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Improving prediction of Alzheimer’s disease using patterns of cortical thinning and homogenizing images according to disease stage

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  • Simon Fristed Eskildsen
  • Pierrick Coupé
  • ,
  • Daniel García-Lorenzo
  • ,
  • Vladimir Fonov
  • ,
  • Jens C. Pruessner
  • ,
  • D. Louis Collins
Predicting Alzheimer’s disease (AD) in individuals with some symptoms of cognitive decline may have great influence on treatment choice and guide subject selection in trials on disease modifying drugs. Structural MRI has the potential of revealing early signs of neurodegeneration in the human brain and may thus aid in predicting and diagnosing AD. Surface-based cortical thickness measurements from T1-weighted MRI have demonstrated high sensitivity to cortical gray matter changes. In this study, we investigated the possibility of using patterns of cortical thickness measurements for predicting AD in subjects with mild cognitive impairment (MCI). Specific patterns of atrophy were identified at four time periods before diagnosis of probable AD and features were selected as regions of interest within these patterns. The selected regions were used for cortical thickness measurements and applied in a classifier for testing the ability to predict AD at the four stages. The accuracy of the prediction improved as the time to conversion from MCI to AD decreased, from 70% at 3 years before the clinical criteria for AD was met, to 76% at 6 months before AD. These results show that prediction accuracies of conversion from MCI to AD can be improved by learning the atrophy patterns that are specific to the different stages of disease progression. This has the potential to guide the further development of imaging biomarkers in AD.
Original languageEnglish
Publication year5 Oct 2012
Number of pages12
Publication statusPublished - 5 Oct 2012
EventMedical Image Computing and Computer Assisted Intervention: 2012 - Nice, France
Duration: 1 Oct 20125 Oct 2012
Conference number: 15


ConferenceMedical Image Computing and Computer Assisted Intervention

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