How Viruses Hijack and Modify the Secretory Transport Pathway

Zubaida Hassan; Nilima Dinesh Kumar; Fulvio Reggiori; Gulfaraz Khan

doi:10.3390/cells10102535

How Viruses Hijack and Modify the Secretory Transport Pathway

Zubaida Hassan, Nilima Dinesh Kumar, Fulvio Reggiori, Gulfaraz Khan

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

20 Citations (Scopus)

Abstract

Eukaryotic cells contain dynamic membrane-bound organelles that are constantly remodeled in response to physiological and environmental cues. Key organelles are the endoplasmic reticulum, the Golgi apparatus and the plasma membrane, which are interconnected by vesicular traffic through the secretory transport route. Numerous viruses, especially enveloped viruses, use and modify compartments of the secretory pathway to promote their replication, assembly and cell egression by hijacking the host cell machinery. In some cases, the subversion mechanism has been uncovered. In this review, we summarize our current understanding of how the secretory pathway is subverted and exploited by viruses belonging to Picornaviridae, Coronaviridae, Flaviviridae, Poxviridae, Parvoviridae and Herpesviridae families.

Original language	English
Article number	2535
Journal	Cells
Volume	10
Issue	10
DOIs	https://doi.org/10.3390/cells10102535
Publication status	Published - 24 Sept 2021
Externally published	Yes

Keywords

Biological Transport/physiology
Cell Membrane/metabolism
Endoplasmic Reticulum/metabolism
Golgi Apparatus/metabolism
Humans
Secretory Pathway/physiology
Viruses/isolation & purification

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10.3390/cells10102535

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title = "How Viruses Hijack and Modify the Secretory Transport Pathway",

abstract = "Eukaryotic cells contain dynamic membrane-bound organelles that are constantly remodeled in response to physiological and environmental cues. Key organelles are the endoplasmic reticulum, the Golgi apparatus and the plasma membrane, which are interconnected by vesicular traffic through the secretory transport route. Numerous viruses, especially enveloped viruses, use and modify compartments of the secretory pathway to promote their replication, assembly and cell egression by hijacking the host cell machinery. In some cases, the subversion mechanism has been uncovered. In this review, we summarize our current understanding of how the secretory pathway is subverted and exploited by viruses belonging to Picornaviridae, Coronaviridae, Flaviviridae, Poxviridae, Parvoviridae and Herpesviridae families.",

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author = "Zubaida Hassan and Kumar, {Nilima Dinesh} and Fulvio Reggiori and Gulfaraz Khan",

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doi = "10.3390/cells10102535",

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T1 - How Viruses Hijack and Modify the Secretory Transport Pathway

AU - Hassan, Zubaida

AU - Kumar, Nilima Dinesh

AU - Reggiori, Fulvio

AU - Khan, Gulfaraz

PY - 2021/9/24

Y1 - 2021/9/24

N2 - Eukaryotic cells contain dynamic membrane-bound organelles that are constantly remodeled in response to physiological and environmental cues. Key organelles are the endoplasmic reticulum, the Golgi apparatus and the plasma membrane, which are interconnected by vesicular traffic through the secretory transport route. Numerous viruses, especially enveloped viruses, use and modify compartments of the secretory pathway to promote their replication, assembly and cell egression by hijacking the host cell machinery. In some cases, the subversion mechanism has been uncovered. In this review, we summarize our current understanding of how the secretory pathway is subverted and exploited by viruses belonging to Picornaviridae, Coronaviridae, Flaviviridae, Poxviridae, Parvoviridae and Herpesviridae families.

AB - Eukaryotic cells contain dynamic membrane-bound organelles that are constantly remodeled in response to physiological and environmental cues. Key organelles are the endoplasmic reticulum, the Golgi apparatus and the plasma membrane, which are interconnected by vesicular traffic through the secretory transport route. Numerous viruses, especially enveloped viruses, use and modify compartments of the secretory pathway to promote their replication, assembly and cell egression by hijacking the host cell machinery. In some cases, the subversion mechanism has been uncovered. In this review, we summarize our current understanding of how the secretory pathway is subverted and exploited by viruses belonging to Picornaviridae, Coronaviridae, Flaviviridae, Poxviridae, Parvoviridae and Herpesviridae families.

KW - Biological Transport/physiology

KW - Cell Membrane/metabolism

KW - Endoplasmic Reticulum/metabolism

KW - Golgi Apparatus/metabolism

KW - Humans

KW - Secretory Pathway/physiology

KW - Viruses/isolation & purification

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U2 - 10.3390/cells10102535

DO - 10.3390/cells10102535

M3 - Review

C2 - 34685515

VL - 10

JO - Cells

JF - Cells

IS - 10

M1 - 2535

ER -

How Viruses Hijack and Modify the Secretory Transport Pathway

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