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Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion

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Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion. / Walther, Raoul; Winther, Anna; Fruergaard, Anne Sofie; Akker, Wouter van den; Sørensen, Lise; Nielsen, Signe Maria; Olesen, Morten Tobias Jarlstad; Dai, Yitao; Jeppesen, Henrik Særkjær; Lamagni, Paolo; Savateev, Aleksandra; Pedersen, Søren L.; Frich, Camilla Kaas; Vigier, Cécile Aude; Lock, Nina; Singh, Mandeep; Bansal, Vipul; Meyer, Rikke Louise; Zelikin, Alexander N.

In: Angewandte Chemie International Edition, Vol. 58, No. 1, 02.01.2019, p. 278-282.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Harvard

Walther, R, Winther, A, Fruergaard, AS, Akker, WVD, Sørensen, L, Nielsen, SM, Olesen, MTJ, Dai, Y, Jeppesen, HS, Lamagni, P, Savateev, A, Pedersen, SL, Frich, CK, Vigier, CA, Lock, N, Singh, M, Bansal, V, Meyer, RL & Zelikin, AN 2019, 'Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion', Angewandte Chemie International Edition, vol. 58, no. 1, pp. 278-282. https://doi.org/10.1002/anie.201812668

APA

Walther, R., Winther, A., Fruergaard, A. S., Akker, W. V. D., Sørensen, L., Nielsen, S. M., Olesen, M. T. J., Dai, Y., Jeppesen, H. S., Lamagni, P., Savateev, A., Pedersen, S. L., Frich, C. K., Vigier, C. A., Lock, N., Singh, M., Bansal, V., Meyer, R. L., & Zelikin, A. N. (2019). Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion. Angewandte Chemie International Edition, 58(1), 278-282. https://doi.org/10.1002/anie.201812668

CBE

Walther R, Winther A, Fruergaard AS, Akker WVD, Sørensen L, Nielsen SM, Olesen MTJ, Dai Y, Jeppesen HS, Lamagni P, Savateev A, Pedersen SL, Frich CK, Vigier CA, Lock N, Singh M, Bansal V, Meyer RL, Zelikin AN. 2019. Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion. Angewandte Chemie International Edition. 58(1):278-282. https://doi.org/10.1002/anie.201812668

MLA

Walther, Raoul et al. "Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion". Angewandte Chemie International Edition. 2019, 58(1). 278-282. https://doi.org/10.1002/anie.201812668

Vancouver

Walther R, Winther A, Fruergaard AS, Akker WVD, Sørensen L, Nielsen SM et al. Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion. Angewandte Chemie International Edition. 2019 Jan 2;58(1):278-282. https://doi.org/10.1002/anie.201812668

Author

Walther, Raoul ; Winther, Anna ; Fruergaard, Anne Sofie ; Akker, Wouter van den ; Sørensen, Lise ; Nielsen, Signe Maria ; Olesen, Morten Tobias Jarlstad ; Dai, Yitao ; Jeppesen, Henrik Særkjær ; Lamagni, Paolo ; Savateev, Aleksandra ; Pedersen, Søren L. ; Frich, Camilla Kaas ; Vigier, Cécile Aude ; Lock, Nina ; Singh, Mandeep ; Bansal, Vipul ; Meyer, Rikke Louise ; Zelikin, Alexander N. / Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion. In: Angewandte Chemie International Edition. 2019 ; Vol. 58, No. 1. pp. 278-282.

Bibtex

@article{212299d19b0942bd8c9baa2f9fc85ae3,
title = "Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion",
abstract = "Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of the Origin of Life. However, current nanozymes offer mimicry of a narrow range of mammalian enzymes, near‐exclusively performing redox reactions. We present an unexpected discovery of non‐proteinaceous enzymes based on metals, metal oxides, 1D/2D‐materials, and non‐metallic nanomaterials. The specific novelty of these findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan‐glycosidases. Further novelty lies in the identification of the substrate scope for the lead candidates, specifically in the context of bioconversion of glucuronides, that is, human ",
author = "Raoul Walther and Anna Winther and Fruergaard, {Anne Sofie} and Akker, {Wouter van den} and Lise S{\o}rensen and Nielsen, {Signe Maria} and Olesen, {Morten Tobias Jarlstad} and Yitao Dai and Jeppesen, {Henrik S{\ae}rkj{\ae}r} and Paolo Lamagni and Aleksandra Savateev and Pedersen, {S{\o}ren L.} and Frich, {Camilla Kaas} and Vigier, {C{\'e}cile Aude} and Nina Lock and Mandeep Singh and Vipul Bansal and Meyer, {Rikke Louise} and Zelikin, {Alexander N.}",
year = "2019",
month = jan,
day = "2",
doi = "10.1002/anie.201812668",
language = "English",
volume = "58",
pages = "278--282",
journal = "Angewandte Chemie International Edition",
issn = "1433-7851",
publisher = "Wiley-VCH",
number = "1",

}

RIS

TY - JOUR

T1 - Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion

AU - Walther, Raoul

AU - Winther, Anna

AU - Fruergaard, Anne Sofie

AU - Akker, Wouter van den

AU - Sørensen, Lise

AU - Nielsen, Signe Maria

AU - Olesen, Morten Tobias Jarlstad

AU - Dai, Yitao

AU - Jeppesen, Henrik Særkjær

AU - Lamagni, Paolo

AU - Savateev, Aleksandra

AU - Pedersen, Søren L.

AU - Frich, Camilla Kaas

AU - Vigier, Cécile Aude

AU - Lock, Nina

AU - Singh, Mandeep

AU - Bansal, Vipul

AU - Meyer, Rikke Louise

AU - Zelikin, Alexander N.

PY - 2019/1/2

Y1 - 2019/1/2

N2 - Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of the Origin of Life. However, current nanozymes offer mimicry of a narrow range of mammalian enzymes, near‐exclusively performing redox reactions. We present an unexpected discovery of non‐proteinaceous enzymes based on metals, metal oxides, 1D/2D‐materials, and non‐metallic nanomaterials. The specific novelty of these findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan‐glycosidases. Further novelty lies in the identification of the substrate scope for the lead candidates, specifically in the context of bioconversion of glucuronides, that is, human

AB - Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of the Origin of Life. However, current nanozymes offer mimicry of a narrow range of mammalian enzymes, near‐exclusively performing redox reactions. We present an unexpected discovery of non‐proteinaceous enzymes based on metals, metal oxides, 1D/2D‐materials, and non‐metallic nanomaterials. The specific novelty of these findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan‐glycosidases. Further novelty lies in the identification of the substrate scope for the lead candidates, specifically in the context of bioconversion of glucuronides, that is, human

U2 - 10.1002/anie.201812668

DO - 10.1002/anie.201812668

M3 - Journal article

C2 - 30408323

VL - 58

SP - 278

EP - 282

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 1

ER -