TY - JOUR
T1 - Hypomagnesemia, insulin secretion and action in patients without diabetes, 1 year after kidney transplantation
AU - Carlsen, Rasmus K.
AU - Åsberg, Anders
AU - Svensson, My
AU - Birkeland, Kåre I.
AU - Jørgensen, Hanne S.
AU - Bressendorff, Iain
AU - Gulseth, Hanne L.
AU - Midtvedt, Karsten
AU - Nordheim, Espen
AU - Jenssen, Trond G.
N1 - Publisher Copyright:
Copyright © 2025 Carlsen, Åsberg, Svensson, Birkeland, Jørgensen, Bressendorff, Gulseth, Midtvedt, Nordheim and Jenssen.
PY - 2025
Y1 - 2025
N2 - Introduction: Hypomagnesemia after kidney transplantation has been reported as a potential risk factor for development of post-transplant diabetes mellitus. Methods: In kidney transplant recipients undergoing an oral glucose tolerance test during one-year surveillance follow-up we estimated insulin sensitivity with the Matsuda index, a modified Stumvoll index, and HOMA-2IR. First and second phase insulin secretion was assessed using the Stumvoll equation. Participants were categorized into tertiles by plasma magnesium levels, (<0.7, 07–0.78,>0.78 mmol/L). Results: We included 208 patients (62% men, median age 51 years). Patients in the lowest compared to the highest magnesium tertile had higher measured GFR (mean 59 vs. 49 mL/min, p = 0.002), tacrolimus trough concentration (mean 6.7 vs. 5.5 μg/L, p < 0.001), and fasting plasma glucose (mean 5.5 vs. 5.3 mmol/L, p = 0.03). There was no significant difference in the Matsuda index between magnesium tertiles, nor in insulin sensitivity assessed by modified Stumvoll index, HOMA-2IR, first or second phase insulin. Results indicate a non-significant trend toward lower disposition index in the lowest vs. highest tertile (p = 0.052). Conclusion: In kidney transplant recipients with lower compared to normal plasma magnesium levels we found a higher fasting plasma glucose but no differences in insulin sensitivity indexes nor dynamic insulin measurements.
AB - Introduction: Hypomagnesemia after kidney transplantation has been reported as a potential risk factor for development of post-transplant diabetes mellitus. Methods: In kidney transplant recipients undergoing an oral glucose tolerance test during one-year surveillance follow-up we estimated insulin sensitivity with the Matsuda index, a modified Stumvoll index, and HOMA-2IR. First and second phase insulin secretion was assessed using the Stumvoll equation. Participants were categorized into tertiles by plasma magnesium levels, (<0.7, 07–0.78,>0.78 mmol/L). Results: We included 208 patients (62% men, median age 51 years). Patients in the lowest compared to the highest magnesium tertile had higher measured GFR (mean 59 vs. 49 mL/min, p = 0.002), tacrolimus trough concentration (mean 6.7 vs. 5.5 μg/L, p < 0.001), and fasting plasma glucose (mean 5.5 vs. 5.3 mmol/L, p = 0.03). There was no significant difference in the Matsuda index between magnesium tertiles, nor in insulin sensitivity assessed by modified Stumvoll index, HOMA-2IR, first or second phase insulin. Results indicate a non-significant trend toward lower disposition index in the lowest vs. highest tertile (p = 0.052). Conclusion: In kidney transplant recipients with lower compared to normal plasma magnesium levels we found a higher fasting plasma glucose but no differences in insulin sensitivity indexes nor dynamic insulin measurements.
KW - hypomagnesemia
KW - insulin action
KW - insulin secretion
KW - kidney transplantation
KW - oral glucose tolerance test
KW - post-transplant diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85216943513&partnerID=8YFLogxK
U2 - 10.3389/fmed.2025.1492871
DO - 10.3389/fmed.2025.1492871
M3 - Journal article
C2 - 39911868
AN - SCOPUS:85216943513
SN - 2296-858X
VL - 12
JO - Frontiers in medicine
JF - Frontiers in medicine
M1 - 1492871
ER -