Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population

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Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population. / Nissen, J.; Trabjerg, Betina; Pedersen, M. G.; Banasik, Karina; Pedersen, Ole Birger; Sørensen, Erik; Nielsen, Kaspar René; Erikstrup, Christian; Petersen, Mikkel Steen; Paarup, Helene Martina; Bruun-Rasmussen, P.; Westergaard, D.; Hansen, T. F.; Pedersen, Carsten B.; Werge, Thomas; Torrey, Fuller; Hjalgrim, Henrik; Mortensen, Preben Bo; Yolken, Robert; Brunak, Søren; Ullum, Henrik; Burgdorf, K. S.

In: Psychoneuroendocrinology, Vol. 108, 01.10.2019, p. 150-154.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Nissen, J, Trabjerg, B, Pedersen, MG, Banasik, K, Pedersen, OB, Sørensen, E, Nielsen, KR, Erikstrup, C, Petersen, MS, Paarup, HM, Bruun-Rasmussen, P, Westergaard, D, Hansen, TF, Pedersen, CB, Werge, T, Torrey, F, Hjalgrim, H, Mortensen, PB, Yolken, R, Brunak, S, Ullum, H & Burgdorf, KS 2019, 'Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population', Psychoneuroendocrinology, vol. 108, pp. 150-154. https://doi.org/10.1016/j.psyneuen.2019.06.015, https://doi.org/10.1016/j.psyneuen.2019.06.015

APA

CBE

Nissen J, Trabjerg B, Pedersen MG, Banasik K, Pedersen OB, Sørensen E, Nielsen KR, Erikstrup C, Petersen MS, Paarup HM, Bruun-Rasmussen P, Westergaard D, Hansen TF, Pedersen CB, Werge T, Torrey F, Hjalgrim H, Mortensen PB, Yolken R, Brunak S, Ullum H, Burgdorf KS. 2019. Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population. Psychoneuroendocrinology. 108:150-154. https://doi.org/10.1016/j.psyneuen.2019.06.015, https://doi.org/10.1016/j.psyneuen.2019.06.015

MLA

Vancouver

Author

Nissen, J. ; Trabjerg, Betina ; Pedersen, M. G. ; Banasik, Karina ; Pedersen, Ole Birger ; Sørensen, Erik ; Nielsen, Kaspar René ; Erikstrup, Christian ; Petersen, Mikkel Steen ; Paarup, Helene Martina ; Bruun-Rasmussen, P. ; Westergaard, D. ; Hansen, T. F. ; Pedersen, Carsten B. ; Werge, Thomas ; Torrey, Fuller ; Hjalgrim, Henrik ; Mortensen, Preben Bo ; Yolken, Robert ; Brunak, Søren ; Ullum, Henrik ; Burgdorf, K. S. / Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population. In: Psychoneuroendocrinology. 2019 ; Vol. 108. pp. 150-154.

Bibtex

@article{db9022d039a7471b91576a07ea248bb8,
title = "Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population",
abstract = "Increasing evidence shows that latent infections and inflammation is associated with cognitive and behavioral changes in humans. This case-control study investigates the association between Herpes Simplex Virus Type 1 (HSV-1) infection and C-reactive Protein (CRP) levels, and psychiatric disorders and suicidal behavior. Public health register data from 81,912 participants in the Danish Blood Donor Study, were reviewed to identify individuals registered with an ICD-10 code of any psychiatric diagnosis, or who had attempted or committed suicide. We found 1,504 psychiatric cases and 353 suicidal cases; for all cases, controls were frequency-matched by age and sex, resulting in 5,336 participants. Plasma samples were analyzed for IgG-class antibodies against HSV-1 and CRP. HSV-1 infection was associated with suicidal behavior (odds-ratio, 1.40; 95{\%} confidence interval [CI] 1.11–1.77). Accounting for temporality, HSV-1 infection was associated with having first psychiatric disorder after the date of blood collection (incidence rate ration, 1.44; 95{\%} CI, 1.05–1.95). No association between CRP and psychiatric disorders or suicidal behavior was found. The finding that HSV-1 was associated with suicidal behavior and first psychiatric disorder indicates that infection may play a role in the etiology and pathogenesis of suicidal behavior and development of psychiatric disorders.",
keywords = "C-reactive protein, Herpes Simplex Virus type 1, Infection, Inflammation, Psychiatric disorders, Suicide",
author = "J. Nissen and Betina Trabjerg and Pedersen, {M. G.} and Karina Banasik and Pedersen, {Ole Birger} and Erik S{\o}rensen and Nielsen, {Kaspar Ren{\'e}} and Christian Erikstrup and Petersen, {Mikkel Steen} and Paarup, {Helene Martina} and P. Bruun-Rasmussen and D. Westergaard and Hansen, {T. F.} and Pedersen, {Carsten B.} and Thomas Werge and Fuller Torrey and Henrik Hjalgrim and Mortensen, {Preben Bo} and Robert Yolken and S{\o}ren Brunak and Henrik Ullum and Burgdorf, {K. S.}",
note = "Copyright {\circledC} 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2019",
month = "6",
day = "28",
doi = "10.1016/j.psyneuen.2019.06.015",
language = "English",
volume = "108",
pages = "150--154",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population

AU - Nissen, J.

AU - Trabjerg, Betina

AU - Pedersen, M. G.

AU - Banasik, Karina

AU - Pedersen, Ole Birger

AU - Sørensen, Erik

AU - Nielsen, Kaspar René

AU - Erikstrup, Christian

AU - Petersen, Mikkel Steen

AU - Paarup, Helene Martina

AU - Bruun-Rasmussen, P.

AU - Westergaard, D.

AU - Hansen, T. F.

AU - Pedersen, Carsten B.

AU - Werge, Thomas

AU - Torrey, Fuller

AU - Hjalgrim, Henrik

AU - Mortensen, Preben Bo

AU - Yolken, Robert

AU - Brunak, Søren

AU - Ullum, Henrik

AU - Burgdorf, K. S.

N1 - Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2019/6/28

Y1 - 2019/6/28

N2 - Increasing evidence shows that latent infections and inflammation is associated with cognitive and behavioral changes in humans. This case-control study investigates the association between Herpes Simplex Virus Type 1 (HSV-1) infection and C-reactive Protein (CRP) levels, and psychiatric disorders and suicidal behavior. Public health register data from 81,912 participants in the Danish Blood Donor Study, were reviewed to identify individuals registered with an ICD-10 code of any psychiatric diagnosis, or who had attempted or committed suicide. We found 1,504 psychiatric cases and 353 suicidal cases; for all cases, controls were frequency-matched by age and sex, resulting in 5,336 participants. Plasma samples were analyzed for IgG-class antibodies against HSV-1 and CRP. HSV-1 infection was associated with suicidal behavior (odds-ratio, 1.40; 95% confidence interval [CI] 1.11–1.77). Accounting for temporality, HSV-1 infection was associated with having first psychiatric disorder after the date of blood collection (incidence rate ration, 1.44; 95% CI, 1.05–1.95). No association between CRP and psychiatric disorders or suicidal behavior was found. The finding that HSV-1 was associated with suicidal behavior and first psychiatric disorder indicates that infection may play a role in the etiology and pathogenesis of suicidal behavior and development of psychiatric disorders.

AB - Increasing evidence shows that latent infections and inflammation is associated with cognitive and behavioral changes in humans. This case-control study investigates the association between Herpes Simplex Virus Type 1 (HSV-1) infection and C-reactive Protein (CRP) levels, and psychiatric disorders and suicidal behavior. Public health register data from 81,912 participants in the Danish Blood Donor Study, were reviewed to identify individuals registered with an ICD-10 code of any psychiatric diagnosis, or who had attempted or committed suicide. We found 1,504 psychiatric cases and 353 suicidal cases; for all cases, controls were frequency-matched by age and sex, resulting in 5,336 participants. Plasma samples were analyzed for IgG-class antibodies against HSV-1 and CRP. HSV-1 infection was associated with suicidal behavior (odds-ratio, 1.40; 95% confidence interval [CI] 1.11–1.77). Accounting for temporality, HSV-1 infection was associated with having first psychiatric disorder after the date of blood collection (incidence rate ration, 1.44; 95% CI, 1.05–1.95). No association between CRP and psychiatric disorders or suicidal behavior was found. The finding that HSV-1 was associated with suicidal behavior and first psychiatric disorder indicates that infection may play a role in the etiology and pathogenesis of suicidal behavior and development of psychiatric disorders.

KW - C-reactive protein

KW - Herpes Simplex Virus type 1

KW - Infection

KW - Inflammation

KW - Psychiatric disorders

KW - Suicide

UR - http://www.scopus.com/inward/record.url?scp=85068363073&partnerID=8YFLogxK

U2 - 10.1016/j.psyneuen.2019.06.015

DO - 10.1016/j.psyneuen.2019.06.015

M3 - Journal article

VL - 108

SP - 150

EP - 154

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -