Hyperpolarized [1-13C]Pyruvate MRI identifies metabolic differences pertaining to the fasted and fed state in porcine cardiac metabolism

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Standardized large animal models for cardiac hyperpolarized MR metabolic studies are becoming increasingly important as translation into human trials progresses. We employed a porcine (n=17) model of fasting/feeding to study these two states and to examine normal feeding as a standardized model for increasing hyperpolarized [1-13C]Pyruvate signal in the heart. All metabolic ratios were higher in fed animals with no additional variance. This indicates the role of pyruvate uptake to be more important in pigs than in rodents, underlining the need for large animals in metabolic research, and also suggests feeding to be a feasible, standardized model for increasing signal.
Original languageDanish
Publication year2017
Publication statusPublished - 2017
EventISMRM 2017 Annual Meeting & Exhibition, Honolulu, United State - Honolulu, United States
Duration: 22 Apr 201727 Apr 2017


ConferenceISMRM 2017 Annual Meeting & Exhibition, Honolulu, United State
CountryUnited States

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ID: 115604555