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Increased activity of the mannan-binding lectin complement activation pathway in patients with colorectal cancer

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Postoperative bacterial infectious complications are frequent in patients with colorectal cancer (CRC), with subsequent increased recurrence rates and poor prognosis. Deficiency of the mannan-binding lectin (MBL) complement activation pathway may cause increased risk of infection in certain patient groups. It is hypothesized that a deficient MBL pathway might be more frequent among patients with CRC than in healthy individuals. The MBL pathway was therefore evaluated in serum obtained preoperatively from 193 patients with primary CRC and in serum from 150 healthy volunteers.
Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Pages (from-to)674-9
Number of pages6
Publication statusPublished - 2004

    Research areas

  • Adult, Age Factors, Aged, Aged, 80 and over, Case-Control Studies, Colonic Neoplasms, Complement Pathway, Mannose-Binding Lectin, Female, Humans, Male, Mannose-Binding Lectin, Mannose-Binding Protein-Associated Serine Proteases, Middle Aged, Rectal Neoplasms, Serine Endopeptidases

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