Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease

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Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease. / Hagell, Peter; Crabb, Lesley; Pogarell, Oliver; Schrag, Anette; Widner, Håkan; Brooks, David J.; Oertel, Wolfgang H.; Quinn, Niall P.; Lindvall, Olle.

In: Movement Disorders, Vol. 15, No. 2, 04.04.2000, p. 224-229.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Hagell, P, Crabb, L, Pogarell, O, Schrag, A, Widner, H, Brooks, DJ, Oertel, WH, Quinn, NP & Lindvall, O 2000, 'Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease', Movement Disorders, vol. 15, no. 2, pp. 224-229. https://doi.org/10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W

APA

Hagell, P., Crabb, L., Pogarell, O., Schrag, A., Widner, H., Brooks, D. J., Oertel, W. H., Quinn, N. P., & Lindvall, O. (2000). Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease. Movement Disorders, 15(2), 224-229. https://doi.org/10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W

CBE

Hagell P, Crabb L, Pogarell O, Schrag A, Widner H, Brooks DJ, Oertel WH, Quinn NP, Lindvall O. 2000. Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease. Movement Disorders. 15(2):224-229. https://doi.org/10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W

MLA

Vancouver

Author

Hagell, Peter ; Crabb, Lesley ; Pogarell, Oliver ; Schrag, Anette ; Widner, Håkan ; Brooks, David J. ; Oertel, Wolfgang H. ; Quinn, Niall P. ; Lindvall, Olle. / Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease. In: Movement Disorders. 2000 ; Vol. 15, No. 2. pp. 224-229.

Bibtex

@article{a3dbd7cf4db14acfbcbc42922e549cee,
title = "Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease",
abstract = "Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown longterm graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the 'off'-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.",
keywords = "Health-related quality of life, Nottingham health profile, Parkinson's disease, Transplantation",
author = "Peter Hagell and Lesley Crabb and Oliver Pogarell and Anette Schrag and H{\aa}kan Widner and Brooks, {David J.} and Oertel, {Wolfgang H.} and Quinn, {Niall P.} and Olle Lindvall",
year = "2000",
month = apr,
day = "4",
doi = "10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W",
language = "English",
volume = "15",
pages = "224--229",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "JohnWiley & Sons, Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease

AU - Hagell, Peter

AU - Crabb, Lesley

AU - Pogarell, Oliver

AU - Schrag, Anette

AU - Widner, Håkan

AU - Brooks, David J.

AU - Oertel, Wolfgang H.

AU - Quinn, Niall P.

AU - Lindvall, Olle

PY - 2000/4/4

Y1 - 2000/4/4

N2 - Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown longterm graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the 'off'-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.

AB - Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown longterm graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the 'off'-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.

KW - Health-related quality of life

KW - Nottingham health profile

KW - Parkinson's disease

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=0034073869&partnerID=8YFLogxK

U2 - 10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W

DO - 10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W

M3 - Journal article

C2 - 10752570

AN - SCOPUS:0034073869

VL - 15

SP - 224

EP - 229

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 2

ER -