Hormonal control of the shoot stem-cell niche

Zhong Zhao; Stig U Andersen; Karin Ljung; Karel Dolezal; Andrej Miotk; Sebastian J Schultheiss; Jan U Lohmann

doi:10.1038/nature09126

Hormonal control of the shoot stem-cell niche

Zhong Zhao, Stig U Andersen, Karin Ljung, Karel Dolezal, Andrej Miotk, Sebastian J Schultheiss, Jan U Lohmann

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

The classic phytohormones cytokinin and auxin play essential roles in the maintenance of stem-cell systems embedded in shoot and root meristems, and exhibit complex functional interactions. Here we show that the activity of both hormones directly converges on the promoters of two A-type ARABIDOPSIS RESPONSE REGULATOR (ARR) genes, ARR7 and ARR15, which are negative regulators of cytokinin signalling and have important meristematic functions. Whereas ARR7 and ARR15 expression in the shoot apical meristem (SAM) is induced by cytokinin, auxin has a negative effect, which is, at least in part, mediated by the AUXIN RESPONSE FACTOR5/MONOPTEROS (MP) transcription factor. Our results provide a mechanistic framework for hormonal control of the apical stem-cell niche and demonstrate how root and shoot stem-cell systems differ in their response to phytohormones.

Original language	English
Journal	Nature
Volume	465
Issue	7301
Pages (from-to)	1089-92
Number of pages	3
ISSN	0028-0836
DOIs	https://doi.org/10.1038/nature09126
Publication status	Published - 2010
Externally published	Yes

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title = "Hormonal control of the shoot stem-cell niche",

abstract = "The classic phytohormones cytokinin and auxin play essential roles in the maintenance of stem-cell systems embedded in shoot and root meristems, and exhibit complex functional interactions. Here we show that the activity of both hormones directly converges on the promoters of two A-type ARABIDOPSIS RESPONSE REGULATOR (ARR) genes, ARR7 and ARR15, which are negative regulators of cytokinin signalling and have important meristematic functions. Whereas ARR7 and ARR15 expression in the shoot apical meristem (SAM) is induced by cytokinin, auxin has a negative effect, which is, at least in part, mediated by the AUXIN RESPONSE FACTOR5/MONOPTEROS (MP) transcription factor. Our results provide a mechanistic framework for hormonal control of the apical stem-cell niche and demonstrate how root and shoot stem-cell systems differ in their response to phytohormones.",

author = "Zhong Zhao and Andersen, {Stig U} and Karin Ljung and Karel Dolezal and Andrej Miotk and Schultheiss, {Sebastian J} and Lohmann, {Jan U}",

year = "2010",

doi = "10.1038/nature09126",

language = "English",

volume = "465",

pages = "1089--92",

journal = "Nature",

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T1 - Hormonal control of the shoot stem-cell niche

AU - Zhao, Zhong

AU - Andersen, Stig U

AU - Ljung, Karin

AU - Dolezal, Karel

AU - Miotk, Andrej

AU - Schultheiss, Sebastian J

AU - Lohmann, Jan U

PY - 2010

Y1 - 2010

N2 - The classic phytohormones cytokinin and auxin play essential roles in the maintenance of stem-cell systems embedded in shoot and root meristems, and exhibit complex functional interactions. Here we show that the activity of both hormones directly converges on the promoters of two A-type ARABIDOPSIS RESPONSE REGULATOR (ARR) genes, ARR7 and ARR15, which are negative regulators of cytokinin signalling and have important meristematic functions. Whereas ARR7 and ARR15 expression in the shoot apical meristem (SAM) is induced by cytokinin, auxin has a negative effect, which is, at least in part, mediated by the AUXIN RESPONSE FACTOR5/MONOPTEROS (MP) transcription factor. Our results provide a mechanistic framework for hormonal control of the apical stem-cell niche and demonstrate how root and shoot stem-cell systems differ in their response to phytohormones.

AB - The classic phytohormones cytokinin and auxin play essential roles in the maintenance of stem-cell systems embedded in shoot and root meristems, and exhibit complex functional interactions. Here we show that the activity of both hormones directly converges on the promoters of two A-type ARABIDOPSIS RESPONSE REGULATOR (ARR) genes, ARR7 and ARR15, which are negative regulators of cytokinin signalling and have important meristematic functions. Whereas ARR7 and ARR15 expression in the shoot apical meristem (SAM) is induced by cytokinin, auxin has a negative effect, which is, at least in part, mediated by the AUXIN RESPONSE FACTOR5/MONOPTEROS (MP) transcription factor. Our results provide a mechanistic framework for hormonal control of the apical stem-cell niche and demonstrate how root and shoot stem-cell systems differ in their response to phytohormones.

U2 - 10.1038/nature09126

DO - 10.1038/nature09126

M3 - Journal article

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SN - 0028-0836

VL - 465

SP - 1089

EP - 1092

JO - Nature

JF - Nature

IS - 7301

ER -

Hormonal control of the shoot stem-cell niche

Abstract

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