Hudbiopsi og kvantitativ sensorisk testning kan bidrage til diagnostik af småfiberpolyneuropati

TY - JOUR

T1 - Hudbiopsi og kvantitativ sensorisk testning kan bidrage til diagnostik af småfiberpolyneuropati

AU - Krøigård, Thomas

AU - Karlsson, Pall

AU - Finnerup, Nanna Brix

AU - Sindrup, Søren Hein

AU - Jensen, Troels Staehelin

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Nerve conduction studies are normal in small fibre neuropathy and special methods such as skin biopsies or quantitative sensory testing are required for diagnosis. In skin biopsies, nerve fibres are stained immunohistochemically and loss of distal nerve endings can be quantified directly. Assessment of thermal detection thresholds is used to evaluate the function of the sensory thermal pathways, but cannot discriminate between central and peripheral lesions. Small fibre neuropathy is often associated with potentially treatable diseases, and treatment of neuropathic pain may be required.

AB - Nerve conduction studies are normal in small fibre neuropathy and special methods such as skin biopsies or quantitative sensory testing are required for diagnosis. In skin biopsies, nerve fibres are stained immunohistochemically and loss of distal nerve endings can be quantified directly. Assessment of thermal detection thresholds is used to evaluate the function of the sensory thermal pathways, but cannot discriminate between central and peripheral lesions. Small fibre neuropathy is often associated with potentially treatable diseases, and treatment of neuropathic pain may be required.

UR - http://www.scopus.com/inward/record.url?scp=85025428133&partnerID=8YFLogxK

M3 - Review

C2 - 27401988

SN - 0041-5782

VL - 178

SP - 1807

EP - 1810

JO - Ugeskrift for Læger

JF - Ugeskrift for Læger

IS - 25

M1 - V02160134

ER -