Improved estimates for the role of grey matter volume and GABA in bistable perception

K. Sandberg, J.U. Blicher, S.H. Del Pin, L.M. Andersen, G. Rees, R. Kanai

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Abstract

Across a century or more, ambiguous stimuli have been studied scientifically because they provide a method for studying the internal mechanisms of the brain while ensuring an unchanging external stimulus. In recent years, several studies have reported correlations between perceptual dynamics during bistable perception and particular brain characteristics such as the grey matter volume of areas in the superior parietal lobule (SPL) and the relative GABA concentration in the occipital lobe. Here, we attempt to replicate previous results using similar paradigms to those used in the studies first reporting the correlations. Using the original findings as priors for Bayesian analyses, we found strong support for the correlation between structure-from-motion percept duration and anterior SPL grey matter volume. Correlations between percept duration and other parietal areas as well as occipital GABA, however, were not directly replicated or appeared less strong than previous studies suggested. Inspection of the posterior distributions (current “best guess” based on new data given old data as prior) revealed that several original findings may reflect true relationships although no direct evidence was found in support of them in the current sample. Additionally, we found that multiple regression models based on grey matter volume at 2–3 parietal locations (but not including GABA) were the best predictors of percept duration, explaining approximately 35% of the inter-individual variance. Taken together, our results provide new estimates of correlation strengths, generally increasing confidence in the role of the aSPL while decreasing confidence in some of the other relationships.

Original languageEnglish
JournalCortex
Volume83
Pages (from-to)292-305
Number of pages14
ISSN0010-9452
DOIs
Publication statusPublished - 2016

Keywords

  • Bistable perception
  • Gamma aminobutyric acid (GABA)
  • Grey matter volume
  • Magnetic resonance spectroscopy
  • Structure-from-motion

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