IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

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IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission. / Klinkhammer, Jonas; Schnepf, Daniel; Ye, Liang; Schwaderlapp, Marilena; Gad, Hans Henrik; Hartmann, Rune; Garcin, Dominique; Mahlakõiv, Tanel; Staeheli, Peter.

In: eLife, Vol. 7, e33354, 13.04.2018.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Klinkhammer, J, Schnepf, D, Ye, L, Schwaderlapp, M, Gad, HH, Hartmann, R, Garcin, D, Mahlakõiv, T & Staeheli, P 2018, 'IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission', eLife, vol. 7, e33354. https://doi.org/10.7554/eLife.33354

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Author

Klinkhammer, Jonas ; Schnepf, Daniel ; Ye, Liang ; Schwaderlapp, Marilena ; Gad, Hans Henrik ; Hartmann, Rune ; Garcin, Dominique ; Mahlakõiv, Tanel ; Staeheli, Peter. / IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission. In: eLife. 2018 ; Vol. 7.

Bibtex

@article{b05fb9382ecc4648aae599f008303122,
title = "IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission",
abstract = "Host factors restricting the transmission of respiratory viruses are poorly characterized. We analyzed the contribution of type I and type III interferon (IFN) using a mouse model in which the virus is selectively administered to the upper airways, mimicking a natural respiratory virus infection. Mice lacking functional IFN-λ receptors (Ifnlr1-/-) no longer restricted virus dissemination from the upper airways to the lungs. Ifnlr1-/- mice shed significantly more infectious virus particles via the nostrils and transmitted the virus much more efficiently to na{\"i}ve contacts compared with wild-type mice or mice lacking functional type I IFN receptors. Prophylactic treatment with IFN-α or IFN-λ inhibited initial virus replication in all parts of the respiratory tract, but only IFN-λ conferred long-lasting antiviral protection in the upper airways and blocked virus transmission. Thus, IFN-λ has a decisive and non-redundant function in the upper airways that greatly limits transmission of respiratory viruses to na{\"i}ve contacts.",
author = "Jonas Klinkhammer and Daniel Schnepf and Liang Ye and Marilena Schwaderlapp and Gad, {Hans Henrik} and Rune Hartmann and Dominique Garcin and Tanel Mahlak{\~o}iv and Peter Staeheli",
note = "{\circledC} 2018, Klinkhammer et al.",
year = "2018",
month = "4",
day = "13",
doi = "10.7554/eLife.33354",
language = "English",
volume = "7",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications Ltd.",

}

RIS

TY - JOUR

T1 - IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

AU - Klinkhammer, Jonas

AU - Schnepf, Daniel

AU - Ye, Liang

AU - Schwaderlapp, Marilena

AU - Gad, Hans Henrik

AU - Hartmann, Rune

AU - Garcin, Dominique

AU - Mahlakõiv, Tanel

AU - Staeheli, Peter

N1 - © 2018, Klinkhammer et al.

PY - 2018/4/13

Y1 - 2018/4/13

N2 - Host factors restricting the transmission of respiratory viruses are poorly characterized. We analyzed the contribution of type I and type III interferon (IFN) using a mouse model in which the virus is selectively administered to the upper airways, mimicking a natural respiratory virus infection. Mice lacking functional IFN-λ receptors (Ifnlr1-/-) no longer restricted virus dissemination from the upper airways to the lungs. Ifnlr1-/- mice shed significantly more infectious virus particles via the nostrils and transmitted the virus much more efficiently to naïve contacts compared with wild-type mice or mice lacking functional type I IFN receptors. Prophylactic treatment with IFN-α or IFN-λ inhibited initial virus replication in all parts of the respiratory tract, but only IFN-λ conferred long-lasting antiviral protection in the upper airways and blocked virus transmission. Thus, IFN-λ has a decisive and non-redundant function in the upper airways that greatly limits transmission of respiratory viruses to naïve contacts.

AB - Host factors restricting the transmission of respiratory viruses are poorly characterized. We analyzed the contribution of type I and type III interferon (IFN) using a mouse model in which the virus is selectively administered to the upper airways, mimicking a natural respiratory virus infection. Mice lacking functional IFN-λ receptors (Ifnlr1-/-) no longer restricted virus dissemination from the upper airways to the lungs. Ifnlr1-/- mice shed significantly more infectious virus particles via the nostrils and transmitted the virus much more efficiently to naïve contacts compared with wild-type mice or mice lacking functional type I IFN receptors. Prophylactic treatment with IFN-α or IFN-λ inhibited initial virus replication in all parts of the respiratory tract, but only IFN-λ conferred long-lasting antiviral protection in the upper airways and blocked virus transmission. Thus, IFN-λ has a decisive and non-redundant function in the upper airways that greatly limits transmission of respiratory viruses to naïve contacts.

U2 - 10.7554/eLife.33354

DO - 10.7554/eLife.33354

M3 - Journal article

C2 - 29651984

VL - 7

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e33354

ER -