In vivo imaging of microglial activation with [11C](R -PK11195 PET in corticobasal degeneration

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  • Alexander Gerhard, Imperial College London, London, UK., Hammersmith Hospital
  • ,
  • Justin Watts, Imperial College London, London, UK., Emory University School of Medicine
  • ,
  • Iris Trender-Gerhard, MRC Prion Unit, Institute of Neurology
  • ,
  • Federico Turkheimer, Imperial College London, London, UK.
  • ,
  • Richard B. Banati, Imperial College London, London, UK.
  • ,
  • Kailash Bhatia, MRC Prion Unit, Institute of Neurology
  • ,
  • David J. Brooks

Corticobasal degeneration (CBD) is a neurodegenerative parkinsonian disorder of unknown cause that shows considerable clinical heterogeneity. In CBD, activated microglia have been shown to the associated closely with the extensive tau pathologgy found in the affected basal ganglia, brainstem nuclei, and cortical regions. We report on the use of [11C](R -(1-[2-chlorophenyl]-N-methyl-N-[1-methytpropyl]-3-isoquinoline carboxamide) (PK11195) positron emission tomography (PET), a marker of peripheral benzodiazepine binding sites (PBBS) that are expressed by activated microglia, to demonstrate in vivo the degree and distribution of glial response to the degenerative process in 4 patients with CBD. Compared with normal age-matched controls, the CBD patient group showed significantly increased mean [11-C](R)-PK11195 binding in the caudate nucleus, putamen, substantia nigra, pons, pre- and postcentral gyrus, and the frontal lobe. [11C](R)-PK11195 PET reveals a pattern of increased microglial activation in CBD patients involving cortical regions and the basal ganglia that corresponds well with the know distribution of neuropathological changes, which may therefore help to characterize in vivo the underlying disease activity in CBD.

Original languageEnglish
JournalMovement Disorders
Pages (from-to)1221-1226
Number of pages6
Publication statusPublished - 1 Oct 2004
Externally publishedYes

    Research areas

  • [C](R)-PK11195 PET, Activated microglia, Corticobasal degeneration

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