Hebbian plasticity in vivo: relevance and induction

Niels Andersen; Nathalie Krauth; Sadegh Nabavi

doi:10.1016/j.conb.2017.06.001

Hebbian plasticity in vivo: relevance and induction

Niels Andersen, Nathalie Krauth, Sadegh Nabavi

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Abstract

Hebbian plasticity, as represented by long-term potentiation (LTP) and long-term depression (LTD) of synapses, has been the most influential hypothesis to account for encoding of memories. The evidence for the physiological relevance of LTP is indisputable. However, until recently the ways by which LTP physiologically is induced in its natural environment, the brain, was less clear. Nonetheless, current evidence points to neuromodulators as an indispensable element. The case for LTD in vivo is less certain. Even its relevance has been a matter of speculation and doubts. However, emerging evidence for a physiological role for LTD is promising, as the phenomenon has been observed at different brain regions. More needs to be done before LTD can claim an equal status alongside LTP.

Original language	English
Journal	Current Opinion in Neurobiology
Volume	45
Pages (from-to)	188-192
Number of pages	5
ISSN	0959-4388
DOIs	https://doi.org/10.1016/j.conb.2017.06.001
Publication status	Published - 1 Aug 2017

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title = "Hebbian plasticity in vivo: relevance and induction",

abstract = "Hebbian plasticity, as represented by long-term potentiation (LTP) and long-term depression (LTD) of synapses, has been the most influential hypothesis to account for encoding of memories. The evidence for the physiological relevance of LTP is indisputable. However, until recently the ways by which LTP physiologically is induced in its natural environment, the brain, was less clear. Nonetheless, current evidence points to neuromodulators as an indispensable element. The case for LTD in vivo is less certain. Even its relevance has been a matter of speculation and doubts. However, emerging evidence for a physiological role for LTD is promising, as the phenomenon has been observed at different brain regions. More needs to be done before LTD can claim an equal status alongside LTP.",

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AU - Andersen, Niels

AU - Krauth, Nathalie

AU - Nabavi, Sadegh

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N2 - Hebbian plasticity, as represented by long-term potentiation (LTP) and long-term depression (LTD) of synapses, has been the most influential hypothesis to account for encoding of memories. The evidence for the physiological relevance of LTP is indisputable. However, until recently the ways by which LTP physiologically is induced in its natural environment, the brain, was less clear. Nonetheless, current evidence points to neuromodulators as an indispensable element. The case for LTD in vivo is less certain. Even its relevance has been a matter of speculation and doubts. However, emerging evidence for a physiological role for LTD is promising, as the phenomenon has been observed at different brain regions. More needs to be done before LTD can claim an equal status alongside LTP.

AB - Hebbian plasticity, as represented by long-term potentiation (LTP) and long-term depression (LTD) of synapses, has been the most influential hypothesis to account for encoding of memories. The evidence for the physiological relevance of LTP is indisputable. However, until recently the ways by which LTP physiologically is induced in its natural environment, the brain, was less clear. Nonetheless, current evidence points to neuromodulators as an indispensable element. The case for LTD in vivo is less certain. Even its relevance has been a matter of speculation and doubts. However, emerging evidence for a physiological role for LTD is promising, as the phenomenon has been observed at different brain regions. More needs to be done before LTD can claim an equal status alongside LTP.

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JO - Current Opinion in Neurobiology

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ER -

Hebbian plasticity in vivo: relevance and induction

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