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Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion

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  • Raoul Walther
  • ,
  • Anna Winther
  • Anne Sofie Fruergaard
  • ,
  • Wouter van den Akker
  • ,
  • Lise Sørensen
  • ,
  • Signe Maria Nielsen
  • ,
  • Morten Tobias Jarlstad Olesen
  • Yitao Dai
  • ,
  • Henrik Særkjær Jeppesen
  • ,
  • Paolo Lamagni
  • ,
  • Aleksandra Savateev, Max Planck Institute of Colloids and Interfaces
  • ,
  • Søren L. Pedersen
  • ,
  • Camilla Kaas Frich
  • ,
  • Cécile Aude Vigier
  • ,
  • Nina Lock
  • Mandeep Singh, Royal Melbourne Institute of Technology University
  • ,
  • Vipul Bansal, Royal Melbourne Institute of Technology University
  • ,
  • Rikke Louise Meyer
  • Alexander N. Zelikin
Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of the Origin of Life. However, current nanozymes offer mimicry of a narrow range of mammalian enzymes, near‐exclusively performing redox reactions. We present an unexpected discovery of non‐proteinaceous enzymes based on metals, metal oxides, 1D/2D‐materials, and non‐metallic nanomaterials. The specific novelty of these findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan‐glycosidases. Further novelty lies in the identification of the substrate scope for the lead candidates, specifically in the context of bioconversion of glucuronides, that is, human
Original languageEnglish
JournalAngewandte Chemie International Edition
Pages (from-to)278-282
Number of pages5
Publication statusPublished - 2 Jan 2019

    Research areas

  • enzyme mimicry, enzyme-prodrug therapy, glucuronide, nanozymes, prodrugs

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