Imaging of the parkinsonian brain in relation to restorative therapy

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DOI

  • A. Jon Stoessl, The University of British Columbia
  • ,
  • Vesna Sossi, The University of British Columbia
  • ,
  • David J. Brooks

Positron emission tomography can be extremely useful for the in vivo assessment of graft integrity and function following transplantation for Parkinson's disease. Broadly speaking, PET can be used to assess (i) neurochemical function and integrity and (ii) restoration of functional circuitry. As discussed below, it should be noted that while one might not expect the latter to take place in the absence of the former, the two processes are not entirely correlated. Thus, while fluorodopa PET might improve within a few months of the transplant procedure, with a relatively early plateau and little further improvement over time, there may be a delay in the restoration of function in the Cortico-Striatal-Thalamo-Cortical (CSTC) circuitry (Piccini et al., 2000).

Original languageEnglish
Title of host publicationRestorative Therapies in Parkinson's Disease
Number of pages12
PublisherSpringer US
Publication year1 Dec 2006
Pages119-130
ISBN (print)038729984X, 9780387299846
DOIs
Publication statusPublished - 1 Dec 2006
Externally publishedYes

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