Heritability of cough across two generations: the RHINESSA study

Össur Ingi Emilsson; Henrik Johansson; Ane Johannessen; Christer Janson; Andreas Palm; Karl A Franklin; Anna Oudin; Francisco Gómez Real; Mathias Holm; Thorarinn Gislason; Eva Lindberg; Rain Jõgi; Vivi Schlünssen; Francisco Javier Callejas-González; Jingwen Zhang; Andrei Malinovschi; Cecilie Svanes; Magnus Ekström

doi:10.1183/23120541.00071-2024

Heritability of cough across two generations: the RHINESSA study

Össur Ingi Emilsson^*, Henrik Johansson, Ane Johannessen, Christer Janson, Andreas Palm, Karl A Franklin, Anna Oudin, Francisco Gómez Real, Mathias Holm, Thorarinn Gislason, Eva Lindberg, Rain Jõgi, Vivi Schlünssen, Francisco Javier Callejas-González, Jingwen Zhang, Andrei Malinovschi, Cecilie Svanes, Magnus Ekström

^*Corresponding author for this work

Department of Public Health - Institute of Environmental and Occupational Medicine

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2 Citations (Scopus)

Abstract

AIM: Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive).

METHODS: The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30-54) answering detailed questionnaires in 2000 and 2010, and 8176 offspring ≥20 years answering similar questionnaires in 2012-2019. Chronic cough was categorised as productive or nonproductive (dry) cough. Associations between parental and offspring cough were analysed using mixed-effects logistic regression, adjusting for offspring age, sex, body mass index, smoking history, education level, current asthma, rhinitis, nocturnal gastroesophageal reflux; parent sex and smoking history; centre and family.

RESULTS: Among parents with nonproductive cough, 11% of their offspring reported nonproductive cough, compared with 7% of offspring to parents without nonproductive cough, adjusted odds ratio (aOR) 1.59 (95% confidence interval 1.20-2.10). Among parents with productive cough, 14% of their offspring reported productive cough, compared with 11% of offspring to parents without productive cough, aOR 1.34 (1.07-1.67). No associations were found between parent productive cough-offspring nonproductive cough, nor between parent nonproductive cough-offspring productive cough.

CONCLUSIONS: Parents with chronic cough are more likely to have offspring with chronic cough independent of parental asthma, suggesting cough to be a separate heritable trait. The type of cough is important, as the nonproductive cough in parent associates only with nonproductive cough in offspring, and the same applied for productive cough.

Original language	English
Article number	00071-2024
Journal	ERJ Open Research
Volume	10
Issue	4
Number of pages	9
ISSN	2312-0541
DOIs	https://doi.org/10.1183/23120541.00071-2024
Publication status	Published - 5 Aug 2024

Access to Document

10.1183/23120541.00071-2024

Cite this

Emilsson, Ö. I., Johansson, H., Johannessen, A., Janson, C., Palm, A., Franklin, K. A., Oudin, A., Gómez Real, F., Holm, M., Gislason, T., Lindberg, E., Jõgi, R., Schlünssen, V., Callejas-González, F. J., Zhang, J., Malinovschi, A., Svanes, C., & Ekström, M. (2024). Heritability of cough across two generations: the RHINESSA study. ERJ Open Research, 10(4), Article 00071-2024. https://doi.org/10.1183/23120541.00071-2024

@article{27bd5f9ea7e9434b8c0d134046cb055b,

title = "Heritability of cough across two generations: the RHINESSA study",

abstract = "AIM: Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive).METHODS: The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30-54) answering detailed questionnaires in 2000 and 2010, and 8176 offspring ≥20 years answering similar questionnaires in 2012-2019. Chronic cough was categorised as productive or nonproductive (dry) cough. Associations between parental and offspring cough were analysed using mixed-effects logistic regression, adjusting for offspring age, sex, body mass index, smoking history, education level, current asthma, rhinitis, nocturnal gastroesophageal reflux; parent sex and smoking history; centre and family.RESULTS: Among parents with nonproductive cough, 11% of their offspring reported nonproductive cough, compared with 7% of offspring to parents without nonproductive cough, adjusted odds ratio (aOR) 1.59 (95% confidence interval 1.20-2.10). Among parents with productive cough, 14% of their offspring reported productive cough, compared with 11% of offspring to parents without productive cough, aOR 1.34 (1.07-1.67). No associations were found between parent productive cough-offspring nonproductive cough, nor between parent nonproductive cough-offspring productive cough.CONCLUSIONS: Parents with chronic cough are more likely to have offspring with chronic cough independent of parental asthma, suggesting cough to be a separate heritable trait. The type of cough is important, as the nonproductive cough in parent associates only with nonproductive cough in offspring, and the same applied for productive cough.",

author = "Emilsson, {{\"O}ssur Ingi} and Henrik Johansson and Ane Johannessen and Christer Janson and Andreas Palm and Franklin, {Karl A} and Anna Oudin and {G{\'o}mez Real}, Francisco and Mathias Holm and Thorarinn Gislason and Eva Lindberg and Rain J{\~o}gi and Vivi Schl{\"u}nssen and Callejas-Gonz{\'a}lez, {Francisco Javier} and Jingwen Zhang and Andrei Malinovschi and Cecilie Svanes and Magnus Ekstr{\"o}m",

note = "Copyright {\textcopyright}The authors 2024.",

year = "2024",

month = aug,

day = "5",

doi = "10.1183/23120541.00071-2024",

language = "English",

volume = "10",

journal = "ERJ Open Research",

issn = "2312-0541",

publisher = "ERS publications",

number = "4",

}

Emilsson, ÖI, Johansson, H, Johannessen, A, Janson, C, Palm, A, Franklin, KA, Oudin, A, Gómez Real, F, Holm, M, Gislason, T, Lindberg, E, Jõgi, R, Schlünssen, V, Callejas-González, FJ, Zhang, J, Malinovschi, A, Svanes, C & Ekström, M 2024, 'Heritability of cough across two generations: the RHINESSA study', ERJ Open Research, vol. 10, no. 4, 00071-2024. https://doi.org/10.1183/23120541.00071-2024

TY - JOUR

T1 - Heritability of cough across two generations

T2 - the RHINESSA study

AU - Emilsson, Össur Ingi

AU - Johansson, Henrik

AU - Johannessen, Ane

AU - Janson, Christer

AU - Palm, Andreas

AU - Franklin, Karl A

AU - Oudin, Anna

AU - Gómez Real, Francisco

AU - Holm, Mathias

AU - Gislason, Thorarinn

AU - Lindberg, Eva

AU - Jõgi, Rain

AU - Schlünssen, Vivi

AU - Callejas-González, Francisco Javier

AU - Zhang, Jingwen

AU - Malinovschi, Andrei

AU - Svanes, Cecilie

AU - Ekström, Magnus

PY - 2024/8/5

Y1 - 2024/8/5

N2 - AIM: Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive).METHODS: The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30-54) answering detailed questionnaires in 2000 and 2010, and 8176 offspring ≥20 years answering similar questionnaires in 2012-2019. Chronic cough was categorised as productive or nonproductive (dry) cough. Associations between parental and offspring cough were analysed using mixed-effects logistic regression, adjusting for offspring age, sex, body mass index, smoking history, education level, current asthma, rhinitis, nocturnal gastroesophageal reflux; parent sex and smoking history; centre and family.RESULTS: Among parents with nonproductive cough, 11% of their offspring reported nonproductive cough, compared with 7% of offspring to parents without nonproductive cough, adjusted odds ratio (aOR) 1.59 (95% confidence interval 1.20-2.10). Among parents with productive cough, 14% of their offspring reported productive cough, compared with 11% of offspring to parents without productive cough, aOR 1.34 (1.07-1.67). No associations were found between parent productive cough-offspring nonproductive cough, nor between parent nonproductive cough-offspring productive cough.CONCLUSIONS: Parents with chronic cough are more likely to have offspring with chronic cough independent of parental asthma, suggesting cough to be a separate heritable trait. The type of cough is important, as the nonproductive cough in parent associates only with nonproductive cough in offspring, and the same applied for productive cough.

AB - AIM: Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive).METHODS: The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30-54) answering detailed questionnaires in 2000 and 2010, and 8176 offspring ≥20 years answering similar questionnaires in 2012-2019. Chronic cough was categorised as productive or nonproductive (dry) cough. Associations between parental and offspring cough were analysed using mixed-effects logistic regression, adjusting for offspring age, sex, body mass index, smoking history, education level, current asthma, rhinitis, nocturnal gastroesophageal reflux; parent sex and smoking history; centre and family.RESULTS: Among parents with nonproductive cough, 11% of their offspring reported nonproductive cough, compared with 7% of offspring to parents without nonproductive cough, adjusted odds ratio (aOR) 1.59 (95% confidence interval 1.20-2.10). Among parents with productive cough, 14% of their offspring reported productive cough, compared with 11% of offspring to parents without productive cough, aOR 1.34 (1.07-1.67). No associations were found between parent productive cough-offspring nonproductive cough, nor between parent nonproductive cough-offspring productive cough.CONCLUSIONS: Parents with chronic cough are more likely to have offspring with chronic cough independent of parental asthma, suggesting cough to be a separate heritable trait. The type of cough is important, as the nonproductive cough in parent associates only with nonproductive cough in offspring, and the same applied for productive cough.

UR - http://www.scopus.com/inward/record.url?scp=85201670969&partnerID=8YFLogxK

U2 - 10.1183/23120541.00071-2024

DO - 10.1183/23120541.00071-2024

M3 - Journal article

C2 - 39104957

SN - 2312-0541

VL - 10

JO - ERJ Open Research

JF - ERJ Open Research

IS - 4

M1 - 00071-2024

ER -

Heritability of cough across two generations: the RHINESSA study

Abstract

Access to Document

Other files and links

Fingerprint

Cite this