Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

    Franziska Kundel, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom., Suman De, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom., Patrick Flagmeier, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom., Mathew H Horrocks, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.,
  • Magnus Kjaergaard
  • Sarah L Shammas, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom., Sophie E Jackson, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom., Christopher M Dobson, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom., David Klenerman, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Original languageEnglish
JournalACS chemical biology
Volume13
Issue number3
Pages (from-to)636-646
Number of pages11
ISSN1554-8929
DOIs
Publication statusPublished - 2018

    Research areas

  • ALPHA-SYNUCLEIN, ALZHEIMERS-DISEASE, CHAPERONE, FIBRILS, NEURONAL PC12 CELLS, OLIGOMERS, P301S TAU, PAIRED HELICAL FILAMENT, PROTEIN HOMEOSTASIS, SINGLE-MOLECULE FLUORESCENCE

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ID: 123461438