Improved perfusion quantification in FAIR imaging by offset correction

K Sidaros; Irene Klærke Andersen; H Gesmar; E Rostrup; H B Larsson

Improved perfusion quantification in FAIR imaging by offset correction

K Sidaros, Irene Klærke Andersen, H Gesmar, E Rostrup, H B Larsson

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Perfusion quantification using pulsed arterial spin labeling has been shown to be sensitive to the RF pulse slice profiles. Therefore, in Flow-sensitive Alternating-Inversion Recovery (FAIR) imaging the slice selective (ss) inversion slab is usually three to four times thicker than the imaging slice. However, this reduces perfusion sensitivity due to the increased transit delay of the incoming blood with unperturbed spins. In the present article, the dependence of the magnetization on the RF pulse slice profiles is inspected both theoretically and experimentally. A perfusion quantification model is presented that allows the use of thinner ss inversion slabs by taking into account the offset of RF slice profiles between ss and nonselective inversion slabs. This model was tested in both phantom and human studies. Magn Reson Med 46:193-197, 2001.

Original language	English
Journal	Magnetic Resonance in Medicine
Volume	46
Issue	1
Pages (from-to)	193-7
Number of pages	5
ISSN	0740-3194
Publication status	Published - Jul 2001
Externally published	Yes

Keywords

Adult
Brain/anatomy & histology
Humans
Magnetic Resonance Imaging/methods
Phantoms, Imaging
Spin Labels

Cite this

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title = "Improved perfusion quantification in FAIR imaging by offset correction",

abstract = "Perfusion quantification using pulsed arterial spin labeling has been shown to be sensitive to the RF pulse slice profiles. Therefore, in Flow-sensitive Alternating-Inversion Recovery (FAIR) imaging the slice selective (ss) inversion slab is usually three to four times thicker than the imaging slice. However, this reduces perfusion sensitivity due to the increased transit delay of the incoming blood with unperturbed spins. In the present article, the dependence of the magnetization on the RF pulse slice profiles is inspected both theoretically and experimentally. A perfusion quantification model is presented that allows the use of thinner ss inversion slabs by taking into account the offset of RF slice profiles between ss and nonselective inversion slabs. This model was tested in both phantom and human studies. Magn Reson Med 46:193-197, 2001.",

keywords = "Adult, Brain/anatomy & histology, Humans, Magnetic Resonance Imaging/methods, Phantoms, Imaging, Spin Labels",

author = "K Sidaros and Andersen, {Irene Kl{\ae}rke} and H Gesmar and E Rostrup and Larsson, {H B}",

year = "2001",

month = jul,

language = "English",

volume = "46",

pages = "193--7",

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TY - JOUR

T1 - Improved perfusion quantification in FAIR imaging by offset correction

AU - Sidaros, K

AU - Andersen, Irene Klærke

AU - Gesmar, H

AU - Rostrup, E

AU - Larsson, H B

PY - 2001/7

Y1 - 2001/7

N2 - Perfusion quantification using pulsed arterial spin labeling has been shown to be sensitive to the RF pulse slice profiles. Therefore, in Flow-sensitive Alternating-Inversion Recovery (FAIR) imaging the slice selective (ss) inversion slab is usually three to four times thicker than the imaging slice. However, this reduces perfusion sensitivity due to the increased transit delay of the incoming blood with unperturbed spins. In the present article, the dependence of the magnetization on the RF pulse slice profiles is inspected both theoretically and experimentally. A perfusion quantification model is presented that allows the use of thinner ss inversion slabs by taking into account the offset of RF slice profiles between ss and nonselective inversion slabs. This model was tested in both phantom and human studies. Magn Reson Med 46:193-197, 2001.

AB - Perfusion quantification using pulsed arterial spin labeling has been shown to be sensitive to the RF pulse slice profiles. Therefore, in Flow-sensitive Alternating-Inversion Recovery (FAIR) imaging the slice selective (ss) inversion slab is usually three to four times thicker than the imaging slice. However, this reduces perfusion sensitivity due to the increased transit delay of the incoming blood with unperturbed spins. In the present article, the dependence of the magnetization on the RF pulse slice profiles is inspected both theoretically and experimentally. A perfusion quantification model is presented that allows the use of thinner ss inversion slabs by taking into account the offset of RF slice profiles between ss and nonselective inversion slabs. This model was tested in both phantom and human studies. Magn Reson Med 46:193-197, 2001.

KW - Adult

KW - Brain/anatomy & histology

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Phantoms, Imaging

KW - Spin Labels

M3 - Journal article

C2 - 11443727

SN - 0740-3194

VL - 46

SP - 193

EP - 197

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 1

ER -

Improved perfusion quantification in FAIR imaging by offset correction

Abstract

Keywords

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