TY - JOUR
T1 - Hyperpolarized Water for Coronary Artery Angiography and Whole-Heart Myocardial Perfusion Quantification
AU - Zhao, Yupeng
AU - Lerche, Mathilde H
AU - Karlsson, Magnus
AU - Olin, Rie Beck
AU - Søvsø Szocska Hansen, Esben
AU - Aastrup, Malene
AU - Redda, Mohsen
AU - Laustsen, Christoffer
AU - Hansen, Lars G.
AU - Ardenkjær-Larsen, Jan Henrik
PY - 2024/7
Y1 - 2024/7
N2 - Purpose: Water freely diffuses across cell membranes, making it suitable for measuring absolute tissue perfusion. In this study, we introduce an imaging method for conducting coronary artery angiography and quantifying myocardial perfusion across the entire heart using hyperpolarized water. Methods: 1H was hyperpolarized using dissolution dynamic nuclear polarization (dDNP) with UV-generated radicals. Submillimeter resolution coronary artery images were acquired as 2D projections using a spoiled GRE (SPGRE) sequence gated on diastole. Dynamic perfusion images were obtained with a multi-slice SPGRE with diastole gating, covering the entire heart. Perfusion values were analyzed through histograms, and the most frequent estimated perfusion value (the mode of the distribution), was compared with the average values for 15O water PET from the literature. Results: A liquid state polarization of 10% at the time of the injection and a 30 s T1 in D2O TRIS buffer were measured. Both coronary artery and dynamic perfusion images exhibited good quality. The main and small coronary artery branches were well resolved. The most frequent estimated perfusion value is around 0.6 mL/g/min, which is lower than the average values obtained from the literature for 15O-water PET (around 1.1 and 1.5 mL/g/min). Conclusions: The study successfully demonstrated the feasibility of achieving high-resolution, motion-free coronary artery angiography and 3D whole-heart quantitative myocardial perfusion using hyperpolarized water.
AB - Purpose: Water freely diffuses across cell membranes, making it suitable for measuring absolute tissue perfusion. In this study, we introduce an imaging method for conducting coronary artery angiography and quantifying myocardial perfusion across the entire heart using hyperpolarized water. Methods: 1H was hyperpolarized using dissolution dynamic nuclear polarization (dDNP) with UV-generated radicals. Submillimeter resolution coronary artery images were acquired as 2D projections using a spoiled GRE (SPGRE) sequence gated on diastole. Dynamic perfusion images were obtained with a multi-slice SPGRE with diastole gating, covering the entire heart. Perfusion values were analyzed through histograms, and the most frequent estimated perfusion value (the mode of the distribution), was compared with the average values for 15O water PET from the literature. Results: A liquid state polarization of 10% at the time of the injection and a 30 s T1 in D2O TRIS buffer were measured. Both coronary artery and dynamic perfusion images exhibited good quality. The main and small coronary artery branches were well resolved. The most frequent estimated perfusion value is around 0.6 mL/g/min, which is lower than the average values obtained from the literature for 15O-water PET (around 1.1 and 1.5 mL/g/min). Conclusions: The study successfully demonstrated the feasibility of achieving high-resolution, motion-free coronary artery angiography and 3D whole-heart quantitative myocardial perfusion using hyperpolarized water.
KW - coronary artery angiography
KW - hyperpolarized MRI
KW - myocardium
KW - perfusion
UR - http://www.scopus.com/inward/record.url?scp=85199594677&partnerID=8YFLogxK
U2 - 10.3390/tomography10070084
DO - 10.3390/tomography10070084
M3 - Journal article
C2 - 39058056
SN - 2379-1381
VL - 10
SP - 1113
EP - 1122
JO - Tomography - A Journal for Imaging Research
JF - Tomography - A Journal for Imaging Research
IS - 7
ER -