Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography

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DOI

  • Yong Ming Wang, CAS - Institute of Psychology, Sino-Danish College, University of Chinese Academy of Sciences, Sino-Danish Center for Education and Research
  • ,
  • Zhuo Ya Yang, CAS - Institute of Psychology, University of Chinese Academy of Sciences
  • ,
  • Xin Lu Cai, CAS - Institute of Psychology, University of Chinese Academy of Sciences, Sino-Danish Center for Education and Research
  • ,
  • Han Yu Zhou, CAS - Institute of Psychology, University of Chinese Academy of Sciences
  • ,
  • Rui Ting Zhang, CAS - Institute of Psychology, University of Chinese Academy of Sciences
  • ,
  • Han Xue Yang, CAS - Institute of Psychology, University of Chinese Academy of Sciences
  • ,
  • Yun Si Liang, CAS - Institute of Psychology, University of Chinese Academy of Sciences, Sino-Danish Center for Education and Research
  • ,
  • Xiong Zhao Zhu, Central South University
  • ,
  • Kristoffer Hougaard Madsen, Sino-Danish Center for Education and Research, Copenhagen University Hospital Hvidovre, Technical University of Denmark
  • ,
  • Thomas Alrik Sørensen
  • Arne Møller
  • Zhen Wang, Shanghai Jiao Tong University
  • ,
  • Eric F.C. Cheung, Castle Peak Hospital Hong Kong
  • ,
  • Raymond C.K. Chan, CAS - Institute of Psychology, University of Chinese Academy of Sciences, Sino-Danish Center for Education and Research

A phenomenon in schizophrenia patients that deserves attention is the high comorbidity rate with obsessive-compulsive disorder (OCD). Little is known about the neurobiological basis of schizo-obsessive comorbidity (SOC). We aimed to investigate whether specific changes in white matter exist in patients with SOC and the relationship between such abnormalities and clinical parameters. Twenty-eight patients with SOC, 28 schizophrenia patients, 30 OCD patients, and 30 demographically matched healthy controls were recruited. Using Tract-based Spatial Statistics and Probabilistic Tractography, we examined the pattern of white matter abnormalities in these participants. We also used ANOVA and Support Vector Classification of various white matter indices and structural connection probability to further examine white matter changes among the 4 groups. We found that patients with SOC had decreased fractional anisotropy (FA) and increased radial diffusivity in the right sagittal stratum and the left crescent of the fornix/stria terminalis compared with healthy controls. We also found changed connection probability in the Default Mode Network, the Subcortical Network, the Attention Network, the Task Control Network, the Visual Network, the Somatosensory Network, and the cerebellum in the SOC group compared with the other 3 groups. The classification results further revealed that FA features could differentiate the SOC group from the other 3 groups with an accuracy of .78. These findings highlight the specific white matter abnormalities found in patients with SOC.

Original languageEnglish
JournalSchizophrenia Bulletin
Volume46
Issue2
Pages (from-to)442-453
Number of pages12
ISSN0586-7614
DOIs
Publication statusPublished - Mar 2020

    Research areas

  • diffusion tensor imaging, obsessive-compulsive disorder, schizo-obsessive comorbidity, schizophrenia, support vector classification

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