Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion

Raoul Walther; Anna Winther; Anne Sofie Fruergaard; Wouter van den Akker; Lise Sørensen; Signe Maria Nielsen; Morten Tobias Jarlstad Olesen; Yitao Dai; Henrik Særkjær Jeppesen; Paolo Lamagni; Aleksandra Savateev; Søren L. Pedersen; Camilla Kaas Frich; Cécile Aude Vigier; Nina Lock; Mandeep Singh; Vipul Bansal; Rikke Louise Meyer; Alexander N. Zelikin

doi:10.1002/anie.201812668

Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion

Raoul Walther, Anna Winther, Anne Sofie Fruergaard, Wouter van den Akker, Lise Sørensen, Signe Maria Nielsen, Morten Tobias Jarlstad Olesen, Yitao Dai, Henrik Særkjær Jeppesen, Paolo Lamagni, Aleksandra Savateev, Søren L. Pedersen, Camilla Kaas Frich, Cécile Aude Vigier, Nina Lock, Mandeep Singh, Vipul Bansal, Rikke Louise Meyer, Alexander N. Zelikin

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

64 Citations (Scopus)

Abstract

Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of the Origin of Life. However, current nanozymes offer mimicry of a narrow range of mammalian enzymes, near-exclusively performing redox reactions. We present an unexpected discovery of non-proteinaceous enzymes based on metals, metal oxides, 1D/2D-materials, and non-metallic nanomaterials. The specific novelty of these findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan-glycosidases. Further novelty lies in the identification of the substrate scope for the lead candidates, specifically in the context of bioconversion of glucuronides, that is, human metabolites and privileged prodrugs in the field of enzyme-prodrug therapies. Lastly, nanozymes are employed for conversion of glucuronide prodrugs into marketed anti-inflammatory and antibacterial agents, as well as “nanozyme prodrug therapy” to mediate antibacterial measures.

Original language	English
Journal	Angewandte Chemie International Edition
Volume	58
Issue	1
Pages (from-to)	278-282
Number of pages	5
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201812668
Publication status	Published - 2 Jan 2019

Keywords

enzyme mimicry
enzyme-prodrug therapy
glucuronide
nanozymes
prodrugs

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Walther, R., Winther, A., Fruergaard, A. S., Akker, W. V. D., Sørensen, L., Nielsen, S. M., Olesen, M. T. J., Dai, Y., Jeppesen, H. S., Lamagni, P., Savateev, A., Pedersen, S. L., Frich, C. K., Vigier, C. A., Lock, N., Singh, M., Bansal, V., Meyer, R. L., & Zelikin, A. N. (2019). Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion. Angewandte Chemie International Edition, 58(1), 278-282. https://doi.org/10.1002/anie.201812668

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title = "Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion",

abstract = "Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of the Origin of Life. However, current nanozymes offer mimicry of a narrow range of mammalian enzymes, near-exclusively performing redox reactions. We present an unexpected discovery of non-proteinaceous enzymes based on metals, metal oxides, 1D/2D-materials, and non-metallic nanomaterials. The specific novelty of these findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan-glycosidases. Further novelty lies in the identification of the substrate scope for the lead candidates, specifically in the context of bioconversion of glucuronides, that is, human metabolites and privileged prodrugs in the field of enzyme-prodrug therapies. Lastly, nanozymes are employed for conversion of glucuronide prodrugs into marketed anti-inflammatory and antibacterial agents, as well as “nanozyme prodrug therapy” to mediate antibacterial measures.",

keywords = "enzyme mimicry, enzyme-prodrug therapy, glucuronide, nanozymes, prodrugs",

author = "Raoul Walther and Anna Winther and Fruergaard, \{Anne Sofie\} and Akker, \{Wouter van den\} and Lise S{\o}rensen and Nielsen, \{Signe Maria\} and Olesen, \{Morten Tobias Jarlstad\} and Yitao Dai and Jeppesen, \{Henrik S{\ae}rkj{\ae}r\} and Paolo Lamagni and Aleksandra Savateev and Pedersen, \{S{\o}ren L.\} and Frich, \{Camilla Kaas\} and Vigier, \{C{\'e}cile Aude\} and Nina Lock and Mandeep Singh and Vipul Bansal and Meyer, \{Rikke Louise\} and Zelikin, \{Alexander N.\}",

year = "2019",

month = jan,

day = "2",

doi = "10.1002/anie.201812668",

language = "English",

volume = "58",

pages = "278--282",

journal = "Angewandte Chemie International Edition",

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Walther, R, Winther, A, Fruergaard, AS, Akker, WVD, Sørensen, L, Nielsen, SM, Olesen, MTJ, Dai, Y, Jeppesen, HS, Lamagni, P, Savateev, A, Pedersen, SL, Frich, CK, Vigier, CA, Lock, N, Singh, M, Bansal, V, Meyer, RL & Zelikin, AN 2019, 'Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion', Angewandte Chemie International Edition, vol. 58, no. 1, pp. 278-282. https://doi.org/10.1002/anie.201812668

Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion. / Walther, Raoul; Winther, Anna; Fruergaard, Anne Sofie et al.
In: Angewandte Chemie International Edition, Vol. 58, No. 1, 02.01.2019, p. 278-282.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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T1 - Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion

AU - Walther, Raoul

AU - Winther, Anna

AU - Fruergaard, Anne Sofie

AU - Akker, Wouter van den

AU - Sørensen, Lise

AU - Nielsen, Signe Maria

AU - Olesen, Morten Tobias Jarlstad

AU - Dai, Yitao

AU - Jeppesen, Henrik Særkjær

AU - Lamagni, Paolo

AU - Savateev, Aleksandra

AU - Pedersen, Søren L.

AU - Frich, Camilla Kaas

AU - Vigier, Cécile Aude

AU - Lock, Nina

AU - Singh, Mandeep

AU - Bansal, Vipul

AU - Meyer, Rikke Louise

AU - Zelikin, Alexander N.

PY - 2019/1/2

Y1 - 2019/1/2

N2 - Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of the Origin of Life. However, current nanozymes offer mimicry of a narrow range of mammalian enzymes, near-exclusively performing redox reactions. We present an unexpected discovery of non-proteinaceous enzymes based on metals, metal oxides, 1D/2D-materials, and non-metallic nanomaterials. The specific novelty of these findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan-glycosidases. Further novelty lies in the identification of the substrate scope for the lead candidates, specifically in the context of bioconversion of glucuronides, that is, human metabolites and privileged prodrugs in the field of enzyme-prodrug therapies. Lastly, nanozymes are employed for conversion of glucuronide prodrugs into marketed anti-inflammatory and antibacterial agents, as well as “nanozyme prodrug therapy” to mediate antibacterial measures.

AB - Nanozymes, nanoparticles that mimic the natural activity of enzymes, are intriguing academically and are important in the context of the Origin of Life. However, current nanozymes offer mimicry of a narrow range of mammalian enzymes, near-exclusively performing redox reactions. We present an unexpected discovery of non-proteinaceous enzymes based on metals, metal oxides, 1D/2D-materials, and non-metallic nanomaterials. The specific novelty of these findings lies in the identification of nanozymes with apparent mimicry of diverse mammalian enzymes, including unique pan-glycosidases. Further novelty lies in the identification of the substrate scope for the lead candidates, specifically in the context of bioconversion of glucuronides, that is, human metabolites and privileged prodrugs in the field of enzyme-prodrug therapies. Lastly, nanozymes are employed for conversion of glucuronide prodrugs into marketed anti-inflammatory and antibacterial agents, as well as “nanozyme prodrug therapy” to mediate antibacterial measures.

KW - enzyme mimicry

KW - enzyme-prodrug therapy

KW - glucuronide

KW - nanozymes

KW - prodrugs

UR - https://www.scopus.com/pages/publications/85057456567

U2 - 10.1002/anie.201812668

DO - 10.1002/anie.201812668

M3 - Journal article

C2 - 30408323

SN - 1433-7851

VL - 58

SP - 278

EP - 282

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 1

ER -

Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion

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Keywords

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