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Impaired cerebral microcirculation in isolated REM sleep behaviour disorder

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Impaired cerebral microcirculation in isolated REM sleep behaviour disorder. / Eskildsen, Simon F; Iranzo, Alex; Stokholm, Morten G; Stær, Kristian; Østergaard, Karen; Serradell, Mónica; Otto, Marit; Svendsen, Kristina B; Garrido, Alicia; Vilas, Dolores; Borghammer, Per; Santamaria, Joan; Møller, Arne; Gaig, Carles; Brooks, David J; Tolosa, Eduardo; Østergaard, Leif; Pavese, Nicola.

In: Brain : a journal of neurology, 20.04.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Eskildsen, SF, Iranzo, A, Stokholm, MG, Stær, K, Østergaard, K, Serradell, M, Otto, M, Svendsen, KB, Garrido, A, Vilas, D, Borghammer, P, Santamaria, J, Møller, A, Gaig, C, Brooks, DJ, Tolosa, E, Østergaard, L & Pavese, N 2021, 'Impaired cerebral microcirculation in isolated REM sleep behaviour disorder', Brain : a journal of neurology. https://doi.org/10.1093/brain/awab054

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Author

Eskildsen, Simon F ; Iranzo, Alex ; Stokholm, Morten G ; Stær, Kristian ; Østergaard, Karen ; Serradell, Mónica ; Otto, Marit ; Svendsen, Kristina B ; Garrido, Alicia ; Vilas, Dolores ; Borghammer, Per ; Santamaria, Joan ; Møller, Arne ; Gaig, Carles ; Brooks, David J ; Tolosa, Eduardo ; Østergaard, Leif ; Pavese, Nicola. / Impaired cerebral microcirculation in isolated REM sleep behaviour disorder. In: Brain : a journal of neurology. 2021.

Bibtex

@article{fc55068cd3f9466ab6cee80a1bea5f40,
title = "Impaired cerebral microcirculation in isolated REM sleep behaviour disorder",
abstract = "During the prodromal period of Parkinson's disease and other α-synucleinopathy-related parkinsonisms, neurodegeneration is thought to progressively affect deep brain nuclei, such as the locus coeruleus, caudal raphe nucleus, substantia nigra, and the forebrain nucleus basalis of Meynert. Besides their involvement in the regulation of mood, sleep, behaviour, and memory functions, these nuclei also innervate parenchymal arterioles and capillaries throughout the cortex, possibly to ensure that oxygen supplies are adjusted according to the needs of neural activity. The aim of this study was to examine whether patients with isolated REM sleep behaviour disorder, a parasomnia considered to be a prodromal phenotype of α-synucleinopathies, reveal microvascular flow disturbances consistent with disrupted central blood flow control. We applied dynamic susceptibility contrast MRI to characterize the microscopic distribution of cerebral blood flow in the cortex of 20 polysomnographic-confirmed patients with isolated REM sleep behaviour disorder (17 males, age range: 54-77 years) and 25 healthy matched controls (25 males, age range: 58-76 years). Patients and controls were cognitively tested by Montreal Cognitive Assessment and Mini Mental State Examination. Results revealed profound hypoperfusion and microvascular flow disturbances throughout the cortex in patients compared to controls. In patients, the microvascular flow disturbances were seen in cortical areas associated with language comprehension, visual processing and recognition and were associated with impaired cognitive performance. We conclude that cortical blood flow abnormalities, possibly related to impaired neurogenic control, are present in patients with isolated REM sleep behaviour disorder and associated with cognitive dysfunction. We hypothesize that pharmacological restoration of perivascular neurotransmitter levels could help maintain cognitive function in patients with this prodromal phenotype of parkinsonism.",
author = "Eskildsen, {Simon F} and Alex Iranzo and Stokholm, {Morten G} and Kristian St{\ae}r and Karen {\O}stergaard and M{\'o}nica Serradell and Marit Otto and Svendsen, {Kristina B} and Alicia Garrido and Dolores Vilas and Per Borghammer and Joan Santamaria and Arne M{\o}ller and Carles Gaig and Brooks, {David J} and Eduardo Tolosa and Leif {\O}stergaard and Nicola Pavese",
note = "{\textcopyright} The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.com.",
year = "2021",
month = apr,
day = "20",
doi = "10.1093/brain/awab054",
language = "English",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Impaired cerebral microcirculation in isolated REM sleep behaviour disorder

AU - Eskildsen, Simon F

AU - Iranzo, Alex

AU - Stokholm, Morten G

AU - Stær, Kristian

AU - Østergaard, Karen

AU - Serradell, Mónica

AU - Otto, Marit

AU - Svendsen, Kristina B

AU - Garrido, Alicia

AU - Vilas, Dolores

AU - Borghammer, Per

AU - Santamaria, Joan

AU - Møller, Arne

AU - Gaig, Carles

AU - Brooks, David J

AU - Tolosa, Eduardo

AU - Østergaard, Leif

AU - Pavese, Nicola

N1 - © The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2021/4/20

Y1 - 2021/4/20

N2 - During the prodromal period of Parkinson's disease and other α-synucleinopathy-related parkinsonisms, neurodegeneration is thought to progressively affect deep brain nuclei, such as the locus coeruleus, caudal raphe nucleus, substantia nigra, and the forebrain nucleus basalis of Meynert. Besides their involvement in the regulation of mood, sleep, behaviour, and memory functions, these nuclei also innervate parenchymal arterioles and capillaries throughout the cortex, possibly to ensure that oxygen supplies are adjusted according to the needs of neural activity. The aim of this study was to examine whether patients with isolated REM sleep behaviour disorder, a parasomnia considered to be a prodromal phenotype of α-synucleinopathies, reveal microvascular flow disturbances consistent with disrupted central blood flow control. We applied dynamic susceptibility contrast MRI to characterize the microscopic distribution of cerebral blood flow in the cortex of 20 polysomnographic-confirmed patients with isolated REM sleep behaviour disorder (17 males, age range: 54-77 years) and 25 healthy matched controls (25 males, age range: 58-76 years). Patients and controls were cognitively tested by Montreal Cognitive Assessment and Mini Mental State Examination. Results revealed profound hypoperfusion and microvascular flow disturbances throughout the cortex in patients compared to controls. In patients, the microvascular flow disturbances were seen in cortical areas associated with language comprehension, visual processing and recognition and were associated with impaired cognitive performance. We conclude that cortical blood flow abnormalities, possibly related to impaired neurogenic control, are present in patients with isolated REM sleep behaviour disorder and associated with cognitive dysfunction. We hypothesize that pharmacological restoration of perivascular neurotransmitter levels could help maintain cognitive function in patients with this prodromal phenotype of parkinsonism.

AB - During the prodromal period of Parkinson's disease and other α-synucleinopathy-related parkinsonisms, neurodegeneration is thought to progressively affect deep brain nuclei, such as the locus coeruleus, caudal raphe nucleus, substantia nigra, and the forebrain nucleus basalis of Meynert. Besides their involvement in the regulation of mood, sleep, behaviour, and memory functions, these nuclei also innervate parenchymal arterioles and capillaries throughout the cortex, possibly to ensure that oxygen supplies are adjusted according to the needs of neural activity. The aim of this study was to examine whether patients with isolated REM sleep behaviour disorder, a parasomnia considered to be a prodromal phenotype of α-synucleinopathies, reveal microvascular flow disturbances consistent with disrupted central blood flow control. We applied dynamic susceptibility contrast MRI to characterize the microscopic distribution of cerebral blood flow in the cortex of 20 polysomnographic-confirmed patients with isolated REM sleep behaviour disorder (17 males, age range: 54-77 years) and 25 healthy matched controls (25 males, age range: 58-76 years). Patients and controls were cognitively tested by Montreal Cognitive Assessment and Mini Mental State Examination. Results revealed profound hypoperfusion and microvascular flow disturbances throughout the cortex in patients compared to controls. In patients, the microvascular flow disturbances were seen in cortical areas associated with language comprehension, visual processing and recognition and were associated with impaired cognitive performance. We conclude that cortical blood flow abnormalities, possibly related to impaired neurogenic control, are present in patients with isolated REM sleep behaviour disorder and associated with cognitive dysfunction. We hypothesize that pharmacological restoration of perivascular neurotransmitter levels could help maintain cognitive function in patients with this prodromal phenotype of parkinsonism.

U2 - 10.1093/brain/awab054

DO - 10.1093/brain/awab054

M3 - Journal article

C2 - 33880533

JO - Brain

JF - Brain

SN - 0006-8950

ER -