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Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population

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  • J. Nissen, Københavns Universitet, Rigshospitalet
  • ,
  • Betina Trabjerg
  • M. G. Pedersen
  • Karina Banasik, Københavns Universitet
  • ,
  • Ole Birger Pedersen, Næstved Sygehus
  • ,
  • Erik Sørensen, Rigshospitalet
  • ,
  • Kaspar René Nielsen, Aalborg University
  • ,
  • Christian Erikstrup
  • Mikkel Steen Petersen
  • Helene Martina Paarup, Odense Universitetshospital
  • ,
  • P. Bruun-Rasmussen, Københavns Universitet
  • ,
  • D. Westergaard, Københavns Universitet
  • ,
  • T. F. Hansen, Københavns Universitet, Danish Headache Centre, Rigshospitalet, Institute of Biological Psychiatry, Copenhagen University Hospital, Copenhagen
  • ,
  • Carsten B. Pedersen
  • Thomas Werge, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen University Hospital, Copenhagen
  • ,
  • Fuller Torrey, MD School of Medicine
  • ,
  • Henrik Hjalgrim, Statens Serum Institut, Rigshospitalet
  • ,
  • Preben Bo Mortensen
  • Robert Yolken, Johns Hopkins University Hospital
  • ,
  • Søren Brunak, Københavns Universitet
  • ,
  • Henrik Ullum, Rigshospitalet
  • ,
  • K. S. Burgdorf, Rigshospitalet

Increasing evidence shows that latent infections and inflammation is associated with cognitive and behavioral changes in humans. This case-control study investigates the association between Herpes Simplex Virus Type 1 (HSV-1) infection and C-reactive Protein (CRP) levels, and psychiatric disorders and suicidal behavior. Public health register data from 81,912 participants in the Danish Blood Donor Study, were reviewed to identify individuals registered with an ICD-10 code of any psychiatric diagnosis, or who had attempted or committed suicide. We found 1,504 psychiatric cases and 353 suicidal cases; for all cases, controls were frequency-matched by age and sex, resulting in 5,336 participants. Plasma samples were analyzed for IgG-class antibodies against HSV-1 and CRP. HSV-1 infection was associated with suicidal behavior (odds-ratio, 1.40; 95% confidence interval [CI] 1.11–1.77). Accounting for temporality, HSV-1 infection was associated with having first psychiatric disorder after the date of blood collection (incidence rate ration, 1.44; 95% CI, 1.05–1.95). No association between CRP and psychiatric disorders or suicidal behavior was found. The finding that HSV-1 was associated with suicidal behavior and first psychiatric disorder indicates that infection may play a role in the etiology and pathogenesis of suicidal behavior and development of psychiatric disorders.

Original languageEnglish
JournalPsychoneuroendocrinology
Volume108
Pages (from-to)150-154
Number of pages5
ISSN0306-4530
DOIs
Publication statusPublished - 2019

    Research areas

  • C-reactive protein, Herpes Simplex Virus type 1, Infection, Inflammation, Psychiatric disorders, Suicide

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