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Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging

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  • Christian Thaler, University Medical Center Hamburg-Eppendorf
  • ,
  • Anna A Kyselyova, University Medical Center Hamburg-Eppendorf
  • ,
  • Tobias D Faizy, University Medical Center Hamburg-Eppendorf
  • ,
  • Marie T Nawka, University Medical Center Hamburg-Eppendorf
  • ,
  • Sune Jespersen
  • Brian Hansen
  • Jan-Patrick Stellmann, University Medical Center Hamburg-Eppendorf, La Timone Hospital University, Marseille, France.
  • ,
  • Christoph Heesen, University Medical Center Hamburg-Eppendorf
  • ,
  • Klarissa H Stürner, University Medical Center Hamburg-Eppendorf, University Hospital Schleswig-Holstein
  • ,
  • Maria Stark, University Medical Center Hamburg-Eppendorf
  • ,
  • Jens Fiehler, University Medical Center Hamburg-Eppendorf
  • ,
  • Maxim Bester, University Medical Center Hamburg-Eppendorf
  • ,
  • Susanne Gellißen, University Medical Center Hamburg-Eppendorf

BACKGROUND: Mean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders.

METHODS: Thirty-seven patients with relapsing-remitting MS and eleven healthy controls (HC) received brain imaging on a 3T MR scanner, including a fast DKI sequence. MK and mean diffusivity (MD) were measured in the white matter of HC, normal-appearing white matter (NAWM) of MS patients, contrast-enhancing lesions (CE-L), FLAIR lesions (FLAIR-L) and black holes (BH).

RESULTS: Overall 1529 lesions were analyzed, including 30 CE-L, 832 FLAIR-L and 667 BH. Highest MK values were obtained in the white matter of HC (0.814 ± 0.129), followed by NAWM (0.724 ± 0.137), CE-L (0.619 ± 0.096), FLAIR-L (0.565 ± 0.123) and BH (0.549 ± 0.12). Lowest MD values were obtained in the white matter of HC (0.747 ± 0.068 10-3mm2/sec), followed by NAWM (0.808 ± 0.163 10-3mm2/sec), CE-L (0.853 ± 0.211 10-3mm2/sec), BH (0.957 ± 0.304 10-3mm2/sec) and FLAIR-L (0.976 ± 0.35 10-3mm2/sec). While MK differed significantly between CE-L and non-enhancing lesions, MD did not.

CONCLUSION: MK adds predictive value to differentiate between MS lesions and might provide further information about diffuse white matter injury and lesion microstructure.

Original languageEnglish
Article numbere0245844
JournalPLOS ONE
Volume16
Issue2
Number of pages16
ISSN1932-6203
DOIs
Publication statusPublished - Feb 2021

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