High-dose folic acid and cancer risk; unjustified concerns by von Wrede and colleagues regarding our paper

Marte Helene Bjørk*, Torbjörn Tomson, Julie Werenberg Dreier, Silje Alvestad, Nils Erik Gilhus, Mika Gissler, Jannicke Igland, Maarit K. Leinonen, Yuelian Sun, Håkon Magne Vegrim, Helga Zoega, Jakob Christensen

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperComment/debate/letter to the editorResearchpeer-review

Abstract

Women using antiseizure medication in pregnancy are often advised to use high doses of folic acid supplements (1mg to 5 mg) to reduce the risk of teratogenicity. Recently, we published a report showing an association between maternal prescription fill of high dose folic acid in relation to pregnancy and childhood cancer in the offspring. The report has sparked a debate about which dose of folic acid that should be recommended in pregnancy in women in need of antiseizure medication. In this Commentary, we explain our findings and the method used in our report, and answer recent questions that have emerged.

Original languageEnglish
JournalEpilepsia
Volume64
Issue9
Pages (from-to)2244-2248
Number of pages5
ISSN0013-9580
DOIs
Publication statusPublished - Sept 2023

Keywords

  • anticonvulsant drugs
  • antiepileptic drug
  • B vitamins
  • childhood cancer
  • epilepsy
  • folate
  • pregnancy
  • Humans
  • Risk
  • Dietary Supplements/adverse effects
  • Pregnancy
  • Folic Acid/adverse effects
  • Female
  • Family
  • Child
  • Neoplasms/chemically induced

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