Incidence, Frequency, and Clinical Characteristics of Type 3 Myocardial Infarction in Clinical Practice

Nikolaj Jangaard, Laura Sarkisian, Lotte Saaby, Søren Mikkelsen, Anne Marie Lassen, Niels Marcussen, Jørgen L Thomsen, Axel C P Diederichsen, Kristian Thygesen, Hans Mickley

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

12 Citations (Scopus)

Abstract

OBJECTIVES: Cardiac death in a patient with symptoms and electrocardiographic changes indicative of myocardial ischemia but without available measurements of cardiac biomarkers is designated a type 3 myocardial infarction. We wanted to investigate the incidence, the frequency, and the characteristics of patients diagnosed as type 3 myocardial infarction.

METHODS: The occurrence of deaths in a well-defined geographic region was retrieved from the Danish Civil Registration System during a 1-year period from 2010 to 2011. Complementary data concerning causes of deaths were obtained from the Danish Register of Causes of Death, and ambulance and hospital patient files. Adjudication of the diagnosis was done by 2 local experts and one external senior cardiologist.

RESULTS: A total of 2766 of the 246,723 adult residents in the region had died. A type 3 myocardial infarction was diagnosed in 18 individuals, corresponding to an annual incidence of 7.3/100,000 person-years. During the same 1-year period, 488 patients had other types of myocardial infarction implying a 3.6% frequency of type 3 myocardial infarction (18 of 506) among all myocardial infarctions.

CONCLUSION: Type 3 myocardial infarction is a rare observation in clinical practice with an annual incidence below 10/100,000 person-years and a frequency of 3%-4% among all types of myocardial infarction. If autopsy data are included, the number of type 3 myocardial infarctions will increase.

Original languageEnglish
Article numberARTN 862. e9
JournalAmerican Journal of Medicine
Volume130
Issue7
Pages (from-to)862.e9-862.e14
Number of pages6
ISSN0002-9343
DOIs
Publication statusPublished - Jul 2017

Keywords

  • Aged
  • Autopsy
  • Biomarkers
  • Denmark
  • Female
  • Hospital Mortality
  • Humans
  • Incidence
  • Male
  • Myocardial Infarction
  • Retrospective Studies
  • Troponin I
  • Journal Article

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