Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)

Isabelle Thierry-Chef*, Beate Timmermann, Neige Journy, Marie Odile Bernier, Richard McNally, Jérémie Dabin, Lorenzo Brualla, Siamak Haghdoost, Adelaida Sarukhan, Karin Haustermans, Inge De Wit, Sofie Isebaert, Yasmin Lassen-Ramshad, Louise Tram Henriksen, Morten Høyer, Laura Toussaint, Guillaume Boissonnat, Juliette Thariat, Charlotte Demoor-Goldschmidt, Nadia HaddyStéphanie Bolle, Brice Fresneau, Amel Belhout, Steffen Dreger, Hajo Zeeb, Maria Grazia Andreassi, Jonica Campolo, Eugenio Picano, Andreas Jahnen, Cécile Ronckers, John H. Maduro, Kristina Kjaerheim, Gaute Døhlen, Trude Eid Robsahm, Hilde M. Olerud, Utheya Salini Thevathas, Susmita Afroz, Bjørn Helge à Sterås, Uwe Schneider, Linda Walsh, Agnès Dumas, Angéla Jackson, Estelle Rage, Marijke De Saint-Hubert, Richard Hardy, Christian Bäumer, Theresa Steinmeier, Suzan Botzenhardt, Martina Wette, Rodney Ortiz, Vadim Chumak

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) - radiation energy in MeV range - and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) - radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.

Original languageEnglish
Article number22
JournalEPJ Nuclear Sciences and Technologies
Volume9
Issue22
DOIs
Publication statusPublished - 2023

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