Idiopathic early ovarian aging: is there a relation with premenopausal accelerated biological aging in young women with diminished response to ART?

Mette Wulf Christensen; David L Keefe; Fang Wang; Christine Søholm Hansen; Isaac J Chamani; Carolyn  Sommer; Mette Nyegaard; Palle D Rohde; Anders Lade Nielsen; Jonas Bybjerg-Grauholm; Ulrik S. Kesmodel; Ulla Breth Knudsen; Kirstine Kirkegaard; Hans Jakob Ingerslev

doi:10.1007/s10815-021-02326-7

Idiopathic early ovarian aging: is there a relation with premenopausal accelerated biological aging in young women with diminished response to ART?

Mette Wulf Christensen, David L Keefe, Fang Wang, Christine Søholm Hansen, Isaac J Chamani, Carolyn Sommer, Mette Nyegaard, Palle D Rohde, Anders Lade Nielsen, Jonas Bybjerg-Grauholm, Ulrik S. Kesmodel, Ulla Breth Knudsen, Kirstine Kirkegaard, Hans Jakob Ingerslev

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

6 Citations (Scopus)

Abstract

PURPOSE: To evaluate whether young women with idiopathic early ovarian aging, as defined by producing fewer oocytes than expected for a given age over multiple in vitro fertilization (IVF) cycles, have changes in telomere length and epigenetic age indicating accelerated biological aging (i.e., increased risk of morbidity and mortality).

METHODS: A prospective cohort study was conducted at two Danish public fertility clinics. A total of 55 young women (≤ 37 years) with at least two IVF cycles with ≤ 5 harvested oocytes despite sufficient stimulation with follicle-stimulating hormone (FSH) were included in the early ovarian aging group. As controls, 52 young women (≤ 37 years) with normal ovarian function, defined by at least eight harvested oocytes, were included. Relative telomere length (rTL) and epigenetic age acceleration (AgeAccel) were measured in white blood cells as markers of premenopausal accelerated biological aging.

RESULTS: rTL was comparable with a mean of 0.46 (± SD 0.12) in the early ovarian aging group and 0.47 (0.14) in the normal ovarian aging group. The AgeAccel of the early ovarian aging group was, insignificantly, 0.5 years older, but this difference disappeared when adjusting for chronological age. Sub-analysis using Anti-Müllerian hormone (AMH) as selection criterion for the two groups did not change the results.

CONCLUSION: We did not find any indications of accelerated aging in whole blood from young women with idiopathic early ovarian aging. Further investigations in a similar cohort of premenopausal women or other tissues are needed to fully elucidate the potential relationship between premenopausal accelerated biological aging and early ovarian aging.

Original language	English
Journal	Journal of Assisted Reproduction and Genetics
Volume	38
Issue	11
Pages (from-to)	3027–3038
Number of pages	12
ISSN	1058-0468
DOIs	https://doi.org/10.1007/s10815-021-02326-7
Publication status	Published - Nov 2021

Keywords

Accelerated aging
Early ovarian aging
Epigenetics
Telomere
Prospective Studies
Follicle Stimulating Hormone/blood
Premenopause
Humans
Ovarian Reserve
Telomere Homeostasis
Case-Control Studies
Pregnancy
Sperm Injections, Intracytoplasmic
DNA Methylation
Fertilization in Vitro
Ovarian Diseases/pathology
Aging
Adult
Female
Aged
Ovarian Follicle/pathology
Anti-Mullerian Hormone/blood
Oocytes/pathology
Pregnancy Rate

Access to Document

10.1007/s10815-021-02326-7

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609087/pdf/10815_2021_Article_2326.pdf

6 Citations
1 Poster

Idiopathic early ovarian ageing: Do biomarkers of ageing indicate premenopausal accelerated biological ageing in young women with diminished response to ART?
Christensen, M. W., Keefe, D. L., Wang, F., Hansen, C., Chamani, I. J., Sommer, C., Nyegaard, M., Rohde, P. D., Nielsen, A. L., Bybjerg-Grauholm, J., kesmodel, U., Breth Knudsen, U., Ingerslev, H. J. & Kirkegaard, K., 26 Jun 2021.
Research output: Contribution to conference › Poster › Research › peer-review

1 Lecture and oral contribution

Low response in female patients and associated health risks
Christensen, M. W. (Lecturer)
1 Oct 2021 → 2 Oct 2021
Activity: Presentations, memberships, employment, ownership and other activities › Lecture and oral contribution

Cite this

Christensen, M. W., Keefe, D. L., Wang, F., Hansen, C. S., Chamani, I. J., Sommer, C., Nyegaard, M., Rohde, P. D., Nielsen, A. L., Bybjerg-Grauholm, J., Kesmodel, U. S., Knudsen, U. B., Kirkegaard, K., & Ingerslev, H. J. (2021). Idiopathic early ovarian aging: is there a relation with premenopausal accelerated biological aging in young women with diminished response to ART? Journal of Assisted Reproduction and Genetics, 38(11), 3027–3038. https://doi.org/10.1007/s10815-021-02326-7

@article{29ea04ede648417c9c1cfc315bdd318d,

title = "Idiopathic early ovarian aging: is there a relation with premenopausal accelerated biological aging in young women with diminished response to ART?",

abstract = "PURPOSE: To evaluate whether young women with idiopathic early ovarian aging, as defined by producing fewer oocytes than expected for a given age over multiple in vitro fertilization (IVF) cycles, have changes in telomere length and epigenetic age indicating accelerated biological aging (i.e., increased risk of morbidity and mortality).METHODS: A prospective cohort study was conducted at two Danish public fertility clinics. A total of 55 young women (≤ 37 years) with at least two IVF cycles with ≤ 5 harvested oocytes despite sufficient stimulation with follicle-stimulating hormone (FSH) were included in the early ovarian aging group. As controls, 52 young women (≤ 37 years) with normal ovarian function, defined by at least eight harvested oocytes, were included. Relative telomere length (rTL) and epigenetic age acceleration (AgeAccel) were measured in white blood cells as markers of premenopausal accelerated biological aging.RESULTS: rTL was comparable with a mean of 0.46 (± SD 0.12) in the early ovarian aging group and 0.47 (0.14) in the normal ovarian aging group. The AgeAccel of the early ovarian aging group was, insignificantly, 0.5 years older, but this difference disappeared when adjusting for chronological age. Sub-analysis using Anti-M{\"u}llerian hormone (AMH) as selection criterion for the two groups did not change the results.CONCLUSION: We did not find any indications of accelerated aging in whole blood from young women with idiopathic early ovarian aging. Further investigations in a similar cohort of premenopausal women or other tissues are needed to fully elucidate the potential relationship between premenopausal accelerated biological aging and early ovarian aging.",

keywords = "Accelerated aging, Early ovarian aging, Epigenetics, Telomere, Prospective Studies, Follicle Stimulating Hormone/blood, Premenopause, Humans, Ovarian Reserve, Telomere Homeostasis, Case-Control Studies, Pregnancy, Sperm Injections, Intracytoplasmic, DNA Methylation, Fertilization in Vitro, Ovarian Diseases/pathology, Aging, Adult, Female, Aged, Ovarian Follicle/pathology, Anti-Mullerian Hormone/blood, Oocytes/pathology, Pregnancy Rate",

author = "Christensen, {Mette Wulf} and Keefe, {David L} and Fang Wang and Hansen, {Christine S{\o}holm} and Chamani, {Isaac J} and Carolyn Sommer and Mette Nyegaard and Rohde, {Palle D} and Nielsen, {Anders Lade} and Jonas Bybjerg-Grauholm and Kesmodel, {Ulrik S.} and Knudsen, {Ulla Breth} and Kirstine Kirkegaard and Ingerslev, {Hans Jakob}",

year = "2021",

month = nov,

doi = "10.1007/s10815-021-02326-7",

language = "English",

volume = "38",

pages = "3027–3038",

journal = "Journal of Assisted Reproduction and Genetics",

issn = "1058-0468",

publisher = "Springer",

number = "11",

}

Christensen, MW, Keefe, DL, Wang, F, Hansen, CS, Chamani, IJ, Sommer, C, Nyegaard, M, Rohde, PD, Nielsen, AL, Bybjerg-Grauholm, J, Kesmodel, US, Knudsen, UB , Kirkegaard, K & Ingerslev, HJ 2021, 'Idiopathic early ovarian aging: is there a relation with premenopausal accelerated biological aging in young women with diminished response to ART?', Journal of Assisted Reproduction and Genetics, vol. 38, no. 11, pp. 3027–3038. https://doi.org/10.1007/s10815-021-02326-7

Idiopathic early ovarian aging: is there a relation with premenopausal accelerated biological aging in young women with diminished response to ART? / Christensen, Mette Wulf; Keefe, David L; Wang, Fang et al.
In: Journal of Assisted Reproduction and Genetics, Vol. 38, No. 11, 11.2021, p. 3027–3038.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Idiopathic early ovarian aging

T2 - is there a relation with premenopausal accelerated biological aging in young women with diminished response to ART?

AU - Christensen, Mette Wulf

AU - Keefe, David L

AU - Wang, Fang

AU - Hansen, Christine Søholm

AU - Chamani, Isaac J

AU - Sommer, Carolyn

AU - Nyegaard, Mette

AU - Rohde, Palle D

AU - Nielsen, Anders Lade

AU - Bybjerg-Grauholm, Jonas

AU - Kesmodel, Ulrik S.

AU - Knudsen, Ulla Breth

AU - Kirkegaard, Kirstine

AU - Ingerslev, Hans Jakob

PY - 2021/11

Y1 - 2021/11

N2 - PURPOSE: To evaluate whether young women with idiopathic early ovarian aging, as defined by producing fewer oocytes than expected for a given age over multiple in vitro fertilization (IVF) cycles, have changes in telomere length and epigenetic age indicating accelerated biological aging (i.e., increased risk of morbidity and mortality).METHODS: A prospective cohort study was conducted at two Danish public fertility clinics. A total of 55 young women (≤ 37 years) with at least two IVF cycles with ≤ 5 harvested oocytes despite sufficient stimulation with follicle-stimulating hormone (FSH) were included in the early ovarian aging group. As controls, 52 young women (≤ 37 years) with normal ovarian function, defined by at least eight harvested oocytes, were included. Relative telomere length (rTL) and epigenetic age acceleration (AgeAccel) were measured in white blood cells as markers of premenopausal accelerated biological aging.RESULTS: rTL was comparable with a mean of 0.46 (± SD 0.12) in the early ovarian aging group and 0.47 (0.14) in the normal ovarian aging group. The AgeAccel of the early ovarian aging group was, insignificantly, 0.5 years older, but this difference disappeared when adjusting for chronological age. Sub-analysis using Anti-Müllerian hormone (AMH) as selection criterion for the two groups did not change the results.CONCLUSION: We did not find any indications of accelerated aging in whole blood from young women with idiopathic early ovarian aging. Further investigations in a similar cohort of premenopausal women or other tissues are needed to fully elucidate the potential relationship between premenopausal accelerated biological aging and early ovarian aging.

AB - PURPOSE: To evaluate whether young women with idiopathic early ovarian aging, as defined by producing fewer oocytes than expected for a given age over multiple in vitro fertilization (IVF) cycles, have changes in telomere length and epigenetic age indicating accelerated biological aging (i.e., increased risk of morbidity and mortality).METHODS: A prospective cohort study was conducted at two Danish public fertility clinics. A total of 55 young women (≤ 37 years) with at least two IVF cycles with ≤ 5 harvested oocytes despite sufficient stimulation with follicle-stimulating hormone (FSH) were included in the early ovarian aging group. As controls, 52 young women (≤ 37 years) with normal ovarian function, defined by at least eight harvested oocytes, were included. Relative telomere length (rTL) and epigenetic age acceleration (AgeAccel) were measured in white blood cells as markers of premenopausal accelerated biological aging.RESULTS: rTL was comparable with a mean of 0.46 (± SD 0.12) in the early ovarian aging group and 0.47 (0.14) in the normal ovarian aging group. The AgeAccel of the early ovarian aging group was, insignificantly, 0.5 years older, but this difference disappeared when adjusting for chronological age. Sub-analysis using Anti-Müllerian hormone (AMH) as selection criterion for the two groups did not change the results.CONCLUSION: We did not find any indications of accelerated aging in whole blood from young women with idiopathic early ovarian aging. Further investigations in a similar cohort of premenopausal women or other tissues are needed to fully elucidate the potential relationship between premenopausal accelerated biological aging and early ovarian aging.

KW - Accelerated aging

KW - Early ovarian aging

KW - Epigenetics

KW - Telomere

KW - Prospective Studies

KW - Follicle Stimulating Hormone/blood

KW - Premenopause

KW - Humans

KW - Ovarian Reserve

KW - Telomere Homeostasis

KW - Case-Control Studies

KW - Pregnancy

KW - Sperm Injections, Intracytoplasmic

KW - DNA Methylation

KW - Fertilization in Vitro

KW - Ovarian Diseases/pathology

KW - Aging

KW - Adult

KW - Female

KW - Aged

KW - Ovarian Follicle/pathology

KW - Anti-Mullerian Hormone/blood

KW - Oocytes/pathology

KW - Pregnancy Rate

U2 - 10.1007/s10815-021-02326-7

DO - 10.1007/s10815-021-02326-7

M3 - Journal article

C2 - 34599460

SN - 1058-0468

VL - 38

SP - 3027

EP - 3038

JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

IS - 11

ER -

Idiopathic early ovarian aging: is there a relation with premenopausal accelerated biological aging in young women with diminished response to ART?

Abstract

Keywords

Access to Document

Fingerprint

Research output

Idiopathic early ovarian ageing: Do biomarkers of ageing indicate premenopausal accelerated biological ageing in young women with diminished response to ART?

Activities

Low response in female patients and associated health risks

Cite this