High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer

Emilia Wiechec; Carsten Wiuf; Jens Overgaard; Lise Lotte Hansen

doi:10.1158/1055-9965.EPI-10-0514

High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer

Emilia Wiechec, Carsten Wiuf, Jens Overgaard, Lise Lotte Hansen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

13 Citations (Scopus)

Abstract

Identification of specific mutation targets in cancer may lead to discovery of the genes modulating cancer susceptibility and/or prognosis. The RGSL1, RGS16, and RGS8 genes within the 1q25.3 region belong to the novel family of regulators of G protein signaling (RGS) genes, which increase the GTPase activity of the Gα subunit to attenuate signaling from the G protein-coupled receptor. We evaluated the use of high-resolution melting (HRM) to screen for mutations in the genes of interest and assess their clinical significance.

Original language	English
Journal	Cancer Epidemiology, Biomarkers & Prevention
Volume	20
Issue	2
Pages (from-to)	397-407
Number of pages	11
ISSN	1055-9965
DOIs	https://doi.org/10.1158/1055-9965.EPI-10-0514
Publication status	Published - 1 Mar 2011

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title = "High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer",

abstract = "Identification of specific mutation targets in cancer may lead to discovery of the genes modulating cancer susceptibility and/or prognosis. The RGSL1, RGS16, and RGS8 genes within the 1q25.3 region belong to the novel family of regulators of G protein signaling (RGS) genes, which increase the GTPase activity of the Gα subunit to attenuate signaling from the G protein-coupled receptor. We evaluated the use of high-resolution melting (HRM) to screen for mutations in the genes of interest and assess their clinical significance.",

author = "Emilia Wiechec and Carsten Wiuf and Jens Overgaard and Hansen, {Lise Lotte}",

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doi = "10.1158/1055-9965.EPI-10-0514",

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High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer. / Wiechec, Emilia; Wiuf, Carsten; Overgaard, Jens et al.
In: Cancer Epidemiology, Biomarkers & Prevention, Vol. 20, No. 2, 01.03.2011, p. 397-407.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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AU - Hansen, Lise Lotte

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N2 - Identification of specific mutation targets in cancer may lead to discovery of the genes modulating cancer susceptibility and/or prognosis. The RGSL1, RGS16, and RGS8 genes within the 1q25.3 region belong to the novel family of regulators of G protein signaling (RGS) genes, which increase the GTPase activity of the Gα subunit to attenuate signaling from the G protein-coupled receptor. We evaluated the use of high-resolution melting (HRM) to screen for mutations in the genes of interest and assess their clinical significance.

AB - Identification of specific mutation targets in cancer may lead to discovery of the genes modulating cancer susceptibility and/or prognosis. The RGSL1, RGS16, and RGS8 genes within the 1q25.3 region belong to the novel family of regulators of G protein signaling (RGS) genes, which increase the GTPase activity of the Gα subunit to attenuate signaling from the G protein-coupled receptor. We evaluated the use of high-resolution melting (HRM) to screen for mutations in the genes of interest and assess their clinical significance.

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DO - 10.1158/1055-9965.EPI-10-0514

M3 - Journal article

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VL - 20

SP - 397

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JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

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High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer

Abstract

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