Impact of Dietary Sodium Butyrate and Salinomycin on Performance and Intestinal Microbiota in a Broiler Gut Leakage Model

TY - JOUR

T1 - Impact of Dietary Sodium Butyrate and Salinomycin on Performance and Intestinal Microbiota in a Broiler Gut Leakage Model

AU - Naghizadeh, Mohammad

AU - Klaver, Laura

AU - Schönherz, Anna A.

AU - Rani, Sundas

AU - Dalgaard, Tina Sørensen

AU - Engberg, Ricarda Margarete

PY - 2022/1

Y1 - 2022/1

N2 - Imbalanced microbiota related to intestinal leakage is an emerging health problem in commercial broilers associated with partial loss of gut function and reduction in growth performance. Salinomycin is an ionophore coccidiostat with antibiotic effect, which is used as additive in broiler diets to control enteric diseases and improve performance. Due to the growing concern of the development of bacterial antibiotic resistance, ionophores are expected to be banned, within the EU, as feed additives in the near future. Butyrate with multiple beneficial effects on growth performance and pathogen control in broilers has been introduced as a promising alternative. In this study, the ability of a coated butyrate product to alleviate intestinal imbalance was compared to that of salinomycin after enteric challenge. Compared to butyrate and non-supplemented control, salinomycin increased potentially beneficial Ruminococcaceae and reduced potentially pathogenic Enterobacteriaceae, and counts of Lactobacillus salivarius and Clostridium perfringens. Further, salinomycin improved broiler performance. Dietary inclusion of coated butyrate had only limited effects on the composition of the broiler microbiota. Whether improved growth and feed utilization in the salinomycin-supplemented animals can be explained by suppression of C. perfringens and L. salivarius and enrichment of butyrate- and lactic acid-producing bacteria (Ruminococcaceae and Lactobacillaceae) needs further verification.

AB - Imbalanced microbiota related to intestinal leakage is an emerging health problem in commercial broilers associated with partial loss of gut function and reduction in growth performance. Salinomycin is an ionophore coccidiostat with antibiotic effect, which is used as additive in broiler diets to control enteric diseases and improve performance. Due to the growing concern of the development of bacterial antibiotic resistance, ionophores are expected to be banned, within the EU, as feed additives in the near future. Butyrate with multiple beneficial effects on growth performance and pathogen control in broilers has been introduced as a promising alternative. In this study, the ability of a coated butyrate product to alleviate intestinal imbalance was compared to that of salinomycin after enteric challenge. Compared to butyrate and non-supplemented control, salinomycin increased potentially beneficial Ruminococcaceae and reduced potentially pathogenic Enterobacteriaceae, and counts of Lactobacillus salivarius and Clostridium perfringens. Further, salinomycin improved broiler performance. Dietary inclusion of coated butyrate had only limited effects on the composition of the broiler microbiota. Whether improved growth and feed utilization in the salinomycin-supplemented animals can be explained by suppression of C. perfringens and L. salivarius and enrichment of butyrate- and lactic acid-producing bacteria (Ruminococcaceae and Lactobacillaceae) needs further verification.

KW - gut leakage

KW - dysbacteriosis

KW - 16S rRNA gene

KW - amplicon sequencing

KW - gut health

KW - butyrate

KW - salinomycin

U2 - 10.3390/ani12010111

DO - 10.3390/ani12010111

M3 - Journal article

C2 - 35011218

SN - 2076-2615

VL - 12

JO - Animals

JF - Animals

IS - 1

M1 - 111

ER -