Impact of the rumen microbiome on milk fatty acid composition of Holstein cattle

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Impact of the rumen microbiome on milk fatty acid composition of Holstein cattle. / Buitenhuis, Bart; Lassen, Jan; Noel, Samantha Joan; Plichta, Damian R; Sørensen, Peter; Difford, Gareth F; Poulsen, Nina A.

In: Genetics Selection Evolution, Vol. 51, No. 1, 23, 2019.

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@article{fe2e59a908b14026822103abf878eba4,
title = "Impact of the rumen microbiome on milk fatty acid composition of Holstein cattle",
abstract = "BACKGROUND: Fatty acids (FA) in bovine milk derive through body mobilization, de novo synthesis or from the feed via the blood stream. To be able to digest feedstuff, the cow depends on its rumen microbiome. The relative abundance of the microbes has been shown to differ between cows. To date, there is little information on the impact of the microbiome on the formation of specific milk FA. Therefore, in this study, our aim was to investigate the impact of the rumen bacterial microbiome on milk FA composition. Furthermore, we evaluated the predictive value of the rumen microbiome and the host genetics on the composition of individual FA in milk.RESULTS: Our results show that the proportion of variance explained by the rumen bacteria composition (termed microbiability or [Formula: see text]) was generally smaller than that of the genetic component (heritability), and that rumen bacteria influenced most C15:0, C17:0, C18:2 n-6, C18:3 n-3 and CLA cis-9, trans-11 with estimated [Formula: see text] ranging from 0.26 to 0.42. For C6:0, C8:0, C10:0, C12:0, C16:0, C16:1 cis-9 and C18:1 cis-9, the variance explained by the rumen bacteria component was close to 0. In general, both the rumen microbiome and the host genetics had little value for predicting FA phenotype. Compared to genetic information only, adding rumen bacteria information resulted in a significant improvement of the predictive value for C15:0 from 0.22 to 0.38 (P = 9.50e-07) and C18:3 n-3 from 0 to 0.29 (P = 8.81e-18).CONCLUSIONS: The rumen microbiome has a pronounced influence on the content of odd chain FA and polyunsaturated C18 FA, and to a lesser extent, on the content of the short- and medium-chain FA in the milk of Holstein cattle. The accuracy of prediction of FA phenotypes in milk based on information from either the animal's genotypes or rumen bacteria composition was very low.",
keywords = "Animals, Cattle/metabolism, Fatty Acids/metabolism, Microbiota, Milk/metabolism, Rumen/microbiology, DANISH HOLSTEIN, STAGE, JERSEY, HERD, PREDICTION, ODD-CHAIN, GENETIC-PARAMETERS, TRAITS, EFFICIENT",
author = "Bart Buitenhuis and Jan Lassen and Noel, {Samantha Joan} and Plichta, {Damian R} and Peter S{\o}rensen and Difford, {Gareth F} and Poulsen, {Nina A}",
year = "2019",
doi = "10.1186/s12711-019-0464-8",
language = "English",
volume = "51",
journal = "Genetics Selection Evolution",
issn = "0999-193X",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Impact of the rumen microbiome on milk fatty acid composition of Holstein cattle

AU - Buitenhuis, Bart

AU - Lassen, Jan

AU - Noel, Samantha Joan

AU - Plichta, Damian R

AU - Sørensen, Peter

AU - Difford, Gareth F

AU - Poulsen, Nina A

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Fatty acids (FA) in bovine milk derive through body mobilization, de novo synthesis or from the feed via the blood stream. To be able to digest feedstuff, the cow depends on its rumen microbiome. The relative abundance of the microbes has been shown to differ between cows. To date, there is little information on the impact of the microbiome on the formation of specific milk FA. Therefore, in this study, our aim was to investigate the impact of the rumen bacterial microbiome on milk FA composition. Furthermore, we evaluated the predictive value of the rumen microbiome and the host genetics on the composition of individual FA in milk.RESULTS: Our results show that the proportion of variance explained by the rumen bacteria composition (termed microbiability or [Formula: see text]) was generally smaller than that of the genetic component (heritability), and that rumen bacteria influenced most C15:0, C17:0, C18:2 n-6, C18:3 n-3 and CLA cis-9, trans-11 with estimated [Formula: see text] ranging from 0.26 to 0.42. For C6:0, C8:0, C10:0, C12:0, C16:0, C16:1 cis-9 and C18:1 cis-9, the variance explained by the rumen bacteria component was close to 0. In general, both the rumen microbiome and the host genetics had little value for predicting FA phenotype. Compared to genetic information only, adding rumen bacteria information resulted in a significant improvement of the predictive value for C15:0 from 0.22 to 0.38 (P = 9.50e-07) and C18:3 n-3 from 0 to 0.29 (P = 8.81e-18).CONCLUSIONS: The rumen microbiome has a pronounced influence on the content of odd chain FA and polyunsaturated C18 FA, and to a lesser extent, on the content of the short- and medium-chain FA in the milk of Holstein cattle. The accuracy of prediction of FA phenotypes in milk based on information from either the animal's genotypes or rumen bacteria composition was very low.

AB - BACKGROUND: Fatty acids (FA) in bovine milk derive through body mobilization, de novo synthesis or from the feed via the blood stream. To be able to digest feedstuff, the cow depends on its rumen microbiome. The relative abundance of the microbes has been shown to differ between cows. To date, there is little information on the impact of the microbiome on the formation of specific milk FA. Therefore, in this study, our aim was to investigate the impact of the rumen bacterial microbiome on milk FA composition. Furthermore, we evaluated the predictive value of the rumen microbiome and the host genetics on the composition of individual FA in milk.RESULTS: Our results show that the proportion of variance explained by the rumen bacteria composition (termed microbiability or [Formula: see text]) was generally smaller than that of the genetic component (heritability), and that rumen bacteria influenced most C15:0, C17:0, C18:2 n-6, C18:3 n-3 and CLA cis-9, trans-11 with estimated [Formula: see text] ranging from 0.26 to 0.42. For C6:0, C8:0, C10:0, C12:0, C16:0, C16:1 cis-9 and C18:1 cis-9, the variance explained by the rumen bacteria component was close to 0. In general, both the rumen microbiome and the host genetics had little value for predicting FA phenotype. Compared to genetic information only, adding rumen bacteria information resulted in a significant improvement of the predictive value for C15:0 from 0.22 to 0.38 (P = 9.50e-07) and C18:3 n-3 from 0 to 0.29 (P = 8.81e-18).CONCLUSIONS: The rumen microbiome has a pronounced influence on the content of odd chain FA and polyunsaturated C18 FA, and to a lesser extent, on the content of the short- and medium-chain FA in the milk of Holstein cattle. The accuracy of prediction of FA phenotypes in milk based on information from either the animal's genotypes or rumen bacteria composition was very low.

KW - Animals

KW - Cattle/metabolism

KW - Fatty Acids/metabolism

KW - Microbiota

KW - Milk/metabolism

KW - Rumen/microbiology

KW - DANISH HOLSTEIN

KW - STAGE

KW - JERSEY

KW - HERD

KW - PREDICTION

KW - ODD-CHAIN

KW - GENETIC-PARAMETERS

KW - TRAITS

KW - EFFICIENT

UR - http://www.scopus.com/inward/record.url?scp=85066945880&partnerID=8YFLogxK

U2 - 10.1186/s12711-019-0464-8

DO - 10.1186/s12711-019-0464-8

M3 - Journal article

C2 - 31142263

VL - 51

JO - Genetics Selection Evolution

JF - Genetics Selection Evolution

SN - 0999-193X

IS - 1

M1 - 23

ER -