Impairments of motor function among children with a familial risk of schizophrenia or bipolar disorder at 7 years old in Denmark: an observational cohort study

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  • Birgitte Klee Burton, Child and Adolescent Mental Health Centre, Mental Health Services, Capital Region, Research Unit, Copenhagen University Hospital, Copenhagen, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
  • ,
  • Anne A. E. Thorup, Child and Adolescent Mental Health Centre, Mental Health Services, Capital Region, Research Unit, Copenhagen University Hospital, Copenhagen, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
  • ,
  • Jens Richardt Jepsen, Child and Adolescent Mental Health Centre, Mental Health Services, Capital Region, Research Unit, Copenhagen University Hospital, Copenhagen, Denmark, Centre for Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Psychiatric Hospital Centre Glostrup, Denmark, Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Psychiatric Hospital Centre Glostrup, Denmark, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
  • ,
  • Gry Poulsen, Mental Health Centre Copenhagen, Copenhagen University Hospital, Mental Health Services Capital Region, Hellerup, Denmark, Section of Biostatistics, Department of Public Health, University of Copenhagen, Denmark, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
  • ,
  • Ditte Ellersgaard, Mental Health Centre Copenhagen, Copenhagen University Hospital, Mental Health Services Capital Region, Hellerup, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
  • ,
  • Katrine S. Spang, Child and Adolescent Mental Health Centre, Mental Health Services Capital Region, Research Unit, Copenhagen University Hospital, Copenhagen, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
  • ,
  • Camilla Jerlang Christiani, Mental Health Centre Copenhagen, Copenhagen University Hospital, Mental Health Services Capital Region, Hellerup, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
  • ,
  • Nicoline Hemager, Mental Health Centre Copenhagen, Copenhagen University Hospital, Mental Health Services Capital Region, Hellerup, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
  • ,
  • Ditte Gantriis
  • Aja Neergaard Greve
  • Ole Mors
  • Merete Nordentoft, Mental Health Centre Copenhagen, Copenhagen University Hospital, Mental Health Services Capital Region, Hellerup, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
  • ,
  • Kerstin Jessica Plessen, Child and Adolescent Mental Health Centre, Mental Health Services, Capital Region, Research Unit, Copenhagen University Hospital, Copenhagen, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark

Background Owing to the genetic overlap between schizophrenia and bipolar disorder, we aimed to assess domain-specific motor aberrations and disorder specificity among 7-year-old children with a familial risk of schizophrenia or bipolar disorder by comparing children in familial risk groups with each other and with children not in these risk groups.

Methods In the Danish High Risk and Resilience Study, we established a cohort of 7-year-old children with no, one, or two parents with schizophrenia or bipolar disorder in Denmark between Jan 1, 2013, and Jan 31, 2016. We matched children of parents diagnosed with schizophrenia to children of parents without schizophrenia on the basis of their home address, age, and sex. Even though we did not match children of parents with bipolar disorder directly to controls because of resource constraints, we only recruited children into the three groups who did not differ in terms of age, sex, and urbanicity. We investigated motor function in children using the Movement Assessment Battery for Children-Second Edition. Motor function raters were masked to participants' clinical risk status during assessments. We assessed the effects of familial risk group in a mixed-model analysis with repeated measures with an unstructured variance component matrix.

Findings We studied 514 children (198 [39%] children of parents with schizophrenia, 119 [23%] of parents with bipolar disorder, and 197 [38%] of parents without schizophrenia or bipolar disorder). Children of parents with schizophrenia showed impaired motor performance compared with those of parents without in the subdomains of manual dexterity (mean difference -1.42 [95% CI -2.08 to -0.77]; p

Interpretation Motor abnormalities in children with a familial risk of schizophrenia are specific at 7 years of age with respect to fine motor function and balance, but non-specific with respect to familial risk of bipolar disorder. Clinicians should be aware of motor symptoms and refer children with definite motor problems (below the fifth percentile) to a child physiotherapist.

Original languageEnglish
JournalThe Lancet Psychiatry
Volume4
Issue5
Pages (from-to)400-408
Number of pages9
ISSN2215-0374
DOIs
Publication statusPublished - May 2017

    Research areas

  • MENTAL-DISORDERS, BIRTH COHORT, CHILDHOOD, PARENTS, PSYCHOPATHOLOGY, ENDOPHENOTYPE, DYSFUNCTION, POPULATION, DISABILITY, PSYCHOSES

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