High-sensitivity troponin T and I in patients suspected of acute myocardial infarction

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Standard

High-sensitivity troponin T and I in patients suspected of acute myocardial infarction. / Kleemeier, Steffan; Abildgaard, Anders; Ladefoged, Søren Andreas et al.

In: Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 82, No. 2, 04.2022, p. 96-103.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Kleemeier, S, Abildgaard, A, Ladefoged, SA, Thorsted Sørensen, J, Stengaard, C & Adelborg, K 2022, 'High-sensitivity troponin T and I in patients suspected of acute myocardial infarction', Scandinavian Journal of Clinical and Laboratory Investigation, vol. 82, no. 2, pp. 96-103. https://doi.org/10.1080/00365513.2022.2033310

APA

CBE

MLA

Kleemeier, Steffan et al. "High-sensitivity troponin T and I in patients suspected of acute myocardial infarction". Scandinavian Journal of Clinical and Laboratory Investigation. 2022, 82(2). 96-103. https://doi.org/10.1080/00365513.2022.2033310

Vancouver

Kleemeier S, Abildgaard A, Ladefoged SA, Thorsted Sørensen J, Stengaard C, Adelborg K. High-sensitivity troponin T and I in patients suspected of acute myocardial infarction. Scandinavian Journal of Clinical and Laboratory Investigation. 2022 Apr;82(2):96-103. doi: 10.1080/00365513.2022.2033310

Author

Kleemeier, Steffan ; Abildgaard, Anders ; Ladefoged, Søren Andreas et al. / High-sensitivity troponin T and I in patients suspected of acute myocardial infarction. In: Scandinavian Journal of Clinical and Laboratory Investigation. 2022 ; Vol. 82, No. 2. pp. 96-103.

Bibtex

@article{d816d1cc21954512a529c4843cccaccd,
title = "High-sensitivity troponin T and I in patients suspected of acute myocardial infarction",
abstract = "Measurement of cardiac troponin (cTn) is the cornerstone in the diagnosis of myocardial infarction (MI). Potential disparities in concentrations of cTn, trajectories and mortality, following initial measurement warrant further investigation. Such data may guide clinicians treating patients suspected of MI. Plasma concentrations of cTnT and cTnI were measured in 503 consecutive patients at Aarhus University Hospital between June 13th and June 27th, 2019. cTnT was measured with the Roche cobas{\textregistered} E602 hs-cTnT assay, while cTnI was measured with the Siemens ADVIA Centaur{\textregistered} XPT hs-cTnI assay. Analytical agreement was determined based on assay-specific 99th percentiles. Medical records were reviewed for adjudication of the MI diagnosis. MI was the final diagnosis in 65 patients (12.9%) and the analytical agreement between cTnT and cTnI assays was 95.2%. For patients diagnosed with MI, cTnI reached higher peak concentrations in shorter time, compared to cTnT. All-cause mortality risk increased with increasing levels of both biomarkers. In this study, the analytical agreement of two cTn assays was high. However, some disparities in troponin trajectories were observed.",
keywords = "acute coronary syndrome, coronary artery disease, diagnosis, high-sensitivity troponin, Myocardial infarction, prognosis",
author = "Steffan Kleemeier and Anders Abildgaard and Ladefoged, {S{\o}ren Andreas} and {Thorsted S{\o}rensen}, Jacob and Carsten Stengaard and Kasper Adelborg",
note = "Publisher Copyright: {\textcopyright} 2022 Medisinsk Fysiologisk Forenings Forlag (MFFF).",
year = "2022",
month = apr,
doi = "10.1080/00365513.2022.2033310",
language = "English",
volume = "82",
pages = "96--103",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation. Supplement",
issn = "0085-591X",
publisher = "Taylor & Francis A B",
number = "2",

}

RIS

TY - JOUR

T1 - High-sensitivity troponin T and I in patients suspected of acute myocardial infarction

AU - Kleemeier, Steffan

AU - Abildgaard, Anders

AU - Ladefoged, Søren Andreas

AU - Thorsted Sørensen, Jacob

AU - Stengaard, Carsten

AU - Adelborg, Kasper

N1 - Publisher Copyright: © 2022 Medisinsk Fysiologisk Forenings Forlag (MFFF).

PY - 2022/4

Y1 - 2022/4

N2 - Measurement of cardiac troponin (cTn) is the cornerstone in the diagnosis of myocardial infarction (MI). Potential disparities in concentrations of cTn, trajectories and mortality, following initial measurement warrant further investigation. Such data may guide clinicians treating patients suspected of MI. Plasma concentrations of cTnT and cTnI were measured in 503 consecutive patients at Aarhus University Hospital between June 13th and June 27th, 2019. cTnT was measured with the Roche cobas® E602 hs-cTnT assay, while cTnI was measured with the Siemens ADVIA Centaur® XPT hs-cTnI assay. Analytical agreement was determined based on assay-specific 99th percentiles. Medical records were reviewed for adjudication of the MI diagnosis. MI was the final diagnosis in 65 patients (12.9%) and the analytical agreement between cTnT and cTnI assays was 95.2%. For patients diagnosed with MI, cTnI reached higher peak concentrations in shorter time, compared to cTnT. All-cause mortality risk increased with increasing levels of both biomarkers. In this study, the analytical agreement of two cTn assays was high. However, some disparities in troponin trajectories were observed.

AB - Measurement of cardiac troponin (cTn) is the cornerstone in the diagnosis of myocardial infarction (MI). Potential disparities in concentrations of cTn, trajectories and mortality, following initial measurement warrant further investigation. Such data may guide clinicians treating patients suspected of MI. Plasma concentrations of cTnT and cTnI were measured in 503 consecutive patients at Aarhus University Hospital between June 13th and June 27th, 2019. cTnT was measured with the Roche cobas® E602 hs-cTnT assay, while cTnI was measured with the Siemens ADVIA Centaur® XPT hs-cTnI assay. Analytical agreement was determined based on assay-specific 99th percentiles. Medical records were reviewed for adjudication of the MI diagnosis. MI was the final diagnosis in 65 patients (12.9%) and the analytical agreement between cTnT and cTnI assays was 95.2%. For patients diagnosed with MI, cTnI reached higher peak concentrations in shorter time, compared to cTnT. All-cause mortality risk increased with increasing levels of both biomarkers. In this study, the analytical agreement of two cTn assays was high. However, some disparities in troponin trajectories were observed.

KW - acute coronary syndrome

KW - coronary artery disease

KW - diagnosis

KW - high-sensitivity troponin

KW - Myocardial infarction

KW - prognosis

UR - http://www.scopus.com/inward/record.url?scp=85126109638&partnerID=8YFLogxK

U2 - 10.1080/00365513.2022.2033310

DO - 10.1080/00365513.2022.2033310

M3 - Journal article

C2 - 35253566

AN - SCOPUS:85126109638

VL - 82

SP - 96

EP - 103

JO - Scandinavian Journal of Clinical and Laboratory Investigation. Supplement

JF - Scandinavian Journal of Clinical and Laboratory Investigation. Supplement

SN - 0085-591X

IS - 2

ER -