Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers

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Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectively. Comparisons were made with healthy controls. Five LRRK2-NMCs had subclinical reductions of putaminal 18F-DOPA uptake. Three of them had significantly raised nigral 11C-PK11195 binding bilaterally. These findings indicate that nigrostriatal dysfunction and neuroinflammation occur in LRRK2-NMCs. Studies in larger cohorts with appropriate follow-up are needed to elucidate the significance of neuroinflammation in the premotor phase of LRRK2-PD.

Original languageEnglish
Book seriesJournal of Neurology
Volume267
Issue8
Pages (from-to)2296-2300
Number of pages5
ISSN0939-1517
DOIs
Publication statusPublished - Aug 2020

    Research areas

  • Genetics, Parkinson's disease, Clinical neurology, PET, Movement disorders, PATHOLOGY, DISEASE, SYNUCLEINOPATHIES, PENETRANCE, Parkinson’s disease

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