Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study

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Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries : A Multinational Cohort Study. / Murphy, Neil; Ward, Heather A; Jenab, Mazda; Rothwell, Joseph A; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Kvaskoff, Marina; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Aleksandrova, Krasimira; Weiderpass, Elisabete; Skeie, Guri; Borch, Kristin Benjaminsen; Tjønneland, Anne; Kyrø, Cecilie; Overvad, Kim; Dahm, Christina C; Jakszyn, Paula; Sánchez, Maria-Jose; Gil, Leire; Huerta, José M; Barricarte, Aurelio; Quirós, J Ramón; Khaw, Kay-Tee; Wareham, Nick; Bradbury, Kathryn E; Trichopoulou, Antonia; La Vecchia, Carlo; Karakatsani, Anna; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Fasanelli, Francesca; Panico, Salvatore; Bueno-de-Mesquita, Bas; Peeters, Petra H; Gylling, Björn; Myte, Robin; Jirström, Karin; Berntsson, Jonna; Xue, Xiaonan; Riboli, Elio; Cross, Amanda J; Gunter, Marc J.

In: Clinical Gastroenterology and Hepatology, Vol. 17, No. 7, 06.2019, p. 1323-1331.e6.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Murphy, N, Ward, HA, Jenab, M, Rothwell, JA, Boutron-Ruault, M-C, Carbonnel, F, Kvaskoff, M, Kaaks, R, Kühn, T, Boeing, H, Aleksandrova, K, Weiderpass, E, Skeie, G, Borch, KB, Tjønneland, A, Kyrø, C, Overvad, K, Dahm, CC, Jakszyn, P, Sánchez, M-J, Gil, L, Huerta, JM, Barricarte, A, Quirós, JR, Khaw, K-T, Wareham, N, Bradbury, KE, Trichopoulou, A, La Vecchia, C, Karakatsani, A, Palli, D, Grioni, S, Tumino, R, Fasanelli, F, Panico, S, Bueno-de-Mesquita, B, Peeters, PH, Gylling, B, Myte, R, Jirström, K, Berntsson, J, Xue, X, Riboli, E, Cross, AJ & Gunter, MJ 2019, 'Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study', Clinical Gastroenterology and Hepatology, vol. 17, no. 7, pp. 1323-1331.e6. https://doi.org/10.1016/j.cgh.2018.07.030

APA

Murphy, N., Ward, H. A., Jenab, M., Rothwell, J. A., Boutron-Ruault, M-C., Carbonnel, F., Kvaskoff, M., Kaaks, R., Kühn, T., Boeing, H., Aleksandrova, K., Weiderpass, E., Skeie, G., Borch, K. B., Tjønneland, A., Kyrø, C., Overvad, K., Dahm, C. C., Jakszyn, P., ... Gunter, M. J. (2019). Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study. Clinical Gastroenterology and Hepatology, 17(7), 1323-1331.e6. https://doi.org/10.1016/j.cgh.2018.07.030

CBE

Murphy N, Ward HA, Jenab M, Rothwell JA, Boutron-Ruault M-C, Carbonnel F, Kvaskoff M, Kaaks R, Kühn T, Boeing H, Aleksandrova K, Weiderpass E, Skeie G, Borch KB, Tjønneland A, Kyrø C, Overvad K, Dahm CC, Jakszyn P, Sánchez M-J, Gil L, Huerta JM, Barricarte A, Quirós JR, Khaw K-T, Wareham N, Bradbury KE, Trichopoulou A, La Vecchia C, Karakatsani A, Palli D, Grioni S, Tumino R, Fasanelli F, Panico S, Bueno-de-Mesquita B, Peeters PH, Gylling B, Myte R, Jirström K, Berntsson J, Xue X, Riboli E, Cross AJ, Gunter MJ. 2019. Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study. Clinical Gastroenterology and Hepatology. 17(7):1323-1331.e6. https://doi.org/10.1016/j.cgh.2018.07.030

MLA

Vancouver

Murphy N, Ward HA, Jenab M, Rothwell JA, Boutron-Ruault M-C, Carbonnel F et al. Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study. Clinical Gastroenterology and Hepatology. 2019 Jun;17(7):1323-1331.e6. https://doi.org/10.1016/j.cgh.2018.07.030

Author

Murphy, Neil ; Ward, Heather A ; Jenab, Mazda ; Rothwell, Joseph A ; Boutron-Ruault, Marie-Christine ; Carbonnel, Franck ; Kvaskoff, Marina ; Kaaks, Rudolf ; Kühn, Tilman ; Boeing, Heiner ; Aleksandrova, Krasimira ; Weiderpass, Elisabete ; Skeie, Guri ; Borch, Kristin Benjaminsen ; Tjønneland, Anne ; Kyrø, Cecilie ; Overvad, Kim ; Dahm, Christina C ; Jakszyn, Paula ; Sánchez, Maria-Jose ; Gil, Leire ; Huerta, José M ; Barricarte, Aurelio ; Quirós, J Ramón ; Khaw, Kay-Tee ; Wareham, Nick ; Bradbury, Kathryn E ; Trichopoulou, Antonia ; La Vecchia, Carlo ; Karakatsani, Anna ; Palli, Domenico ; Grioni, Sara ; Tumino, Rosario ; Fasanelli, Francesca ; Panico, Salvatore ; Bueno-de-Mesquita, Bas ; Peeters, Petra H ; Gylling, Björn ; Myte, Robin ; Jirström, Karin ; Berntsson, Jonna ; Xue, Xiaonan ; Riboli, Elio ; Cross, Amanda J ; Gunter, Marc J. / Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries : A Multinational Cohort Study. In: Clinical Gastroenterology and Hepatology. 2019 ; Vol. 17, No. 7. pp. 1323-1331.e6.

Bibtex

@article{292b6beb3847456db224a109907b9b47,
title = "Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study",
abstract = "BACKGROUND AND AIMS: Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent results, possibly because most have been of insufficient size to identify heterogeneous associations with precision.METHODS: In the European Prospective Investigation into Cancer and Nutrition study, we used multivariable joint Cox proportional hazards models, which accounted for tumors at different anatomical sites (proximal colon, distal colon, and rectum) as competing risks, to examine the relationships between 14 established/suspected lifestyle, anthropometric, and reproductive/menstrual risk factors with colorectal cancer risk. Heterogeneity across sites was tested using Wald tests.RESULTS: After 14.9 years (median) follow-up of 521,330 men and women, 6,291 colorectal cancer cases occurred. Physical activity was inversely related to proximal colon and distal colon cancer, but not to rectal cancer (P-heterogeneity=0.03). Height was positively associated with proximal and distal colon cancer only, but not rectal cancer (P-heterogeneity=0.0001). For men, but not women, heterogeneous relationships were observed for body mass index (P-heterogeneity=0.008) and waist circumference (P-heterogeneity=0.03), with weaker positive associations found for rectal cancer, compared to proximal and distal colon cancer. Current smoking was associated with a greater risk of rectal and proximal colon cancer, but not distal colon cancer (P-heterogeneity=0.05). No heterogeneity by anatomical site was found for alcohol consumption, diabetes, nonsteroidal anti-inflammatory drug use, and reproductive/menstrual factors.CONCLUSIONS: The physical activity, anthropometry, and smoking relationships with colorectal cancer risk differed by subsite, supporting the hypothesis that tumors in different anatomical regions may have distinct etiologies.",
keywords = "colorectal cancer, anatomical subsite, distal colon, heterogeneity, proximal colon, rectum, risk factors",
author = "Neil Murphy and Ward, {Heather A} and Mazda Jenab and Rothwell, {Joseph A} and Marie-Christine Boutron-Ruault and Franck Carbonnel and Marina Kvaskoff and Rudolf Kaaks and Tilman K{\"u}hn and Heiner Boeing and Krasimira Aleksandrova and Elisabete Weiderpass and Guri Skeie and Borch, {Kristin Benjaminsen} and Anne Tj{\o}nneland and Cecilie Kyr{\o} and Kim Overvad and Dahm, {Christina C} and Paula Jakszyn and Maria-Jose S{\'a}nchez and Leire Gil and Huerta, {Jos{\'e} M} and Aurelio Barricarte and Quir{\'o}s, {J Ram{\'o}n} and Kay-Tee Khaw and Nick Wareham and Bradbury, {Kathryn E} and Antonia Trichopoulou and {La Vecchia}, Carlo and Anna Karakatsani and Domenico Palli and Sara Grioni and Rosario Tumino and Francesca Fasanelli and Salvatore Panico and Bas Bueno-de-Mesquita and Peeters, {Petra H} and Bj{\"o}rn Gylling and Robin Myte and Karin Jirstr{\"o}m and Jonna Berntsson and Xiaonan Xue and Elio Riboli and Cross, {Amanda J} and Gunter, {Marc J}",
note = "Copyright {\textcopyright} 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = jun,
doi = "10.1016/j.cgh.2018.07.030",
language = "English",
volume = "17",
pages = "1323--1331.e6",
journal = "Clinical Gastroenterology and Hepatology",
issn = "1542-3565",
publisher = "W.B. Saunders Co.",
number = "7",

}

RIS

TY - JOUR

T1 - Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries

T2 - A Multinational Cohort Study

AU - Murphy, Neil

AU - Ward, Heather A

AU - Jenab, Mazda

AU - Rothwell, Joseph A

AU - Boutron-Ruault, Marie-Christine

AU - Carbonnel, Franck

AU - Kvaskoff, Marina

AU - Kaaks, Rudolf

AU - Kühn, Tilman

AU - Boeing, Heiner

AU - Aleksandrova, Krasimira

AU - Weiderpass, Elisabete

AU - Skeie, Guri

AU - Borch, Kristin Benjaminsen

AU - Tjønneland, Anne

AU - Kyrø, Cecilie

AU - Overvad, Kim

AU - Dahm, Christina C

AU - Jakszyn, Paula

AU - Sánchez, Maria-Jose

AU - Gil, Leire

AU - Huerta, José M

AU - Barricarte, Aurelio

AU - Quirós, J Ramón

AU - Khaw, Kay-Tee

AU - Wareham, Nick

AU - Bradbury, Kathryn E

AU - Trichopoulou, Antonia

AU - La Vecchia, Carlo

AU - Karakatsani, Anna

AU - Palli, Domenico

AU - Grioni, Sara

AU - Tumino, Rosario

AU - Fasanelli, Francesca

AU - Panico, Salvatore

AU - Bueno-de-Mesquita, Bas

AU - Peeters, Petra H

AU - Gylling, Björn

AU - Myte, Robin

AU - Jirström, Karin

AU - Berntsson, Jonna

AU - Xue, Xiaonan

AU - Riboli, Elio

AU - Cross, Amanda J

AU - Gunter, Marc J

N1 - Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

PY - 2019/6

Y1 - 2019/6

N2 - BACKGROUND AND AIMS: Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent results, possibly because most have been of insufficient size to identify heterogeneous associations with precision.METHODS: In the European Prospective Investigation into Cancer and Nutrition study, we used multivariable joint Cox proportional hazards models, which accounted for tumors at different anatomical sites (proximal colon, distal colon, and rectum) as competing risks, to examine the relationships between 14 established/suspected lifestyle, anthropometric, and reproductive/menstrual risk factors with colorectal cancer risk. Heterogeneity across sites was tested using Wald tests.RESULTS: After 14.9 years (median) follow-up of 521,330 men and women, 6,291 colorectal cancer cases occurred. Physical activity was inversely related to proximal colon and distal colon cancer, but not to rectal cancer (P-heterogeneity=0.03). Height was positively associated with proximal and distal colon cancer only, but not rectal cancer (P-heterogeneity=0.0001). For men, but not women, heterogeneous relationships were observed for body mass index (P-heterogeneity=0.008) and waist circumference (P-heterogeneity=0.03), with weaker positive associations found for rectal cancer, compared to proximal and distal colon cancer. Current smoking was associated with a greater risk of rectal and proximal colon cancer, but not distal colon cancer (P-heterogeneity=0.05). No heterogeneity by anatomical site was found for alcohol consumption, diabetes, nonsteroidal anti-inflammatory drug use, and reproductive/menstrual factors.CONCLUSIONS: The physical activity, anthropometry, and smoking relationships with colorectal cancer risk differed by subsite, supporting the hypothesis that tumors in different anatomical regions may have distinct etiologies.

AB - BACKGROUND AND AIMS: Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that have examined this hypothesis have yielded inconsistent results, possibly because most have been of insufficient size to identify heterogeneous associations with precision.METHODS: In the European Prospective Investigation into Cancer and Nutrition study, we used multivariable joint Cox proportional hazards models, which accounted for tumors at different anatomical sites (proximal colon, distal colon, and rectum) as competing risks, to examine the relationships between 14 established/suspected lifestyle, anthropometric, and reproductive/menstrual risk factors with colorectal cancer risk. Heterogeneity across sites was tested using Wald tests.RESULTS: After 14.9 years (median) follow-up of 521,330 men and women, 6,291 colorectal cancer cases occurred. Physical activity was inversely related to proximal colon and distal colon cancer, but not to rectal cancer (P-heterogeneity=0.03). Height was positively associated with proximal and distal colon cancer only, but not rectal cancer (P-heterogeneity=0.0001). For men, but not women, heterogeneous relationships were observed for body mass index (P-heterogeneity=0.008) and waist circumference (P-heterogeneity=0.03), with weaker positive associations found for rectal cancer, compared to proximal and distal colon cancer. Current smoking was associated with a greater risk of rectal and proximal colon cancer, but not distal colon cancer (P-heterogeneity=0.05). No heterogeneity by anatomical site was found for alcohol consumption, diabetes, nonsteroidal anti-inflammatory drug use, and reproductive/menstrual factors.CONCLUSIONS: The physical activity, anthropometry, and smoking relationships with colorectal cancer risk differed by subsite, supporting the hypothesis that tumors in different anatomical regions may have distinct etiologies.

KW - colorectal cancer

KW - anatomical subsite

KW - distal colon

KW - heterogeneity

KW - proximal colon

KW - rectum

KW - risk factors

U2 - 10.1016/j.cgh.2018.07.030

DO - 10.1016/j.cgh.2018.07.030

M3 - Journal article

C2 - 30056182

VL - 17

SP - 1323-1331.e6

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

IS - 7

ER -