Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease

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  • Peter Hagell, Lunds Universitet, Lund University Hospital
  • ,
  • Lesley Crabb, MRC Prion Unit, Institute of Neurology
  • ,
  • Oliver Pogarell, Philipps-Universität Marburg
  • ,
  • Anette Schrag, MRC Prion Unit, Institute of Neurology
  • ,
  • Håkan Widner, Lund University Hospital, Lunds Universitet
  • ,
  • David J. Brooks
  • Wolfgang H. Oertel, Philipps-Universität Marburg
  • ,
  • Niall P. Quinn, MRC Prion Unit, Institute of Neurology
  • ,
  • Olle Lindvall, Lunds Universitet, Lund University Hospital

Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown longterm graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the 'off'-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.

Original languageEnglish
JournalMovement Disorders
Volume15
Issue2
Pages (from-to)224-229
Number of pages6
ISSN0885-3185
DOIs
Publication statusPublished - 4 Apr 2000
Externally publishedYes

    Research areas

  • Health-related quality of life, Nottingham health profile, Parkinson's disease, Transplantation

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