Increased cerebral oxygen extraction capacity in patients with Alzheimer’s disease

Simon Fristed Eskildsen; Louise Gyldensted; Kartheeban Nagenthiraja; Jesper Frandsen; Anders Rodell; Carsten Gyldensted; Sune Nørhøj Jespersen; Kim Mouridsen; Hans Brændgaard; Leif Østergaard

doi:10.1016/j.jalz.2013.05.173

Increased cerebral oxygen extraction capacity in patients with Alzheimer’s disease

Simon Fristed Eskildsen, Louise Gyldensted, Kartheeban Nagenthiraja, Jesper Frandsen, Anders Rodell, Carsten Gyldensted, Sune Nørhøj Jespersen, Kim Mouridsen, Hans Brændgaard, Leif Østergaard

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Abstract

Vascular risk factors are suspected to play a role in the etiology of Alzheimer’s disease. Recently, a model that relates capillary dysfunction to the development of AD was proposed [1]. The model predicts that increased capillary dysfunction leads to increased oxygen extraction in order to support the metabolic requirements of the brain tissues. In this study we investigated the brain oxygen extraction capacity (OEFmax) in AD patients and controls using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI).

Increased OEFmax was detected in the temporal, parietal and frontal lobes of AD patients compared to controls. These findings are consistent with the capillary dysfunction hypothesis of AD [1]. The widespread cortical atrophy and smaller hippocampal volumes in the AD patients suggest pathologies of late Braak stages. Further studies should address the causal relation between elevated OEFmax and atrophy.

Original language	English
Publication date	14 Jul 2013
Number of pages	1
DOIs	https://doi.org/10.1016/j.jalz.2013.05.173
Publication status	Published - 14 Jul 2013
Event	Alzheimer's Association International Conference - Boston, United States Duration: 13 Jul 2013 → 18 Jul 2013

Conference

Conference	Alzheimer's Association International Conference
Country/Territory	United States
City	Boston
Period	13/07/2013 → 18/07/2013

Keywords

Alzheimer
perfusion
MRI
OEF
capillary dysfunction

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10.1016/j.jalz.2013.05.173

AAIC2013-poster-AD-OEFSubmitted manuscript, 2.39 MB

http://www.alzheimersanddementia.com/article/S1552-5260(13)00830-3/fulltext

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Eskildsen, S. F., Gyldensted, L., Nagenthiraja, K., Frandsen, J., Rodell, A., Gyldensted, C., Jespersen, S. N., Mouridsen, K., Brændgaard, H., & Østergaard, L. (2013). Increased cerebral oxygen extraction capacity in patients with Alzheimer’s disease. Abstract from Alzheimer's Association International Conference, Boston, United States. https://doi.org/10.1016/j.jalz.2013.05.173

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abstract = "Vascular risk factors are suspected to play a role in the etiology of Alzheimer{\textquoteright}s disease. Recently, a model that relates capillary dysfunction to the development of AD was proposed [1]. The model predicts that increased capillary dysfunction leads to increased oxygen extraction in order to support the metabolic requirements of the brain tissues. In this study we investigated the brain oxygen extraction capacity (OEFmax) in AD patients and controls using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI).Increased OEFmax was detected in the temporal, parietal and frontal lobes of AD patients compared to controls. These findings are consistent with the capillary dysfunction hypothesis of AD [1]. The widespread cortical atrophy and smaller hippocampal volumes in the AD patients suggest pathologies of late Braak stages. Further studies should address the causal relation between elevated OEFmax and atrophy.",

keywords = "Alzheimer, perfusion, MRI, OEF, capillary dysfunction",

author = "Eskildsen, {Simon Fristed} and Louise Gyldensted and Kartheeban Nagenthiraja and Jesper Frandsen and Anders Rodell and Carsten Gyldensted and Jespersen, {Sune N{\o}rh{\o}j} and Kim Mouridsen and Hans Br{\ae}ndgaard and Leif {\O}stergaard",

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doi = "10.1016/j.jalz.2013.05.173",

language = "English",

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Eskildsen, SF, Gyldensted, L, Nagenthiraja, K, Frandsen, J, Rodell, A, Gyldensted, C , Jespersen, SN , Mouridsen, K, Brændgaard, H & Østergaard, L 2013, 'Increased cerebral oxygen extraction capacity in patients with Alzheimer’s disease', Alzheimer's Association International Conference, Boston, United States, 13/07/2013 - 18/07/2013. https://doi.org/10.1016/j.jalz.2013.05.173

TY - ABST

T1 - Increased cerebral oxygen extraction capacity in patients with Alzheimer’s disease

AU - Eskildsen, Simon Fristed

AU - Gyldensted, Louise

AU - Nagenthiraja, Kartheeban

AU - Frandsen, Jesper

AU - Rodell, Anders

AU - Gyldensted, Carsten

AU - Jespersen, Sune Nørhøj

AU - Mouridsen, Kim

AU - Brændgaard, Hans

AU - Østergaard, Leif

PY - 2013/7/14

Y1 - 2013/7/14

N2 - Vascular risk factors are suspected to play a role in the etiology of Alzheimer’s disease. Recently, a model that relates capillary dysfunction to the development of AD was proposed [1]. The model predicts that increased capillary dysfunction leads to increased oxygen extraction in order to support the metabolic requirements of the brain tissues. In this study we investigated the brain oxygen extraction capacity (OEFmax) in AD patients and controls using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI).Increased OEFmax was detected in the temporal, parietal and frontal lobes of AD patients compared to controls. These findings are consistent with the capillary dysfunction hypothesis of AD [1]. The widespread cortical atrophy and smaller hippocampal volumes in the AD patients suggest pathologies of late Braak stages. Further studies should address the causal relation between elevated OEFmax and atrophy.

AB - Vascular risk factors are suspected to play a role in the etiology of Alzheimer’s disease. Recently, a model that relates capillary dysfunction to the development of AD was proposed [1]. The model predicts that increased capillary dysfunction leads to increased oxygen extraction in order to support the metabolic requirements of the brain tissues. In this study we investigated the brain oxygen extraction capacity (OEFmax) in AD patients and controls using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI).Increased OEFmax was detected in the temporal, parietal and frontal lobes of AD patients compared to controls. These findings are consistent with the capillary dysfunction hypothesis of AD [1]. The widespread cortical atrophy and smaller hippocampal volumes in the AD patients suggest pathologies of late Braak stages. Further studies should address the causal relation between elevated OEFmax and atrophy.

KW - Alzheimer

KW - perfusion

KW - MRI

KW - OEF

KW - capillary dysfunction

U2 - 10.1016/j.jalz.2013.05.173

DO - 10.1016/j.jalz.2013.05.173

M3 - Conference abstract for conference

T2 - Alzheimer's Association International Conference

Y2 - 13 July 2013 through 18 July 2013

ER -

Increased cerebral oxygen extraction capacity in patients with Alzheimer’s disease

Abstract

Conference

Keywords

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