Identification of endogenous retroviral reading frames in the human genome

TY - JOUR

T1 - Identification of endogenous retroviral reading frames in the human genome

AU - Villesen, Palle

AU - Aagaard, Lars

AU - Wiuf, Carsten

AU - Pedersen, Finn Skou

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Human endogenous retroviruses (HERVs) comprise a large class of repetitive retroelements. Most HERVs are ancient and invaded our genome at least 25 million years ago, except for the evolutionary young HERV-K group. The far majority of the encoded genes are degenerate due to mutational decay and only a few non-HERV-K loci are known to retain intact reading frames. Additional intact HERV genes may exist, since retroviral reading frames have not been systematically annotated on a genome-wide scale.

AB - Human endogenous retroviruses (HERVs) comprise a large class of repetitive retroelements. Most HERVs are ancient and invaded our genome at least 25 million years ago, except for the evolutionary young HERV-K group. The far majority of the encoded genes are degenerate due to mutational decay and only a few non-HERV-K loci are known to retain intact reading frames. Additional intact HERV genes may exist, since retroviral reading frames have not been systematically annotated on a genome-wide scale.

KW - Codon

KW - Codon, Terminator

KW - Endogenous Retroviruses

KW - Evolution, Molecular

KW - Expressed Sequence Tags

KW - Gene Products, env

KW - Genome, Human

KW - Humans

KW - Open Reading Frames

KW - Reading Frames

U2 - 10.1186/1742-4690-1-32

DO - 10.1186/1742-4690-1-32

M3 - Journal article

C2 - 15476554

SN - 1742-4690

VL - 1

SP - 1

EP - 13

JO - Retrovirology

JF - Retrovirology

IS - 32

ER -