reproductive Immunology

JF - Journal of Reproductive Immunology

SN - 0165-0378

ER -