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Flow-mediated vasodilatation: variation and interrelationships with plasma lipids and lipoproteins

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  • Jeppe Grøndahl Rasmussen, Denmark
  • Rikke Bülow Eschen, Denmark
  • Inge Valbak Aardestrup, Denmark
  • Claus Dethlefsen, Denmark
  • Bruce A Griffin, Denmark
  • Erik Berg Schmidt, Denmark
  • Kardiologisk Afdeling, Aalborg Sygehus
  • Kardiovaskulært Forskningscenter, Aalborg Sygehus
OBJECTIVE: Endothelial dysfunction is a critical, prerequisite step in atherosclerosis, and may be evaluated by flow-mediated vasodilatation (FMD). The objective of this study was to examine interrelationships between FMD and plasma lipids and lipoproteins, and to determine the between-operator and within-subject variability associated with this technique. MATERIAL AND METHODS: FMD, plasma lipids and lipoproteins, including small dense LDL (sdLDL), were measured twice in 40 healthy volunteers, 4 weeks apart. Interrelationships between mean FMD responses and plasma lipids and lipoproteins were examined by correlation analysis. FMD measurements were taken by two independent operators, allowing determination of between-operator variability. Within-subject variability was determined by obtaining two measurements, 4 weeks apart, in every subject, and carried out by the same operator. RESULTS: FMD was inversely related to plasma triglycerides (r = -0.47, p = 0.002), total cholesterol/HDL cholesterol (r = -0.35, p = 0.03) and apolipoprotein B (r = -0.36, p = 0.02), but not to other plasma lipids and lipoproteins. When measuring variation in FMD, the following results were found: Between operators (SD = 4.0 FMD%) and within subjects (SD = 2.9 FMD%). CONCLUSIONS: The associations between FMD, plasma triglycerides and apoB provide evidence supporting a role for triglyceride-rich lipoproteins in endothelial dysfunction.
Original languageEnglish
JournalScandinavian Journal of Clinical & Laboratory Investigation
Pages (from-to)156-60
Number of pages4
Publication statusPublished - 2009

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