TY - JOUR
T1 - Health-related quality of life is impaired in people with autoimmune hepatitis
T2 - Results of a multicentre cross-sectional study within the European Reference Network
AU - Snijders, Romée J A L M
AU - Janik, Maciej K
AU - Mund, Meike
AU - Uhlenbusch, Natalie
AU - Raszeja-Wyszomirska, Joanna
AU - Gerussi, Alessio
AU - Bolis, Francesca
AU - Cristoferi, Laura
AU - Invernizzi, Pietro
AU - Kovats, Patricia
AU - Papp, Mária
AU - Grønbæk, Lisbet
AU - Grønbæk, Henning
AU - Tjwa, Eric T T L
AU - Aamann, Luise
AU - Ytting, Henriette
AU - Ronca, Vincenzo
AU - Olsen, Kathryn
AU - Oo, Ye H
AU - van der Meer, Adriaan J
AU - Madaleno, João
AU - Canhão, Bernardo
AU - Engel, Bastian
AU - Campos-Murguia, Alejandro
AU - Taubert, Richard
AU - Koc, Özgür M
AU - Kramer, Matthijs
AU - Willemse, José A
AU - Löwe, Bernd
AU - Lohse, Ansgar W
AU - Drenth, Joost P H
AU - Schramm, Christoph
AU - Milkiewicz, Piotr
AU - Gevers, Tom J
N1 - Copyright © 2025 American Association for the Study of Liver Diseases.
PY - 2025/11
Y1 - 2025/11
N2 - Background and Aims: – Impaired health-related quality of life (HRQoL) contributes to the overall disease burden in autoimmune hepatitis (AIH). This study aimed to evaluate HRQoL in people with AIH and to identify potentially modifiable factors associated with impaired HRQoL using validated patient-reported outcome measures. Approach and Results: – Adult patients with AIH diagnosed at 12 European centers were enrolled in this prospective, cross-sectional study from July 2020 to June 2023. HRQoL was assessed using the Physical Component Score (PCS) and Mental Component Score (MCS) of the 12-item Short Form Health Survey (SF-12), and the European Quality-of-life 5-Dimension 5-Level (EQ-5D-5L) utility index score. Mixed-model regression analyses identified factors associated with HRQoL and somatic symptom severity. Controls were recruited from the general population in 5 European countries. A total of 882 patients with AIH (mean age: 51.0 y [SD: 17.0]; 76.4% female) and 178 controls were included. Physical but not mental HRQoL was impaired in the AIH group compared with the control group (PCS: 46.3 vs. 51.9, p<0.001; EQ-5D utility index score: 0.87 vs. 0.95, p<0.001). HRQoL was associated with severe somatic symptoms (PCS: β=−4.26, p<0.001), fatigue (PCS: β=−0.25, p<0.001; MCS: β=−0.25, p<0.001), and depression/anxiety (PCS: β=−3.37, p<0.001; MCS: β=−6.79, p<0.001). A complete biochemical response was associated with lower somatic symptom severity (OR: 0.69, p<0.05). Conclusions: – People with AIH had impaired HRQoL compared with controls, particularly in terms of physical well-being. HRQoL scores are associated with symptom burden, encompassing both somatic and psychosocial dimensions.
AB - Background and Aims: – Impaired health-related quality of life (HRQoL) contributes to the overall disease burden in autoimmune hepatitis (AIH). This study aimed to evaluate HRQoL in people with AIH and to identify potentially modifiable factors associated with impaired HRQoL using validated patient-reported outcome measures. Approach and Results: – Adult patients with AIH diagnosed at 12 European centers were enrolled in this prospective, cross-sectional study from July 2020 to June 2023. HRQoL was assessed using the Physical Component Score (PCS) and Mental Component Score (MCS) of the 12-item Short Form Health Survey (SF-12), and the European Quality-of-life 5-Dimension 5-Level (EQ-5D-5L) utility index score. Mixed-model regression analyses identified factors associated with HRQoL and somatic symptom severity. Controls were recruited from the general population in 5 European countries. A total of 882 patients with AIH (mean age: 51.0 y [SD: 17.0]; 76.4% female) and 178 controls were included. Physical but not mental HRQoL was impaired in the AIH group compared with the control group (PCS: 46.3 vs. 51.9, p<0.001; EQ-5D utility index score: 0.87 vs. 0.95, p<0.001). HRQoL was associated with severe somatic symptoms (PCS: β=−4.26, p<0.001), fatigue (PCS: β=−0.25, p<0.001; MCS: β=−0.25, p<0.001), and depression/anxiety (PCS: β=−3.37, p<0.001; MCS: β=−6.79, p<0.001). A complete biochemical response was associated with lower somatic symptom severity (OR: 0.69, p<0.05). Conclusions: – People with AIH had impaired HRQoL compared with controls, particularly in terms of physical well-being. HRQoL scores are associated with symptom burden, encompassing both somatic and psychosocial dimensions.
KW - anxiety
KW - autoimmune hepatitis
KW - complete biochemical response
KW - depression
KW - mental health
KW - physical health
KW - quality of life
KW - somatic symptom burden
KW - symptoms
UR - https://www.scopus.com/pages/publications/85218769201
U2 - 10.1097/HEP.0000000000001271
DO - 10.1097/HEP.0000000000001271
M3 - Journal article
C2 - 39970194
SN - 0270-9139
VL - 82
SP - 1058
EP - 1072
JO - Hepatology
JF - Hepatology
IS - 5
M1 - 10.1097/HEP.0000000000001271
ER -