In vivo imaging of microglial activation with [11C]-PK11195 PET progresive supranuclear palsy

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Alexander Gerhard, Imperial College London, London, UK., Hammersmith Hospital
  • ,
  • Iris Trender-Gerhard, Imperial College London, London, UK., Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
  • ,
  • Federico Turkheimer, Imperial College London, London, UK.
  • ,
  • Niall P. Quinn, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
  • ,
  • Kailash P. Bhatia, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London
  • ,
  • David J. Brooks

Progressive supranuclear palsy (PSP) is a neurodegenerative disease presenting with voluntary gaze difficulties, early falls, and Parkinsonism. Neuronal loss, associated with intracellular neurofibrillary tangles and activated microglia, is found targeting the basal ganglia, brainstem nuclei, and frontal cortex. [11C](R)-PK11195 PET is a marker of peripheral benzodiazepine binding sites (PBBS) expressed by activated microglia. We have used [11C](R)-PK11195 PET to demonstrate in vivo the degree and distribution of the glial response to the degenerative process in four patients with PSP. Compared to normal age-matched controls, the PSP patient group showed significantly increased mean [11C](R)-PK11195 binding in the basal ganglia, midbrain, the frontal lobe, and the cerebellum. Two of the patients were rescanned after 6 to 10 months and during that time the level of microglial activation remained stable. [11C](R)-PK11195 PET reveals a pattern of increased microglial activation in PSP patients involving cortical and subcortical regions that corresponds well with the known distribution of neuropathological changes. [11C](R)-PK11195 PET, therefore, may help in characterizing in vivo the underlying disease activity in PSP.

Original languageEnglish
JournalMovement Disorders
Volume21
Issue1
Pages (from-to)89-93
Number of pages5
ISSN0885-3185
DOIs
Publication statusPublished - 1 Jan 2006
Externally publishedYes

    Research areas

  • [C]-PK11195 PET, Activated microglia, Progressive supranuclear palsy

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