High burden of coronary atherosclerosis in patients with cirrhosis

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Standard

High burden of coronary atherosclerosis in patients with cirrhosis. / Kazankov, Konstantin; Munk, Kim; Øvrehus, Kristian Altern; Jensen, Jesper Møller; Siggaard, Cecilie Brøckner; Grønbaek, Henning; Nørgaard, Bjarne Linde; Vilstrup, Hendrik.

In: European Journal of Clinical Investigation, Vol. 47, No. 8, 08.2017, p. 565-573.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Kazankov, K, Munk, K, Øvrehus, KA, Jensen, JM, Siggaard, CB, Grønbaek, H, Nørgaard, BL & Vilstrup, H 2017, 'High burden of coronary atherosclerosis in patients with cirrhosis', European Journal of Clinical Investigation, vol. 47, no. 8, pp. 565-573. https://doi.org/10.1111/eci.12777

APA

Kazankov, K., Munk, K., Øvrehus, K. A., Jensen, J. M., Siggaard, C. B., Grønbaek, H., Nørgaard, B. L., & Vilstrup, H. (2017). High burden of coronary atherosclerosis in patients with cirrhosis. European Journal of Clinical Investigation, 47(8), 565-573. https://doi.org/10.1111/eci.12777

CBE

Kazankov K, Munk K, Øvrehus KA, Jensen JM, Siggaard CB, Grønbaek H, Nørgaard BL, Vilstrup H. 2017. High burden of coronary atherosclerosis in patients with cirrhosis. European Journal of Clinical Investigation. 47(8):565-573. https://doi.org/10.1111/eci.12777

MLA

Vancouver

Kazankov K, Munk K, Øvrehus KA, Jensen JM, Siggaard CB, Grønbaek H et al. High burden of coronary atherosclerosis in patients with cirrhosis. European Journal of Clinical Investigation. 2017 Aug;47(8):565-573. https://doi.org/10.1111/eci.12777

Author

Kazankov, Konstantin ; Munk, Kim ; Øvrehus, Kristian Altern ; Jensen, Jesper Møller ; Siggaard, Cecilie Brøckner ; Grønbaek, Henning ; Nørgaard, Bjarne Linde ; Vilstrup, Hendrik. / High burden of coronary atherosclerosis in patients with cirrhosis. In: European Journal of Clinical Investigation. 2017 ; Vol. 47, No. 8. pp. 565-573.

Bibtex

@article{2f729ae639214957a833cbd696db3a00,
title = "High burden of coronary atherosclerosis in patients with cirrhosis",
abstract = "BACKGROUND: Population studies report increased cardiovascular mortality in patients with cirrhosis. Coronary artery disease may be a trait of end-stage liver disease, but whether it is frequent or extensive in cirrhosis in general is unknown. Thus, we aimed to assess the prevalence and extent of coronary artery disease in unselected cirrhosis patients.MATERIALS AND METHODS: Using coronary computed tomography angiography, we investigated 52 patients from all Child-Pugh classes and aetiologies of cirrhosis without known cardiac disease for presence and severity of coronary artery disease in a cross-sectional design. Persons referred with new-onset chest pain served as controls.RESULTS: The prevalence of coronary artery disease was not significantly different between cirrhosis patients and controls (77% vs. 65%, P=0·19). However, cirrhosis patients had a markedly higher coronary artery calcification (Agatston) score than controls (120 [interquartile range, 0-345] vs. 5 [interquartile range, 0-86] HU, P=0·001). Likewise, patients with cirrhosis had a higher prevalence of extensive (≥5 coronary segments involved; 45% vs. 18%, P=0·01) and multivessel coronary disease (≥2 vessels involved; 75% vs. 53%, P=0·02). Furthermore, the total plaque volume whether noncalcified or calcified was higher in cirrhosis (117 [interquartile range, 0-310] vs. 36 [interquartile range, 0-148] mm(3) , P=0·02).CONCLUSION: Coronary artery disease is equally prevalent in patients with cirrhosis and subjects with new-onset chest pain, but cirrhosis patients have more extensive and severe disease including several coronary high-risk features associated with myocardial ischaemia and a poor clinical outcome. The potential of preventive measures for coronary artery disease in cirrhosis needs attention.",
keywords = "Journal Article",
author = "Konstantin Kazankov and Kim Munk and {\O}vrehus, {Kristian Altern} and Jensen, {Jesper M{\o}ller} and Siggaard, {Cecilie Br{\o}ckner} and Henning Gr{\o}nbaek and N{\o}rgaard, {Bjarne Linde} and Hendrik Vilstrup",
note = "{\textcopyright} 2017 Stichting European Society for Clinical Investigation Journal Foundation.",
year = "2017",
month = aug,
doi = "10.1111/eci.12777",
language = "English",
volume = "47",
pages = "565--573",
journal = "European Journal of Clinical Investigation",
issn = "0014-2972",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "8",

}

RIS

TY - JOUR

T1 - High burden of coronary atherosclerosis in patients with cirrhosis

AU - Kazankov, Konstantin

AU - Munk, Kim

AU - Øvrehus, Kristian Altern

AU - Jensen, Jesper Møller

AU - Siggaard, Cecilie Brøckner

AU - Grønbaek, Henning

AU - Nørgaard, Bjarne Linde

AU - Vilstrup, Hendrik

N1 - © 2017 Stichting European Society for Clinical Investigation Journal Foundation.

PY - 2017/8

Y1 - 2017/8

N2 - BACKGROUND: Population studies report increased cardiovascular mortality in patients with cirrhosis. Coronary artery disease may be a trait of end-stage liver disease, but whether it is frequent or extensive in cirrhosis in general is unknown. Thus, we aimed to assess the prevalence and extent of coronary artery disease in unselected cirrhosis patients.MATERIALS AND METHODS: Using coronary computed tomography angiography, we investigated 52 patients from all Child-Pugh classes and aetiologies of cirrhosis without known cardiac disease for presence and severity of coronary artery disease in a cross-sectional design. Persons referred with new-onset chest pain served as controls.RESULTS: The prevalence of coronary artery disease was not significantly different between cirrhosis patients and controls (77% vs. 65%, P=0·19). However, cirrhosis patients had a markedly higher coronary artery calcification (Agatston) score than controls (120 [interquartile range, 0-345] vs. 5 [interquartile range, 0-86] HU, P=0·001). Likewise, patients with cirrhosis had a higher prevalence of extensive (≥5 coronary segments involved; 45% vs. 18%, P=0·01) and multivessel coronary disease (≥2 vessels involved; 75% vs. 53%, P=0·02). Furthermore, the total plaque volume whether noncalcified or calcified was higher in cirrhosis (117 [interquartile range, 0-310] vs. 36 [interquartile range, 0-148] mm(3) , P=0·02).CONCLUSION: Coronary artery disease is equally prevalent in patients with cirrhosis and subjects with new-onset chest pain, but cirrhosis patients have more extensive and severe disease including several coronary high-risk features associated with myocardial ischaemia and a poor clinical outcome. The potential of preventive measures for coronary artery disease in cirrhosis needs attention.

AB - BACKGROUND: Population studies report increased cardiovascular mortality in patients with cirrhosis. Coronary artery disease may be a trait of end-stage liver disease, but whether it is frequent or extensive in cirrhosis in general is unknown. Thus, we aimed to assess the prevalence and extent of coronary artery disease in unselected cirrhosis patients.MATERIALS AND METHODS: Using coronary computed tomography angiography, we investigated 52 patients from all Child-Pugh classes and aetiologies of cirrhosis without known cardiac disease for presence and severity of coronary artery disease in a cross-sectional design. Persons referred with new-onset chest pain served as controls.RESULTS: The prevalence of coronary artery disease was not significantly different between cirrhosis patients and controls (77% vs. 65%, P=0·19). However, cirrhosis patients had a markedly higher coronary artery calcification (Agatston) score than controls (120 [interquartile range, 0-345] vs. 5 [interquartile range, 0-86] HU, P=0·001). Likewise, patients with cirrhosis had a higher prevalence of extensive (≥5 coronary segments involved; 45% vs. 18%, P=0·01) and multivessel coronary disease (≥2 vessels involved; 75% vs. 53%, P=0·02). Furthermore, the total plaque volume whether noncalcified or calcified was higher in cirrhosis (117 [interquartile range, 0-310] vs. 36 [interquartile range, 0-148] mm(3) , P=0·02).CONCLUSION: Coronary artery disease is equally prevalent in patients with cirrhosis and subjects with new-onset chest pain, but cirrhosis patients have more extensive and severe disease including several coronary high-risk features associated with myocardial ischaemia and a poor clinical outcome. The potential of preventive measures for coronary artery disease in cirrhosis needs attention.

KW - Journal Article

U2 - 10.1111/eci.12777

DO - 10.1111/eci.12777

M3 - Journal article

C2 - 28657113

VL - 47

SP - 565

EP - 573

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

SN - 0014-2972

IS - 8

ER -