Identifying hotspots of cardiometabolic outcomes based on a Bayesian approach: The example of Chile

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  • Gloria A Aguayo, Luxembourg Institute of Health, Luxembourg
  • Anna Schritz, Luxembourg Institute of Health, Luxembourg
  • Maria Ruiz-Castell, Luxembourg Institute of Health, Luxembourg
  • Luis Villarroel, Pontificia Universidad Catolica de Chile, Chile
  • Gonzalo Valdivia, Pontificia Universidad Catolica de Chile, Chile
  • Guy Fagherazzi, Luxembourg Institute of Health, Luxembourg
  • Daniel R Witte
  • Andrew Lawson, Medical University of South Carolina, United States

BACKGROUND: There is a need to identify priority zones for cardiometabolic prevention. Disease mapping in countries with high heterogeneity in the geographic distribution of the population is challenging. Our goal was to map the cardiometabolic health and identify hotspots of disease using data from a national health survey.

METHODS: Using Chile as a case study, we applied a Bayesian hierarchical modelling. We performed a cross-sectional analysis of the 2009-2010 Chilean Health Survey. Outcomes were diabetes (all types), obesity, hypertension, and high LDL cholesterol. To estimate prevalence, we used individual and aggregated data by province. We identified hotspots defined as prevalence in provinces significantly greater than the national prevalence. Models were adjusted for age, sex, their interaction, and sampling weight. We imputed missing data. We applied a joint outcome modelling approach to capture the association between the four outcomes.

RESULTS: We analysed data from 4,780 participants (mean age (SD) 46 (19) years; 60% women). The national prevalence (percentage (95% credible intervals) for diabetes, obesity, hypertension and high LDL cholesterol were 10.9 (4.5, 19.2), 30.0 (17.7, 45.3), 36.4 (16.4, 57.6), and 13.7 (3.4, 32.2) respectively. Prevalence of diabetes was lower in the far south. Prevalence of obesity and hypertension increased from north to far south. Prevalence of high LDL cholesterol was higher in the north and south. A hotspot for diabetes was located in the centre. Hotspots for obesity were mainly situated in the south and far south, for hypertension in the centre, south and far south and for high LDL cholesterol in the far south.

CONCLUSIONS: The distribution of cardiometabolic risk factors in Chile has a characteristic pattern with a general trend to a north-south gradient. Our approach is reproducible and demonstrates that the Bayesian approach enables the accurate identification of hotspots and mapping of disease, allowing the identification of areas for cardiometabolic prevention.

Original languageEnglish
Article numbere0235009
JournalPLOS ONE
Volume15
Issue6
Number of pages16
ISSN1932-6203
DOIs
Publication statusPublished - Jun 2020

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